HitPredict

Interactor 1: XPO1 (O14980)
Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog)
Gene: XPO1

Interactor 2: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37516964
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1071 Hs			1 3969
+	Hs
		162782 XPO1_HUMAN (1-1071): 0: 1022: 100.00		EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54
+	Hs
		163234 XPO1_HUMAN (1-1071): 0: 1022: 100.00		SETD2_HUMAN (3398-3968): 1.14e-75: 285: 16.61
+	Hs
		1080201 TNPO1_HUMAN (33-1045): 1.81e-132: 425: 13.84		EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54
+	Hs
		1060762 IMB1_HUMAN (27-908): 2.89e-90: 311: 11.32		EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54
+	Mm
		936158 IMB1_MOUSE (27-908): 2.4e-91: 313: 11.43		Q6AXH7_MOUSE (3450-3951): 9.61e-104: 354: 18.18
+	Mm
		93312 XPO7_MOUSE (23-1013): 5.43e-120: 397: 13.01		SET1A_MOUSE (3607-3969): 7.97e-64: 245: 29.77