HitPredict

Interactor 1: AURKA (O14965)
Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A)
Gene: AURKA

Interactor 2: Q9HCK3 (Q9HCK3)
KIAA1569 protein
Gene: KIAA1569

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.745

Property	Details
Experiments	24613305, 26186194, 28514442, 33961781, 32989298, 32707033, 36736316, 20360068, 23443559
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005814 - centriole GO:0019901 - protein kinase binding GO:0071539 - protein localization to centrosome
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 403 Hs			1 1140
+	Hs
		160678 AURKA_HUMAN (1-403): 2.51e-162: 463: 100.00		CE192_HUMAN (21-1140): 0: 2249: 99.82
+	Hs
		1292236 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		Q9HCK3_HUMAN (1-1140): 0: 2300: 100.00
+	Hs
		129054 PLK4_HUMAN (130-391): 1.82e-53: 192: 37.74		Q9HCK3_HUMAN (1-1140): 0: 2300: 100.00
+	Hs
		129030 PLK4_HUMAN (130-391): 1.82e-53: 192: 37.74		CE192_HUMAN (21-1140): 0: 2249: 99.82
+	Mm
		93523 PLK4_MOUSE (130-391): 2.11e-52: 189: 36.60		E9Q4Y4_MOUSE (21-1140): 0: 2136: 76.14