Protein: CATL1
Procathepsin L (EC 3.4.22.15) (Cathepsin L1) (Major excreted protein) (MEP) [Cleaved into: Cathepsin L; Cathepsin L heavy chain; Cathepsin L light chain]

Gene: CATL1, CTSL
Organism: Homo sapiens
Interactions: 225
UniProt ID: P07711

Gene Ontology (top 5):
GO:0001968 - fibronectin binding
GO:0002250 - adaptive immune response
GO:0004197 - cysteine-type endopeptidase activity
GO:0005518 - collagen binding
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

261587

CATL2
Cathepsin L2

4

6

High-throughput

0.887

High

459198

CATH
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H

3

6

High-throughput

0.861

High

370261

CYTA
Cystatin-A

3

6

Small-scale

0.857

High

370138

CYTN
Cystatin-SN

3

13

High-throughput

0.855

High

303702

CYTF
Cystatin-F

2

13

High-throughput

0.811

High

459240

CATK
Cathepsin K

2

6

High-throughput

0.811

High

459297

CYTM
Cystatin-M

2

13

High-throughput

0.776

High

459192

CATL1
Procathepsin L

2

6

Small-scale

0.759

High

137372

BT3A3
Butyrophilin subfamily 3 member A3

1

2

High-throughput

0.698

High

370028

CYTC
Cystatin-C

1

13

High-throughput

0.691

High

370396

KNG1
Kininogen-1

1

13

High-throughput

0.691

High

402740

CYTB
Cystatin-B

1

6

High-throughput

0.691

High

459298

GRDN
Girdin

3

4

High-throughput

0.667

High

459253

CLH2
Clathrin heavy chain 2

3

0

High-throughput

0.638

High

459301

CATL3
Putative inactive cathepsin L-like protein CTSL3P

2

7

High-throughput

0.637

High

459207

MPRI
Cation-independent mannose-6-phosphate receptor

2

4

High-throughput

0.621

High

459226

SPB3
Serpin B3

2

2

Small-scale

0.619

High

459304

CREL2
Protein disulfide isomerase CRELD2

2

2

High-throughput

0.576

High

226671

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

5

High-throughput

0.573

High

459270

RELB
Transcription factor RelB

1

3

High-throughput

0.541

High

459319

RSPH1
Radial spoke head 1 homolog

1

1

High-throughput

0.541

High

437620

HEPS
Serine protease hepsin

1

3

High-throughput

0.536

High

459334

TMPSD
Transmembrane protease serine 13

1

3

High-throughput

0.536

High

123558

MYO1C
Unconventional myosin-Ic

1

5

High-throughput

0.515

High

174690

SPTN2
Spectrin beta chain, non-erythrocytic 2

1

6

High-throughput

0.515

High

229622

CALU
Calumenin

1

3

High-throughput

0.515

High

270300

WDR1
WD repeat-containing protein 1

1

1

High-throughput

0.515

High

299909

CBPD
Carboxypeptidase D

1

2

High-throughput

0.515

High

318241

MYO1D
Unconventional myosin-Id

1

5

High-throughput

0.515

High

409219

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

2

High-throughput

0.515

High

413027

P53
Cellular tumor antigen p53

1

1

High-throughput

0.515

High

421322

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.515

High

459193

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

2

High-throughput

0.515

High

459202

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

2

High-throughput

0.515

High

459212

PDIA4
Protein disulfide-isomerase A4

1

8

High-throughput

0.515

High

459213

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

2

High-throughput

0.515

High

459215

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

2

High-throughput

0.515

High

459218

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

3

High-throughput

0.515

High

459224

CALR
Calreticulin

1

6

High-throughput

0.515

High

459237

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

1

High-throughput

0.515

High

459271

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

3

High-throughput

0.515

High

459279

AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

1

2

High-throughput

0.515

High

459285

DX39B
Spliceosome RNA helicase DDX39B

1

2

High-throughput

0.515

High

459291

SYK
Lysine--tRNA ligase

1

2

High-throughput

0.515

High

459295

SAFB1
Scaffold attachment factor B1

1

2

High-throughput

0.515

High

459299

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

2

High-throughput

0.515

High

459318

IPO4
Importin-4

1

1

High-throughput

0.515

High

459344

DJB11
DnaJ homolog subfamily B member 11

1

4

High-throughput

0.515

High

459355

HYOU1
Hypoxia up-regulated protein 1

1

3

High-throughput

0.515

High

387207

APOA1
Apolipoprotein A-I

1

0

High-throughput

0.513

High

389930

ALBU
Albumin

1

0

High-throughput

0.513

High

459256

GEM
GTP-binding protein GEM

1

1

High-throughput

0.508

High

459219

RXRA
Retinoic acid receptor RXR-alpha

