Interactor 1: SPTN2 (O15020)
Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein)
Gene: SPTBN2

Interactor 2: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.68 1.00 0.829

The method score is based on:

Property Details
Experiments 37071682, 17607528, 35235311
Identification Methods cross-linking study, two hybrid
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains CH~EF-hand_7, CH~EFhand_Ca_insen, CH~Spectrin, EFhand_Ca_insen~Spectrin, Spectrin~Spectrin
Common GO terms GO:0003779 - actin binding
GO:0005200 - structural constituent of cytoskeleton
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0008091 - spectrin
and 8 others

more...

Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 2390
Hs

1 2472
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024