Protein: PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta) (Serine/threonine protein kinase PIK3CB) (EC 2.7.11.1)

Gene: PK3CB, PIK3CB
Organism: Homo sapiens
Interactions: 80
UniProt ID: P42338

Gene Ontology (top 5):
GO:0001935 - endothelial cell proliferation
GO:0001952 - regulation of cell-matrix adhesion
GO:0002931 - response to ischemia
GO:0003376 - sphingosine-1-phosphate receptor signaling pathway
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

655252

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

12

20

Small-scale

0.982

High

129231

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

8

20

Small-scale

0.973

High

787386

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

5

20

Small-scale

0.919

High

787365

GRB2
Growth factor receptor-bound protein 2

3

20

High-throughput

0.871

High

787357

CRK
Adapter molecule crk

3

18

High-throughput

0.817

High

787383

HAVR2
Hepatitis A virus cellular receptor 2

2

2

High-throughput

0.726

High

130291

BT3A1
Butyrophilin subfamily 3 member A1

1

3

High-throughput

0.691

High

787358

CRKL
Crk-like protein

1

16

High-throughput

0.691

High

739917

TGFR2
TGF-beta receptor type-2

3

1

High-throughput

0.667

High

787356

PE2R3
Prostaglandin E2 receptor EP3 subtype

3

9

High-throughput

0.667

High

787361

EFNB2
Ephrin-B2

3

4

High-throughput

0.667

High

787374

PCBP1
Poly(rC)-binding protein 1

3

2

High-throughput

0.667

High

452157

CD7
T-cell antigen CD7

1

0

High-throughput

0.656

High

610280

CBL
E3 ubiquitin-protein ligase CBL

3

6

Small-scale

0.656

High

787362

RAB5B
Ras-related protein Rab-5B

1

16

Small-scale

0.647

High

338075

EGFR
Epidermal growth factor receptor

3

20

Small-scale

0.640

High

591198

ACM3
Muscarinic acetylcholine receptor M3

2

9

High-throughput

0.628

High

702750

CADH5
Cadherin-5

2

2

High-throughput

0.628

High

787381

RN19B
E3 ubiquitin-protein ligase RNF19B

2

6

High-throughput

0.628

High

787385

RPGF5
Rap guanine nucleotide exchange factor 5

2

2

High-throughput

0.628

High

787393

DOCK5
Dedicator of cytokinesis protein 5

2

1

High-throughput

0.628

High

787399

NLGN3
Neuroligin-3

2

1

High-throughput

0.628

High

787400

FLRT1
Leucine-rich repeat transmembrane protein FLRT1

2

3

High-throughput

0.628

High

787404

I20RA
Interleukin-20 receptor subunit alpha

2

3

High-throughput

0.628

High

349947

RASK
GTPase KRas

1

20

High-throughput

0.618

High

592136

RAB5A
Ras-related protein Rab-5A

1

17

Small-scale

0.618

High

787364

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

3

Small-scale

0.618

High

787394

WDR26
WD repeat-containing protein 26

1

7

Small-scale

0.618

High

787403

SEPT9
Septin-9

2

1

High-throughput

0.601

High

724517

IRS1
Insulin receptor substrate 1

2

8

Small-scale

0.584

High

787378

TM52B
Transmembrane protein 52B

2

1

High-throughput

0.574

High

787384

ZDHC1
Palmitoyltransferase ZDHHC1

2

7

High-throughput

0.574

High

787396

MANS1
MANSC domain-containing protein 1

2

1

High-throughput

0.574

High

787402

CCG5
Voltage-dependent calcium channel gamma-5 subunit

2

2

High-throughput

0.574

High

626630

ARBK1
Beta-adrenergic receptor kinase 1

1

10

Small-scale

0.561

High

646704

1433T
14-3-3 protein theta

1

20

Small-scale

0.561

High

126573

P2Y10
Putative P2Y purinoceptor 10

1

20

High-throughput

0.536

High

151731

IRS4
Insulin receptor substrate 4

1

7

High-throughput

0.536

High

601832

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.536

High

787360

V1BR
Vasopressin V1b receptor

1

14

High-throughput

0.536

High

787363

CXCR4
C-X-C chemokine receptor type 4

1

13

High-throughput

0.536

High

787367

CAV1
Caveolin-1

1

1

High-throughput

0.536

High

787371

TP53B
TP53-binding protein 1

1

5

High-throughput

0.536

High

787376

AINX
Alpha-internexin

1

3

High-throughput

0.536

High

787380

KLD10
Kelch domain-containing protein 10

1

3

High-throughput

0.536

High

787389

TMM74
Transmembrane protein 74

1

2

High-throughput

0.536

High

787390

FEM1A
Protein fem-1 homolog A

1

4

High-throughput

0.536

High

787391

GTPB4
GTP-binding protein 4

1

1

High-throughput

0.536

High

787401

HCST
Hematopoietic cell signal transducer

1

1

High-throughput

0.536

High

787407

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

1

High-throughput

0.536

High

518832

TPR
Nucleoprotein TPR

1

10

High-throughput

0.515

High

394274

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.515

High

180011

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

0

High-throughput

0.513

High

548158

KCNE1
Potassium voltage-gated channel subfamily E member 1

1

0

High-throughput

0.513

High

787359

GLYG
Glycogenin-1

1

0

High-throughput

0.513

High

787375

SF3A2
Splicing factor 3A subunit 2

1

0

High-throughput

0.513

High

787395

NOL11
Nucleolar protein 11

1

0

High-throughput

0.513

High

787398

SSF1
Suppressor of SWI4 1 homolog

1

0

High-throughput

0.513

High

787387

DVL3
Segment polarity protein dishevelled homolog DVL-3

1

3

High-throughput

0.508

High

787379

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

Small-scale

0.501

High

383668

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

17

High-throughput

0.500

High

526371

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

1

0

High-throughput

0.486

High

787382

HPS6
BLOC-2 complex member HPS6

1

0

High-throughput

0.486

High

148492

CTRO
Citron Rho-interacting kinase

1

5

High-throughput

0.479

High

160426

AURKA
Aurora kinase A

1

8

High-throughput

0.479

High

246185

NBN
Nibrin

1

3

Small-scale

0.479

High

384431

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

506909

LAMP1
Lysosome-associated membrane glycoprotein 1

1

3

High-throughput

0.479

High

787366

KPCE
Protein kinase C epsilon type

1

7

Small-scale

0.479

High

787368

KPCD
Protein kinase C delta type

1

7

Small-scale

0.479

High

787370

TFCP2
Alpha-globin transcription factor CP2

1

2

High-throughput

0.479

High

787373

KIF14
Kinesin-like protein KIF14

1

8

High-throughput

0.479

High

787377

NTRK2
BDNF/NT-3 growth factors receptor

1

20

High-throughput

0.479

High

787392

LPAR5
Lysophosphatidic acid receptor 5

1

20

Small-scale

0.479

High

787397

ECT2
Protein ECT2

1

8

High-throughput

0.479

High

787405

ALK
ALK tyrosine kinase receptor

1

20

Small-scale

0.479

High

787406

GAB2
GRB2-associated-binding protein 2

1

7

Small-scale

0.479

High

787369

DDR1
Epithelial discoidin domain-containing receptor 1

1

20

Small-scale

0.445

High

787372

PAK1
Serine/threonine-protein kinase PAK 1

1

6

Small-scale

0.445

High

787388

SPTCS
Spatacsin

1

0

Small-scale

0.438

High


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Last updated: 15 Jul 2024