HitPredict

Interactor 1: XPO1 (O14980)
Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog)
Gene: XPO1

Interactor 2: NED4L (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
Gene: NEDD4L

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	26673895
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1071 Hs			1 975
+	Xl
		1151479 Q6NS03_XENLA (1-1071): 0: 1007: 97.01		Q6GMD5_XENLA (7-975): 0: 1003: 89.69
+	Hs
		162492 XPO1_HUMAN (1-1071): 0: 1022: 100.00		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		162930 XPO1_HUMAN (1-1071): 0: 1022: 100.00		HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26
+	Hs
		163312 XPO1_HUMAN (1-1071): 0: 1022: 100.00		SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71
+	Hs
		163304 XPO1_HUMAN (1-1071): 0: 1022: 100.00		SMUF2_HUMAN (21-324): 2e-29: 127: 22.56
+	Hs
		1060871 IMB1_HUMAN (27-908): 2.89e-90: 311: 11.32		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		1060804 IMB1_HUMAN (27-908): 2.89e-90: 311: 11.32		HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26
+	Hs
		1060932 IMB1_HUMAN (27-908): 2.89e-90: 311: 11.32		SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71
+	Hs
		1334886 TNPO3_HUMAN (24-901): 9.93e-89: 307: 14.37		SMUF2_HUMAN (21-324): 2e-29: 127: 22.56