HitPredict

Interactor 1: SET1A (O15047)
Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1)
Gene: SETD1A

Interactor 2: RBBP5 (Q15291)
Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3)
Gene: RBBP5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.985

Property	Details
Experiments	23453808, 23870121, 27563068, 29785026, 29474905, 31076518, 16253997, 17355966, 17998332, 20516061, 22147691, 21653943, 24981860, 33961781, 23508102, 37689310, 20305087
Identification Methods	pull down, affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	N-SET~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006974 - DNA damage response GO:0035097 - histone methyltransferase complex GO:0048188 - Set1C/COMPASS complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1707 Hs			1 538
+	Mm
		876680 KMT2A_MOUSE (1029-1707): 3.02e-77: 287: 22.24		RBBP5_MOUSE (1-538): 9.56e-137: 408: 99.07
+	Hs
		1070808 KMT2B_HUMAN (1010-1707): 4.16e-74: 277: 22.55		RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00
+	Hs
		975258 KMT2A_HUMAN (1094-1707): 3.48e-69: 261: 21.28		RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00
+	Hs
		1070809 SET1B_HUMAN (257-1707): 2.03e-55: 216: 23.18		RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00
+	Hs
		165657 SET1A_HUMAN (1-1707): 6.31e-168: 556: 100.00		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41
+	Sp
		194056 SET1_SCHPO (1173-1707): 7.33e-76: 275: 27.60		SWD1_SCHPO (1-392): 1.06e-88: 280: 32.68
+	Sc
		755771 SET1_YEAST (1286-1707): 1.12e-70: 261: 27.36		SWD1_YEAST (1-356): 1.48e-77: 252: 30.08
+	Hs
		203735 SUV91_HUMAN (1506-1706): 1.66e-73: 253: 22.75		DAW1_HUMAN (54-395): 7.21e-75: 244: 15.12
+	Zm
		35725 A0A1D6M742_MAIZE (1110-1704): 9.65e-64: 233: 13.10		A0A1D6LQJ4_MAIZE (100-413): 7.31e-51: 179: 9.66
+	At
		1319861 ATX1_ARATH (1473-1707): 3.76e-65: 244: 31.41		WDR5A_ARATH (182-434): 2.41e-37: 142: 16.93
+	Hs
		1288387 KMT2B_HUMAN (1010-1707): 4.16e-74: 277: 22.55		SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59
+	Hs
		975304 KMT2A_HUMAN (1094-1707): 3.48e-69: 261: 21.28		SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59
+	Hs
		1080207 EZH2_HUMAN (1161-1690): 6.02e-75: 268: 14.71		FBXW7_HUMAN (279-521): 2.8e-16: 83.9: 10.56
+	Hs
		1080166 EZH2_HUMAN (1161-1690): 6.02e-75: 268: 14.71		PHIP_HUMAN (227-374): 6.69e-15: 80.4: 13.91
+	Hs
		975303 KMT2A_HUMAN (1094-1707): 3.48e-69: 261: 21.28		FBXW7_HUMAN (279-521): 2.8e-16: 83.9: 10.56
+	Hs
		903604 KMT2B_HUMAN (1010-1707): 4.16e-74: 277: 22.55		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41
+	Hs
		331862 NSD2_HUMAN (1405-1706): 1.62e-63: 241: 19.94		SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59
+	Hs
		903149 KMT2A_HUMAN (1094-1707): 3.48e-69: 261: 21.28		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41
+	Hs
		1288292 NSD3_HUMAN (1561-1706): 5.1e-55: 213: 30.20		SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59
+	Hs
		903609 SET1B_HUMAN (257-1707): 2.03e-55: 216: 23.18		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41