Protein: SCO1
Protein SCO1 homolog, mitochondrial

Gene: SCO1
Organism: Homo sapiens
Interactions: 178
UniProt ID: O75880

Gene Ontology (top 5):
GO:0005507 - copper ion binding
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0006878 - intracellular copper ion homeostasis
GO:0016531 - copper chaperone activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

228773

SCO2
Protein SCO2 homolog, mitochondrial

1

4

High-throughput

0.618

High

296172

SCO1
Protein SCO1 homolog, mitochondrial

1

4

High-throughput

0.618

High

296239

COX17
Cytochrome c oxidase copper chaperone

2

1

Small-scale

0.611

High

275214

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

2

0

High-throughput

0.585

High

292042

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

2

2

High-throughput

0.584

High

296303

SFXN1
Sideroflexin-1

2

1

High-throughput

0.584

High

283737

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

2

0

High-throughput

0.559

High

296262

COX15
Heme A synthase COX15

2

0

High-throughput

0.559

High

296315

OCAD1
OCIA domain-containing protein 1

2

0

High-throughput

0.559

High

296319

CIDEB
Lipid transferase CIDEB

2

1

High-throughput

0.553

High

296178

EYA4
Protein phosphatase EYA4

2

3

High-throughput

0.533

High

165684

PPE1
Serine/threonine-protein phosphatase with EF-hands 1

1

1

High-throughput

0.489

High

124563

EYA2
Protein phosphatase EYA2

1

3

High-throughput

0.479

High

137589

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

1

High-throughput

0.479

High

238688

TIM8A
Mitochondrial import inner membrane translocase subunit Tim8 A

1

2

High-throughput

0.479

High

281551

MTX2
Metaxin-2

1

1

High-throughput

0.479

High

296175

GLSK
Glutaminase kidney isoform, mitochondrial

1

5

High-throughput

0.479

High

296181

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

1

High-throughput

0.479

High

296184

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

1

1

High-throughput

0.479

High

296187

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

1

High-throughput

0.479

High

296195

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

1

High-throughput

0.479

High

296201

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

1

High-throughput

0.479

High

296202

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

1

High-throughput

0.479

High

296209

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

296213

ACOT2
Acyl-coenzyme A thioesterase 2, mitochondrial

1

1

High-throughput

0.479

High

296236

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

296251

MTX3
Metaxin-3

1

1

High-throughput

0.479

High

296252

COA6
Cytochrome c oxidase assembly factor 6 homolog

1

1

High-throughput

0.479

High

296259

MIC27
MICOS complex subunit MIC27

1

1

High-throughput

0.479

High

296264

ACOT1
Acyl-coenzyme A thioesterase 1

1

1

High-throughput

0.479

High

296266

MICU2
Calcium uptake protein 2, mitochondrial

1

5

High-throughput

0.479

High

296278

P5CR2
Pyrroline-5-carboxylate reductase 2

1

1

High-throughput

0.479

High

296282

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

1

High-throughput

0.479

High

296287

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

296288

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

1

High-throughput

0.479

High

296290

MIC25
MICOS complex subunit MIC25

1

1

High-throughput

0.479

High

296292

MIC26
MICOS complex subunit MIC26

1

1

High-throughput

0.479

High

296296

CLPB
Mitochondrial disaggregase

1

2

High-throughput

0.479

High

296297

BRD8
Bromodomain-containing protein 8

1

3

High-throughput

0.479

High

296298

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

4

High-throughput

0.479

High

296299

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

1

High-throughput

0.479

High

296302

OPA3
Optic atrophy 3 protein

1

1

High-throughput

0.479

High

296312

DJC11
DnaJ homolog subfamily C member 11

1

5

High-throughput

0.479

High

296316

MIC19
MICOS complex subunit MIC19

1

1

High-throughput

0.479

High

296320

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

2

High-throughput

0.479

High

296324

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

1

High-throughput

0.479

High

296327

TIM8B
Mitochondrial import inner membrane translocase subunit Tim8 B

1

2

High-throughput

0.479

High

296328

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

2

High-throughput

0.479

High

296329

COX11
Cytochrome c oxidase assembly protein COX11, mitochondrial

1

1

High-throughput

0.479

High

124172

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.458

High

225156

TRIA1
TP53-regulated inhibitor of apoptosis 1

1

0

High-throughput

0.458

High

245393

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

0

High-throughput

0.458

High

256215

RT14
Small ribosomal subunit protein uS14m

1

0

High-throughput

0.458

High

275587

NDUS2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

1

0

High-throughput

0.458

