HitPredict

Interactor 1: AURKA (O14965)
Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A)
Gene: AURKA

Interactor 2: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17851643
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 403 Hs			1 840
+	Hs
		681688 AKT1_HUMAN (27-401): 3.06e-138: 404: 25.07		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		568562 KAPCA_HUMAN (117-400): 5.82e-136: 394: 29.76		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		320896 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		HS74L_HUMAN (1-840): 0: 959: 63.21
+	Hs
		129031 PLK4_HUMAN (130-391): 1.82e-53: 192: 37.74		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		160349 AURKA_HUMAN (1-403): 2.51e-162: 463: 100.00		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		503922 KPCE_HUMAN (4-401): 3.82e-137: 410: 24.33		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		503528 AKT1_HUMAN (27-401): 3.06e-138: 404: 25.07		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Mm
		554912 KPCE_MOUSE (4-401): 1.29e-136: 409: 24.57		HS71A_MOUSE (571-686): 1e-17: 89.7: 23.08
+	Hs
		564016 AKT1_HUMAN (27-401): 3.06e-138: 404: 25.07		HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86