Protein: EDN3
Endothelin-3 (ET-3) (Preproendothelin-3) (PPET3)

Gene: EDN3
Organism: Homo sapiens
Interactions: 107
UniProt ID: P14138

Gene Ontology (top 5):
GO:0001755 - neural crest cell migration
GO:0002690 - positive regulation of leukocyte chemotaxis
GO:0003100 - regulation of systemic arterial blood pressure by endothelin
GO:0005102 - signaling receptor binding
GO:0005179 - hormone activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

570649

EDNRB
Endothelin receptor type B

1

2

Small-scale

0.647

High

551834

CO6A2

2

1

High-throughput

0.601

High

570656

LAMB2
Laminin subunit beta-2

2

3

High-throughput

0.601

High

570688

MEGF8
Multiple epidermal growth factor-like domains protein 8

2

7

High-throughput

0.601

High

570700

KREM2
Kremen protein 2

2

1

High-throughput

0.601

High

570706

RSPRY
RING finger and SPRY domain-containing protein 1

2

0

High-throughput

0.576

High

136815

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

4

High-throughput

0.536

High

183223

LAMA5
Laminin subunit alpha-5

1

6

High-throughput

0.536

High

274854

LRP5
Low-density lipoprotein receptor-related protein 5

1

3

High-throughput

0.536

High

287518

LRP6
Low-density lipoprotein receptor-related protein 6

1

3

High-throughput

0.536

High

296339

ATRN
Attractin

1

6

High-throughput

0.536

High

335377

GDF11
Growth/differentiation factor 11

1

1

High-throughput

0.536

High

336184

TNF6B
Tumor necrosis factor receptor superfamily member 6B

1

1

High-throughput

0.536

High

376695

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

1

High-throughput

0.536

High

421425

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.536

High

452079

PROS
Vitamin K-dependent protein S

1

4

High-throughput

0.536

High

457204

TBB5
Tubulin beta chain

1

1

High-throughput

0.536

High

467813

BGLR
Beta-glucuronidase

1

1

High-throughput

0.536

High

551752

CO6A1

1

1

High-throughput

0.536

High

570645

ARSA
Arylsulfatase A

1

1

High-throughput

0.536

High

570647

FGFR4
Fibroblast growth factor receptor 4

1

1

High-throughput

0.536

High

570648

FGFR3
Fibroblast growth factor receptor 3

1

1

High-throughput

0.536

High

570650

PCSK6
Proprotein convertase subtilisin/kexin type 6

1

2

High-throughput

0.536

High

570654

NOTC1
Neurogenic locus notch homolog protein 1

1

3

High-throughput

0.536

High

570658

TBA4A
Tubulin alpha-4A chain

1

3

High-throughput

0.536

High

570659

CNTP1
Contactin-associated protein 1

1

5

High-throughput

0.536

High

570660

PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein

1

2

High-throughput

0.536

High

570663

NOTC2
Neurogenic locus notch homolog protein 2

1

2

High-throughput

0.536

High

570665

SEM3B
Semaphorin-3B

1

1

High-throughput

0.536

High

570666

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

2

High-throughput

0.536

High

570667

TBB3
Tubulin beta-3 chain

1

1

High-throughput

0.536

High

570669

LAMB3
Laminin subunit beta-3

1

4

High-throughput

0.536

High

570670

GAS6
Growth arrest-specific protein 6

1

6

High-throughput

0.536

High

570683

ARSK
Arylsulfatase K

1

1

High-throughput

0.536

High

570684

CREL2
Protein disulfide isomerase CRELD2

1

2

High-throughput

0.536

High

570695

VWDE
von Willebrand factor D and EGF domain-containing protein

1

4

High-throughput

0.536

High

570698

PCSK9
Proprotein convertase subtilisin/kexin type 9

1

1

High-throughput

0.536

High

570702

SORL
Sortilin-related receptor

1

3

High-throughput

0.536

High

570715

CHRD
Chordin

1

2

High-throughput

0.536

High

570723

ATS7
A disintegrin and metalloproteinase with thrombospondin motifs 7

1

2

High-throughput

0.536

High

62897

POTEF
POTE ankyrin domain family member F

1

0

High-throughput

0.513

High

350681

NOE2
Noelin-2

1

0

High-throughput

0.513

High

472164

TRFM
Melanotransferrin

1

0

High-throughput

0.513

High

562690

BMP1
Bone morphogenetic protein 1

1

0

High-throughput

0.513

High

570652

ACHA5
Neuronal acetylcholine receptor subunit alpha-5

1

0

High-throughput

0.513

High

570661

DIAC
Di-N-acetylchitobiase

1

0

High-throughput

0.513

High

570674

PRSS8
Prostasin

1

0

High-throughput

0.513

High

570675

TECT1
Tectonic-1

1

0

High-throughput

0.513

High

570692

CILP2
Cartilage intermediate layer protein 2

1

0

High-throughput

0.513

High

570707

TRI11
E3 ubiquitin-protein ligase TRIM11

1

0

High-throughput

0.513

High

570708

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.513

High

570722

METRN