High

278591

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

1

0

High-throughput

0.458

High

296173

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

0

High-throughput

0.458

High

296174

TOM70
Mitochondrial import receptor subunit TOM70

1

0

High-throughput

0.458

High

296176

NDUA7
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

1

0

High-throughput

0.458

High

296177

LETM1
Mitochondrial proton/calcium exchanger protein

1

0

High-throughput

0.458

High

296180

SNP29
Synaptosomal-associated protein 29

1

0

High-throughput

0.458

High

296188

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.458

High

296189

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

296190

CX6B1
Cytochrome c oxidase subunit 6B1

1

0

High-throughput

0.458

High

296192

ATP5J
ATP synthase peripheral stalk subunit F6, mitochondrial

1

0

High-throughput

0.458

High

296193

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

0

High-throughput

0.458

High

296197

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

0

High-throughput

0.458

High

296199

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

0

High-throughput

0.458

High

296206

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

0

High-throughput

0.458

High

296207

HEM6
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

1

0

High-throughput

0.458

High

296208

ETFB
Electron transfer flavoprotein subunit beta

1

0

High-throughput

0.458

High

296211

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

0

High-throughput

0.458

High

296215

NDUA8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

1

0

High-throughput

0.458

High

296216

CCHL
Holocytochrome c-type synthase

1

0

High-throughput

0.458

High

296218

KAD2
Adenylate kinase 2, mitochondrial

1

0

High-throughput

0.458

High

296219

ALR
FAD-linked sulfhydryl oxidase ALR

1

0

High-throughput

0.458

High

296220

CMC4
Cx9C motif-containing protein 4

1

0

High-throughput

0.458

High

296224

TIM10
Mitochondrial import inner membrane translocase subunit Tim10

1

0

High-throughput

0.458

High

296227

RT22
Small ribosomal subunit protein mS22

1

0

High-throughput

0.458

High

296228

KGD4
Alpha-ketoglutarate dehydrogenase component 4

1

0

High-throughput

0.458

High

296229

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

296234

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

0

High-throughput

0.458

High

296240

NUCG
Endonuclease G, mitochondrial

1

0

High-throughput

0.458

High

296242

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

High-throughput

0.458

High

296243

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.458

High

296245

NDUA5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

1

0

High-throughput

0.458

High

296246

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.458

High

296247

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

296248

COX19
Cytochrome c oxidase assembly protein COX19

1

0

High-throughput

0.458

High

296249

MIX23
Protein MIX23

1

0

High-throughput

0.458

High

296255

ATD3B
ATPase family AAA domain-containing protein 3B

1

0

High-throughput

0.458

High

296257

TTC19
Tetratricopeptide repeat protein 19, mitochondrial

1

0

High-throughput

0.458

High

296263

MAVS
Mitochondrial antiviral-signaling protein

1

0

High-throughput

0.458

High

296265

T126B
Complex I assembly factor TMEM126B, mitochondrial

1

0

High-throughput

0.458

High

296268

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.458

High

296272

RT31
Small ribosomal subunit protein mS31

1

0

High-throughput

0.458

High

296273

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.458

High

296275

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.458

High

296276

COA7
Cytochrome c oxidase assembly factor 7

1

0

High-throughput

0.458

High

296277

F136A
Protein FAM136A

1

0

High-throughput

0.458

High

296279

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.458

High

296280

MITOK
Mitochondrial potassium channel

1

0

High-throughput

0.458

High

296281

SIM12
Small integral membrane protein 12

1

0

High-throughput

0.458

High

296283

PTCD3
Small ribosomal subunit protein mS39

1

0

High-throughput

0.458

High

296286

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

296291

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

296294

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

0

High-throughput

0.458

High

296304

PLRKT
Plasminogen receptor

1

0

High-throughput

0.458

High

296306

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

1

0

High-throughput

0.458

High

296308

COXM2
COX assembly mitochondrial protein 2 homolog

1

0

High-throughput

0.458

High

296310

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.458

High

296311

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

296317

COX16
Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial

1

0

High-throughput

0.458

High

296323

RT23
Small ribosomal subunit protein mS23

