HitPredict

Interactor 1: AURKA (O14965)
Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A)
Gene: AURKA

Interactor 2: RASF1 (Q9NS23)
Ras association domain-containing protein 1
Gene: RASSF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	28205554, 21874044
Identification Methods	fluorescent resonance energy transfer, enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C1_1~Pkinase, Nore1-SARAH~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005813 - centrosome GO:0015630 - microtubule cytoskeleton
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 403 Hs			1 344
+	Hs
		682035 AKT1_HUMAN (27-401): 3.06e-138: 404: 25.07		RASF1_HUMAN (1-344): 7.96e-150: 427: 100.00
+	Hs
		1292247 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		RASF1_HUMAN (1-344): 7.96e-150: 427: 100.00
+	Hs
		566359 KPCE_HUMAN (4-401): 3.82e-137: 410: 24.33		KPCA_HUMAN (24-266): 3.82e-36: 140: 12.74
+	Hs
		682169 AKT2_HUMAN (27-401): 2.97e-142: 415: 25.00		KPCZ_HUMAN (15-152): 6.03e-34: 133: 24.11
+	Hs
		969095 KPCE_HUMAN (4-401): 3.82e-137: 410: 24.33		GRP3_HUMAN (48-215): 1.37e-34: 135: 20.81
+	Hs
		623873 KPCE_HUMAN (4-401): 3.82e-137: 410: 24.33		KPCL_HUMAN (51-289): 3.04e-34: 134: 17.77
+	Hs
		983943 AKT3_HUMAN (29-401): 1.27e-140: 411: 23.76		KPCZ_HUMAN (15-152): 6.03e-34: 133: 24.11
+	Mm
		682107 AKT1_MOUSE (27-401): 4.36e-139: 407: 24.81		KPCZ_MOUSE (15-152): 4.36e-33: 131: 24.11
+	Hs
		681802 AKT1_HUMAN (27-401): 3.06e-138: 404: 25.07		KPCZ_HUMAN (15-152): 6.03e-34: 133: 24.11
+	Hs
		568728 KAPCA_HUMAN (117-400): 5.82e-136: 394: 29.76		GRP3_HUMAN (48-215): 1.37e-34: 135: 20.81
+	Hs
		568636 KAPCA_HUMAN (117-400): 5.82e-136: 394: 29.76		KPCZ_HUMAN (15-152): 6.03e-34: 133: 24.11
+	Hs
		610716 KAPCB_HUMAN (117-400): 2.4e-135: 393: 30.80		KPCZ_HUMAN (15-152): 6.03e-34: 133: 24.11
+	Hs
		969083 KPCE_HUMAN (4-401): 3.82e-137: 410: 24.33		KPCD1_HUMAN (50-183): 2.44e-19: 91: 19.40
+	Hs
		969068 KPCE_HUMAN (4-401): 3.82e-137: 410: 24.33		KPCE_HUMAN (27-107): 4.59e-13: 72.2: 31.33
+	Mm
		554867 AKT1_MOUSE (27-401): 4.36e-139: 407: 24.81		KPCE_MOUSE (27-107): 4.01e-13: 72.2: 31.33
+	Hs
		681803 AKT1_HUMAN (27-401): 3.06e-138: 404: 25.07		KPCD_HUMAN (23-114): 2.53e-12: 69.9: 21.74
+	Hs
		681799 AKT1_HUMAN (27-401): 3.06e-138: 404: 25.07		KPCT_HUMAN (30-114): 9.76e-11: 64.9: 27.06