HitPredict

Interactor 1: AURKA (O14965)
Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A)
Gene: AURKA

Interactor 2: TTC4 (O95801)
Tetratricopeptide repeat protein 4 (TPR repeat protein 4)
Gene: TTC4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	26186194
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 403 Hs			1 387
+	Hs
		160553 AURKA_HUMAN (1-403): 2.51e-162: 463: 100.00		FKBP5_HUMAN (10-255): 2.21e-42: 155: 17.56
+	Hs
		682153 AKT2_HUMAN (27-401): 2.97e-142: 415: 25.00		TTC3_HUMAN (45-340): 1.67e-40: 155: 14.90
+	Hs
		682173 AKT2_HUMAN (27-401): 2.97e-142: 415: 25.00		FKBP5_HUMAN (10-255): 2.21e-42: 155: 17.56
+	Hs
		1035058 AKT3_HUMAN (29-401): 1.27e-140: 411: 23.76		FKBP5_HUMAN (10-255): 2.21e-42: 155: 17.56
+	Hs
		865097 AKT3_HUMAN (29-401): 1.27e-140: 411: 23.76		TTC3_HUMAN (45-340): 1.67e-40: 155: 14.90
+	Hs
		681754 AKT1_HUMAN (27-401): 3.06e-138: 404: 25.07		TTC3_HUMAN (45-340): 1.67e-40: 155: 14.90
+	Hs
		681830 AKT1_HUMAN (27-401): 3.06e-138: 404: 25.07		FKBP5_HUMAN (10-255): 2.21e-42: 155: 17.56
+	Rn
		858690 AKT3_RAT (29-401): 9.76e-139: 406: 23.76		PPP5_RAT (63-268): 7.3e-41: 152: 16.51
+	Mm
		103653 AKT1_MOUSE (27-401): 4.36e-139: 407: 24.81		G5E8T2_MOUSE (45-340): 4.61e-39: 150: 13.91
+	Hs
		969070 KPCE_HUMAN (4-401): 3.82e-137: 410: 24.33		FKBP4_HUMAN (39-247): 3.08e-37: 141: 16.36
+	Mm
		682131 AKT1_MOUSE (27-401): 4.36e-139: 407: 24.81		CHIP_MOUSE (55-365): 2.66e-39: 143: 15.24
+	Hs
		568651 KAPCA_HUMAN (117-400): 5.82e-136: 394: 29.76		FKBP5_HUMAN (10-255): 2.21e-42: 155: 17.56
+	Hs
		610723 KAPCB_HUMAN (117-400): 2.4e-135: 393: 30.80		FKBP5_HUMAN (10-255): 2.21e-42: 155: 17.56
+	Hs
		682070 AKT1_HUMAN (27-401): 3.06e-138: 404: 25.07		CHIP_HUMAN (74-365): 9.58e-39: 142: 15.88
+	Hs
		1034964 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		FKBP5_HUMAN (10-255): 2.21e-42: 155: 17.56
+	Hs
		568829 KAPCA_HUMAN (117-400): 5.82e-136: 394: 29.76		CHIP_HUMAN (74-365): 9.58e-39: 142: 15.88
+	Hs
		1035054 AURKC_HUMAN (115-389): 7.45e-130: 377: 68.73		FKBP5_HUMAN (10-255): 2.21e-42: 155: 17.56
+	Hs
		175113 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		OGT1_HUMAN (55-327): 5.32e-26: 112: 12.45
+	Rn
		193486 AKT3_RAT (29-401): 9.76e-139: 406: 23.76		STIP1_RAT (76-220): 5.41e-13: 72.2: 20.40
+	Hs
		684955 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		STIP1_HUMAN (76-220): 8.55e-13: 71.4: 19.74