1

0

High-throughput

0.458

High

296325

SAM50
Sorting and assembly machinery component 50 homolog

1

0

High-throughput

0.458

High

296326

TIM9
Mitochondrial import inner membrane translocase subunit Tim9

1

0

High-throughput

0.458

High

296244

NTRK3
NT-3 growth factor receptor

1

4

High-throughput

0.457

High

296196

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.445

High

156784

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.437

High

250376

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

1

High-throughput

0.437

High

296179

BRD1
Bromodomain-containing protein 1

1

3

High-throughput

0.437

High

296191

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

296198

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

296205

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

296212

NASP
Nuclear autoantigenic sperm protein

1

1

High-throughput

0.437

High

296222

CDC42
Cell division control protein 42 homolog

1

2

High-throughput

0.437

High

296223

RHOA
Transforming protein RhoA

1

2

High-throughput

0.437

High

296225

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.437

High

296230

RHOG
Rho-related GTP-binding protein RhoG

1

2

High-throughput

0.437

High

296232

AKA12
A-kinase anchor protein 12

1

1

High-throughput

0.437

High

296235

MTM1
Myotubularin

1

4

High-throughput

0.437

High

296253

WIPI1
WD repeat domain phosphoinositide-interacting protein 1

1

1

Small-scale

0.437

High

296284

AURKB
Aurora kinase B

1

2

High-throughput

0.437

High

296293

MTMRC
Myotubularin-related protein 12

1

4

High-throughput

0.437

High

296301

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.437

High

296307

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

2

High-throughput

0.437

High

296309

TMPS4
Transmembrane protease serine 4

1

1

High-throughput

0.437

High

296313

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

1

High-throughput

0.437

High

296318

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.437

High

296183

TNNC2
Troponin C, skeletal muscle

1

2

High-throughput

0.407

High

296185

CALM2
Calmodulin-2

1

1

High-throughput

0.407

High

296186

CALM3
Calmodulin-3

1

1

High-throughput

0.407

High

296221

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.407

High

296250

S39AC
Zinc transporter ZIP12

1

2

High-throughput

0.407

High

296271

S39A7
Zinc transporter SLC39A7

1

2

High-throughput

0.407

High

296285

S39AD
Zinc transporter ZIP13

1

2

High-throughput

0.407

High

296321

ST38L
Serine/threonine-protein kinase 38-like

1

2

High-throughput

0.407

High

296214

CAV2
Caveolin-2

2

0

High-throughput

0.298

High

296269

WDR19
WD repeat-containing protein 19

1

0

High-throughput

0.279

Low

296305

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.279

Low

296194

COMT
Catechol O-methyltransferase

1

0

High-throughput

0.268

Low

164198

NRP1
Neuropilin-1

1

0

High-throughput

0.249

Low

174869

SC16A
Protein transport protein Sec16A

1

0

High-throughput

0.249

Low

296182

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.249

Low

296203

HSP74
Heat shock 70 kDa protein 4

1

0

High-throughput

0.249

Low

296204

RADI
Radixin

1

0

High-throughput

0.249

Low

296217

ATX1
Ataxin-1

1

0

High-throughput

0.249

Low

296226

RL38
Large ribosomal subunit protein eL38

1

0

High-throughput

0.249

Low

296231

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.249

Low

296238

FHL3
Four and a half LIM domains protein 3

1

0

High-throughput

0.249

Low

296241

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.249

Low

296254

UBR4
E3 ubiquitin-protein ligase UBR4

1

0

High-throughput

0.249

Low

296256

CRBG3
Very large A-kinase anchor protein

1

0

High-throughput

0.249

Low

296260

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

296267

NUP93
Nuclear pore complex protein Nup93

1

0

High-throughput

0.249

Low

296270

TITIN
Titin

1

0

High-throughput

0.249

Low

296274

SYAP1
Synapse-associated protein 1

1

0

High-throughput

0.249

Low

296289

CDCA3
Cell division cycle-associated protein 3

1

0

High-throughput

0.249

Low

296295

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

296300

CA198
Uncharacterized protein C1orf198

1

0

High-throughput

0.249

Low

296314

DJC28
DnaJ homolog subfamily C member 28

1

0

High-throughput

0.249

Low

296322

TMA7
Translation machinery-associated protein 7

1

0

High-throughput

0.249

Low

296200

CTR1
High affinity cationic amino acid transporter 1

1

0

High-throughput

0.232

Low

296210

EAA2
Excitatory amino acid transporter 2

1

0

High-throughput

0.232

Low

296233

TNR9
Tumor necrosis factor receptor superfamily member 9

1

0

High-throughput

0.232

Low

296237

RAB31
Ras-related protein Rab-31

1

0

High-throughput

0.232

Low

296258

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.232

Low

296261

CC062
Uncharacterized protein C3orf62

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025