Meteorin

1

0

High-throughput

0.513

High

570726

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.513

High

136592

MANBA
Beta-mannosidase

1

1

High-throughput

0.489

High

160802

TOR1B
Torsin-1B

1

1

High-throughput

0.489

High

376471

LDLR
Low-density lipoprotein receptor

1

3

High-throughput

0.489

High

570664

APLP2
Amyloid beta precursor like protein 2

1

1

High-throughput

0.489

High

570678

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

1

1

High-throughput

0.489

High

570685

DUSTY
Dual serine/threonine and tyrosine protein kinase

1

1

High-throughput

0.489

High

570686

THSD4
Thrombospondin type-1 domain-containing protein 4

1

2

High-throughput

0.489

High

570687

TBA1A
Tubulin alpha-1A chain

1

3

High-throughput

0.489

High

570690

ANR46
Ankyrin repeat domain-containing protein 46

1

1

High-throughput

0.489

High

570693

P3H3
Prolyl 3-hydroxylase 3

1

1

High-throughput

0.489

High

570697

SUMF1
Formylglycine-generating enzyme

1

1

High-throughput

0.489

High

570703

SC65
Endoplasmic reticulum protein SC65

1

1

High-throughput

0.489

High

570711

TBA1C
Tubulin alpha-1C chain

1

3

High-throughput

0.489

High

570712

CSTN3
Calsyntenin-3

1

1

High-throughput

0.489

High

570713

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

1

High-throughput

0.489

High

570716

TOR3A
Torsin-3A

1

1

High-throughput

0.489

High

570717

TBB1
Tubulin beta-1 chain

1

3

High-throughput

0.489

High

570724

JAG2
Protein jagged-2

1

2

High-throughput

0.489

High

570657

ATS12
A disintegrin and metalloproteinase with thrombospondin motifs 12

1

2

High-throughput

0.445

High

570671

LTBP2
Latent-transforming growth factor beta-binding protein 2

1

3

High-throughput

0.445

High

570718

SEM4B
Semaphorin-4B

1

1

High-throughput

0.445

High

570651

CCN2
CCN family member 2

1

0

High-throughput

0.426

High

570696

SUMF2
Inactive C-alpha-formylglycine-generating enzyme 2

1

1

High-throughput

0.407

High

244439

MGRN1
E3 ubiquitin-protein ligase MGRN1

2

0

High-throughput

0.313

High

570691

FBX11
F-box only protein 11

2

0

High-throughput

0.313

High

158976

ZN195
Zinc finger protein 195

1

0

High-throughput

0.279

Low

239481

H6ST1
Heparan-sulfate 6-O-sulfotransferase 1

1

0

High-throughput

0.279

Low

359789

DYR
Dihydrofolate reductase

1

0

High-throughput

0.279

Low

570646

NAGAB
Alpha-N-acetylgalactosaminidase

1

0

High-throughput

0.279

Low

570655

ANAG
Alpha-N-acetylglucosaminidase

1

0

High-throughput

0.279

Low

570662

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.279

Low

570668

ITA7
Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]

1

0

High-throughput

0.279

Low

570672

CND1
Condensin complex subunit 1

1

0

High-throughput

0.279

Low

570673

OZF
Zinc finger protein OZF

1

0

High-throughput

0.279

Low

570676

OFUT4
GDP-fucose protein O-fucosyltransferase 4

1

0

High-throughput

0.279

Low

570677

TGO1
Transport and Golgi organization protein 1 homolog

1

0

High-throughput

0.279

Low

570679

GT253
Inactive glycosyltransferase 25 family member 3

1

0

High-throughput

0.279

Low

570680

AB17B
Alpha/beta hydrolase domain-containing protein 17B

1

0

High-throughput

0.279

Low

570681

GLT18
Polypeptide N-acetylgalactosaminyltransferase 18

1

0

High-throughput

0.279

Low

570682

PLGT2
Protein O-glucosyltransferase 2

1

0

High-throughput

0.279

Low

570689

OAF
Out at first protein homolog

1

0

High-throughput

0.279

Low

570694

TRM44
Probable tRNA

1

0

High-throughput

0.279

Low

570699

UXS1
UDP-glucuronic acid decarboxylase 1

1

0

High-throughput

0.279

Low

570701

NEK9
Serine/threonine-protein kinase Nek9

1

0

High-throughput

0.279

Low

570704

N42L2
NEDD4-binding protein 2-like 2

1

0

High-throughput

0.279

Low

570705

EXT2
Exostosin-2

1

0

High-throughput

0.279

Low

570709

DDX11
ATP-dependent DNA helicase DDX11

1

0

High-throughput

0.279

Low

570710

RBM14
RNA-binding protein 14

1

0

High-throughput

0.279

Low

570714

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

1

0

High-throughput

0.279

Low

570719

CELR1
Cadherin EGF LAG seven-pass G-type receptor 1

1

0

High-throughput

0.279

Low

570720

SELN
Selenoprotein N

1

0

High-throughput

0.279

Low

570721

SUN2
SUN domain-containing protein 2

1

0

High-throughput

0.279

Low

570725

MA2B2
Epididymis-specific alpha-mannosidase

1

0

High-throughput

0.279

Low

570653

NAA10
N-alpha-acetyltransferase 10

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025