HitPredict

Interactor 1: SYNEM (O15061)
Synemin (Desmuslin)
Gene: SYNM

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.50	0.533

Property	Details
Experiments	17437541, 8552632
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1565 Hs			1 217
+	Hs
		359329 K1C14_HUMAN (9-349): 1.21e-141: 446: 23.98		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924493 K1C17_HUMAN (6-328): 7.11e-138: 434: 26.54		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		445027 K1C16_HUMAN (7-336): 6.38e-136: 430: 25.68		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		580010 K1C15_HUMAN (10-325): 6.11e-136: 429: 24.21		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		444346 K1C19_HUMAN (6-330): 8.56e-134: 421: 23.01		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924574 KT33B_HUMAN (9-319): 1.97e-133: 421: 26.60		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Mm
		1060206 Q148Q7_MOUSE (8-331): 1.02e-101: 338: 22.22		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Hs
		280492 KT33A_HUMAN (9-332): 4.58e-101: 332: 25.23		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Mm
		403444 K1C14_MOUSE (10-322): 2.47e-136: 432: 24.84		SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		275168 K1C13_HUMAN (6-335): 3.69e-135: 427: 22.89		GRAP2_HUMAN (3-55): 1.58e-10: 61.3: 39.62
+	Hs
		280786 KRT36_HUMAN (11-322): 1.75e-63: 226: 24.92		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		531551 K2C5_HUMAN (4-325): 2.24e-60: 220: 18.83		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		359480 K2C6A_HUMAN (4-325): 1.18e-59: 218: 19.44		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		443451 VIME_HUMAN (11-320): 2.95e-31: 131: 33.44		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		280771 KRT36_HUMAN (11-322): 1.75e-63: 226: 24.92		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Mm
		403456 K2C5_MOUSE (4-325): 6.57e-59: 216: 18.83		SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		443382 VIME_HUMAN (11-320): 2.95e-31: 131: 33.44		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Hs
		411976 GFAP_HUMAN (11-320): 4.41e-27: 118: 32.58		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		433235 GFAP_HUMAN (11-320): 4.41e-27: 118: 32.58		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Hs
		275169 GFAP_HUMAN (11-320): 4.41e-27: 118: 32.58		GRAP2_HUMAN (3-55): 1.58e-10: 61.3: 39.62