Protein: IRS2
Insulin receptor substrate 2 (IRS-2)

Gene: IRS2
Organism: Homo sapiens
Interactions: 71
UniProt ID: Q9Y4H2

Gene Ontology (top 5):
GO:0002053 - positive regulation of mesenchymal cell proliferation
GO:0002903 - negative regulation of B cell apoptotic process
GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005158 - insulin receptor binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

439887

INSR
Insulin receptor

3

20

Small-scale

0.854

High

988063

GRB2
Growth factor receptor-bound protein 2

2

20

Small-scale

0.777

High

699905

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

12

19

Small-scale

0.755

High

159933

DVL2
Segment polarity protein dishevelled homolog DVL-2

2

8

Small-scale

0.754

High

658798

JAK1
Tyrosine-protein kinase JAK1

2

20

Small-scale

0.754

High

920398

PLK1
Serine/threonine-protein kinase PLK1

2

9

High-throughput

0.754

High

1102388

GRB10
Growth factor receptor-bound protein 10

2

20

Small-scale

0.754

High

730394

1433B
14-3-3 protein beta/alpha

6

20

High-throughput

0.736

High

619141

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

2

2

Small-scale

0.727

High

691578

1433T
14-3-3 protein theta

5

20

High-throughput

0.718

High

990915

1433Z
14-3-3 protein zeta/delta

5

20

High-throughput

0.718

High

967067

1433G
14-3-3 protein gamma

5

20

High-throughput

0.718

High

1049946

1433F
14-3-3 protein eta

5

20

High-throughput

0.716

High

1364903

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

3

20

Small-scale

0.667

High

972174

1433E
14-3-3 protein epsilon

3

8

Small-scale

0.657

High

714667

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

20

Small-scale

0.647

High

1006824

SRPK2
SRSF protein kinase 2

1

12

High-throughput

0.647

High

1322683

RPTOR
Regulatory-associated protein of mTOR

1

12

Small-scale

0.647

High

1388782

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

9

Small-scale

0.641

High

193315

SOCS1
Suppressor of cytokine signaling 1

3

20

Small-scale

0.640

High

839115

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

3

7

Small-scale

0.633

High

168004

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

9

Small-scale

0.618

High

364079

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.618

High

412872

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

583038

EZRI
Ezrin

1

7

High-throughput

0.618

High

658627

KS6B1
Ribosomal protein S6 kinase beta-1

1

10

Small-scale

0.618

High

978426

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

1448424

SH2B1
SH2B adapter protein 1

1

20

Small-scale

0.618

High

1461020

FBW1B
F-box/WD repeat-containing protein 11

1

10

High-throughput

0.618

High

1462015

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.618

High

1490758

NISCH
Nischarin

1

6

Small-scale

0.618

High

730986

1433S
14-3-3 protein sigma

2

20

High-throughput

0.601

High

465699

IGF1R
Insulin-like growth factor 1 receptor

1

20

Small-scale

0.590

High

861856

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

9

Small-scale

0.578

High

766051

BMI1
Polycomb complex protein BMI-1

1

5

High-throughput

0.536

High

1435497

EGLN3
Prolyl hydroxylase EGLN3

1

5

High-throughput

0.536

High

1335228

NETO2
Neuropilin and tolloid-like protein 2

1

2

High-throughput

0.489

High

1386757

AP2M1
AP-2 complex subunit mu

1

0

High-throughput

0.480

High

155975

SOCS3
Suppressor of cytokine signaling 3

1

20

Small-scale

0.479

High

173605

XPO1
Exportin-1

1

4

High-throughput

0.479

High

208595

PJA2
E3 ubiquitin-protein ligase Praja-2

1

3

Small-scale

0.479

High

397311

ESR1
Estrogen receptor

1

20

Small-scale

0.479

High

404568

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

522146

BCL2
Apoptosis regulator Bcl-2

1

4

Small-scale

0.479

High

590123

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.479

High

619234

EPOR
Erythropoietin receptor

1

5

Small-scale

0.479

High

643159

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

5

High-throughput

0.479

High

696962

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

773099

MYH9
Myosin-9

1

2

High-throughput

0.479

High

839416

MTOR
Serine/threonine-protein kinase mTOR

1

3

Small-scale

0.479

High

896675

VASP
Vasodilator-stimulated phosphoprotein

1

2

High-throughput

0.479

High

968054

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

7

High-throughput

0.479

High

1053776

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

10

Small-scale

0.479

High

1110217

HDAC1
Histone deacetylase 1

1

12

High-throughput

0.479

High

1114744

CUL3
Cullin-3

1

16

High-throughput

0.479

High

1138812

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

1289746

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

1333383

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.479

High

1338452

FBX22
F-box only protein 22

1

2

High-throughput

0.479

High

1371578

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

10

Small-scale

0.479

High

1371801

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

11

Small-scale

0.479

High

1452439

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

4

High-throughput

0.479

High

1461514

BRPF3
Bromodomain and PHD finger-containing protein 3

1

7

High-throughput

0.479

High

1491396

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

5

Small-scale

0.479

High

1491409

EPN1
Epsin-1

1

5

Small-scale

0.479

High

174647

TRI66
Tripartite motif-containing protein 66

1

15

High-throughput

0.437

High

247054

KDM1A
Lysine-specific histone demethylase 1A

1

2

High-throughput

0.437

High

551355

PCNA
Proliferating cell nuclear antigen

1

2

High-throughput

0.437

High

604767

UBF1
Nucleolar transcription factor 1

1

12

Small-scale

0.437

High

1384491

PF21A
PHD finger protein 21A

1

14

High-throughput

0.437

High

1418338

RM01
Large ribosomal subunit protein uL1m

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025