1

1

Small-scale

0.501

High

129959

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.493

High

390422

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.493

High

459234

LONM
Lon protease homolog, mitochondrial

1

0

High-throughput

0.493

High

459239

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.493

High

285039

EED
Polycomb protein EED

1

0

High-throughput

0.486

High

459235

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

0

Small-scale

0.486

High

179442

ARPC3
Actin-related protein 2/3 complex subunit 3

1

1

High-throughput

0.479

High

212370

SPIT2
Kunitz-type protease inhibitor 2

1

1

High-throughput

0.479

High

214162

MCA3
Eukaryotic translation elongation factor 1 epsilon-1

1

1

High-throughput

0.479

High

224586

ACTN4
Alpha-actinin-4

1

4

High-throughput

0.479

High

227765

MYO1B
Unconventional myosin-Ib

1

5

High-throughput

0.479

High

251844

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

1

3

High-throughput

0.479

High

258725

DNJA2
DnaJ homolog subfamily A member 2

1

5

High-throughput

0.479

High

321155

ERLN2
Erlin-2

1

4

High-throughput

0.479

High

431657

ITB1
Integrin beta-1

1

1

High-throughput

0.479

High

440298

FYN
Tyrosine-protein kinase Fyn

1

1

High-throughput

0.479

High

459194

LAMB1
Laminin subunit beta-1

1

1

High-throughput

0.479

High

459196

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

1

High-throughput

0.479

High

459205

LAMC1
Laminin subunit gamma-1

1

1

High-throughput

0.479

High

459209

ACTN1
Alpha-actinin-1

1

4

High-throughput

0.479

High

459210

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.479

High

459211

XRCC5
X-ray repair cross-complementing protein 5

1

1

High-throughput

0.479

High

459214

ENPL
Endoplasmin

1

2

High-throughput

0.479

High

459220

MSH3
DNA mismatch repair protein Msh3

1

1

High-throughput

0.479

High

459221

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

2

High-throughput

0.479

High

459228

PDIA3
Protein disulfide-isomerase A3

1

9

High-throughput

0.479

High

459230

PHB1
Prohibitin 1

1

2

High-throughput

0.479

High

459232

BASI
Basigin

1

2

High-throughput

0.479

High

459236

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.479

High

459241

MSH2
DNA mismatch repair protein Msh2

1

1

High-throughput

0.479

High

459242

NAMPT
Nicotinamide phosphoribosyltransferase

1

1

High-throughput

0.479

High

459243

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

2

High-throughput

0.479

High

459248

LMAN1
Protein ERGIC-53

1

1

High-throughput

0.479

High

459249

EFTU
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.479

High

459251

SERPH
Serpin H1

1

4

High-throughput

0.479

High

459255

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

459258

SYMC
Methionine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

459259

RBM11
Splicing regulator RBM11

1

2

High-throughput

0.479

High

459260

RAB10
Ras-related protein Rab-10

1

1

High-throughput

0.479

High

459265

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

1

High-throughput

0.479

High

459266

TPM4
Tropomyosin alpha-4 chain

1

3

High-throughput

0.479

High

459268

PRKDC
DNA-dependent protein kinase catalytic subunit

1

1

High-throughput

0.479

High

459272

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

459273

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

7

High-throughput

0.479

High

459276

CKAP4
Cytoskeleton-associated protein 4

1

5

High-throughput

0.479

High

459277

SSRP1
FACT complex subunit SSRP1

1

2

High-throughput

0.479

High

459278

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

459280

PRDX4
Peroxiredoxin-4

1

1

High-throughput

0.479

High

459284

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

6

High-throughput

0.479

High

459286

SAFB2
Scaffold attachment factor B2

1

2

High-throughput

0.479

High

459289

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

High-throughput

0.479

High

459290

GANAB
Neutral alpha-glucosidase AB

1

1

High-throughput

0.479

High

459293

PON2
Serum paraoxonase/arylesterase 2

1

2

High-throughput

0.479

High

459296

MLF2
Myeloid leukemia factor 2

1

1

High-throughput

0.479

High

459300

TGO1
Transport and Golgi organization protein 1 homolog

1

1

High-throughput

0.479

High

459302

UBR4
E3 ubiquitin-protein ligase UBR4

1

1

High-throughput

0.479

High

459307

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

High-throughput

0.479

High

459309

PLD3
5'-3' exonuclease PLD3

1

1

High-throughput

0.479

High

459310

GCC2
GRIP and coiled-coil domain-containing protein 2

1

4

High-throughput

0.479

High

459311

PELP1
Proline-, glutamic acid- and leucine-rich protein 1

1

1

High-throughput

0.479

High

459317

THOC2
THO complex subunit 2

1

3

High-throughput

0.479

High

459320

MYDGF
Myeloid-derived growth factor

1

1

High-throughput

0.479

High

459323

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

3

High-throughput

0.479

High

459327

RNF5
E3 ubiquitin-protein ligase RNF5

1

2

High-throughput

0.479

High

459336

TMX1
Thioredoxin-related transmembrane protein 1

1

10

High-throughput

0.479

High

459337

GBB4
Guanine nucleotide-binding protein subunit beta-4

1

1

High-throughput

0.479

High

459338

XPO5
Exportin-5

1

2

High-throughput

0.479

High

459339

RAB18
Ras-related protein Rab-18

1

1

High-throughput

0.479

High

459346

ATS1
A disintegrin and metalloproteinase with thrombospondin motifs 1

1

1

High-throughput

0.479

High

459347

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

5

High-throughput

0.479

High

459348

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

3

High-throughput

0.479

High

459350

MYO6
Unconventional myosin-VI

1

1

High-throughput

0.479

High

459351

CHIP
E3 ubiquitin-protein ligase CHIP

1

5

High-throughput

0.479

High

459352

VDAC3
Non-selective voltage-gated ion channel VDAC3

1

2

High-throughput

0.479

High

459356

YTHD2
YTH domain-containing family protein 2

1

3

High-throughput

0.479

High

170624

CLGN
Calmegin

1

6

High-throughput

0.470

High

346810

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.470

High

417214

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

4

High-throughput

0.470

High

417893

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.470

High

459246

SYQ
Glutamine--tRNA ligase

1

2

High-throughput

0.470

High

459294

RCN1
Reticulocalbin-1

1

3

High-throughput

0.470

High

459245

BAG6
Large proline-rich protein BAG6

1

0

High-throughput

0.460

High

162149

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

0

High-throughput

0.458

High

179292

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

High-throughput

0.458

High

209440

SERA
D-3-phosphoglycerate dehydrogenase

1

0

High-throughput

0.458

High

217727

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

228430

LANC1
Glutathione S-transferase LANCL1

1

0

High-throughput

0.458

High

274278

SIN3B
Paired amphipathic helix protein Sin3b

1

0

High-throughput

0.458

High

285561

BAF
Barrier-to-autointegration factor

1

0

High-throughput

0.458

High

403111

APOB
Apolipoprotein B-100

1

0

High-throughput

0.458

High

446362

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.458

High

458657

SAP
Prosaposin

1

0

High-throughput

0.458

High

459197

SNRPA
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.458

High

459199

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

459200

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

0

High-throughput

0.458

High

459201

CO4A
Complement C4-A

1

0

Small-scale

0.458

High

459204

CLUS
Clusterin

1

0

High-throughput

0.458

High

459206

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

0

High-throughput

0.458

High

459216

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

459217

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

459223

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

459225

GRN
Progranulin

1

0

High-throughput

0.458

High

459229

PUR9
Bifunctional purine biosynthesis protein ATIC

1

0

High-throughput

0.458

High

459244

CBX5
Chromobox protein homolog 5

1

0

High-throughput

0.458

High

459247

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

0

High-throughput

0.458

High

459252

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

459254

SYRC
Arginine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

459261

ARP3
Actin-related protein 3

1

0

High-throughput

0.458

High

459262

RHOA
Transforming protein RhoA

1

0

High-throughput

0.458

High

459263

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.458

High

459267

GTF2I
General transcription factor II-I

1

0

High-throughput

0.458

High

459269

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

459274

LGUL
Lactoylglutathione lyase

1

0

High-throughput

0.458

High

459275

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

459287

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

0

High-throughput

0.458

High

459288

DSC3
Desmocollin-3

1

0

High-throughput

0.458

High

459316

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

459322

FAF2
FAS-associated factor 2

1

0

High-throughput

0.458

High

459325

CLCC1
Chloride channel CLIC-like protein 1

1

0

High-throughput

0.458

High

459326

RBM15
RNA-binding protein 15

1

0

High-throughput

0.458

High

459329

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

0

High-throughput

0.458

High

459333

PDIP3
Polymerase delta-interacting protein 3

1

0

High-throughput

0.458

High

459341

T106B
Transmembrane protein 106B

1

0

High-throughput

0.458

High

459342

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

0

High-throughput

0.458

High

459345

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

459349

AKP8L
A-kinase anchor protein 8-like

1

0

High-throughput

0.458

High

459353

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.458

High

459357

SP16H
FACT complex subunit SPT16

1

0

High-throughput

0.458

High

459359

CLIC4
Chloride intracellular channel protein 4

1

0

High-throughput

0.458

High

459195

CATG
Cathepsin G

1

2

High-throughput

0.445

High

459208

ADT3
ADP/ATP translocase 3

1

5

High-throughput

0.445

High

459305

H32
Histone H3.2

1

1

Small-scale

0.445

High

459328

RARR2
Retinoic acid receptor responder protein 2

1

1

Small-scale

0.445

High

174901

SC16A
Protein transport protein Sec16A

1

1

High-throughput

0.437

High

228790

SCO2
Protein SCO2 homolog, mitochondrial

1

1

High-throughput

0.437

High

350570

TXD12
Thioredoxin domain-containing protein 12

1

1

High-throughput

0.437

High

380726

HBD
Hemoglobin subunit delta

1

1

High-throughput

0.437

High

459203

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.437

High

459222

FKBP2
Peptidyl-prolyl cis-trans isomerase FKBP2

1

1

High-throughput

0.437

High

459227

ERP29
Endoplasmic reticulum resident protein 29

1

9

High-throughput

0.437

High

459292

NOMO1
BOS complex subunit NOMO1

1

2

High-throughput

0.437

High

459303

MIC13
MICOS complex subunit MIC13

1

1

High-throughput

0.437

High

459308

YTHD3
YTH domain-containing family protein 3

1

3

High-throughput

0.437

High

459313

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.437

High

459314

TTC13
Tetratricopeptide repeat protein 13

1

4

High-throughput

0.437

High

459331

EFHD1
EF-hand domain-containing protein D1

1

3

High-throughput

0.437

High

459335

YTHD1
YTH domain-containing family protein 1

1

3

High-throughput

0.437

High

459340

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

1

High-throughput

0.437

High

379608

IGHA1
Immunoglobulin heavy constant alpha 1

1

0

High-throughput

0.426

High

390846

TRFE
Serotransferrin

1

0

High-throughput

0.426

High

459315

MCPH1
Microcephalin

1

0

Small-scale

0.251

Low

137618

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.249

Low

272863

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

0

High-throughput

0.249

Low

459231

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

459233

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

0

High-throughput

0.249

Low

459238

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

0

High-throughput

0.249

Low

459250

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.249

Low

459257

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

0

High-throughput

0.249

Low

459264

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

0

High-throughput

0.249

Low

459281

NDK3
Nucleoside diphosphate kinase 3

1

0

High-throughput

0.249

Low

459282

SRSF9
Serine/arginine-rich splicing factor 9

1

0

High-throughput

0.249

Low

459283

CUL2
Cullin-2

1

0

High-throughput

0.249

Low

459306

RIR2B
Ribonucleoside-diphosphate reductase subunit M2 B

1

0

High-throughput

0.249

Low

459312

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

1

0

High-throughput

0.249

Low

459321

NCLN
BOS complex subunit NCLN

1

0

High-throughput

0.249

Low

459324

FMC1
Protein FMC1 homolog

1

0

High-throughput

0.249

Low

459330

NTPCR
Cancer-related nucleoside-triphosphatase

1

0

High-throughput

0.249

Low

459332

WDR18
WD repeat-containing protein 18

1

0

High-throughput

0.249

Low

459343

DHCR7
7-dehydrocholesterol reductase

1

0

High-throughput

0.249

Low

459354

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.249

Low

459358

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025