Protein: AIM2
Interferon-inducible protein AIM2 (Absent in melanoma 2)

Gene: AIM2
Organism: Homo sapiens
Interactions: 119
UniProt ID: O14862

Gene Ontology (top 5):
GO:0002218 - activation of innate immune response
GO:0002221 - pattern recognition receptor signaling pathway
GO:0002230 - positive regulation of defense response to virus by host
GO:0003690 - double-stranded DNA binding
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

166206

ASC
Apoptosis-associated speck-like protein containing a CARD

6

2

Small-scale

0.956

High

166096

AIM2
Interferon-inducible protein AIM2

4

4

Small-scale

0.881

High

166148

SQSTM
Sequestosome-1

3

2

Small-scale

0.660

High

166186

TRI11
E3 ubiquitin-protein ligase TRIM11

2

3

Small-scale

0.584

High

123010

DX39A
ATP-dependent RNA helicase DDX39A

1

3

High-throughput

0.536

High

139432

PESC
Pescadillo homolog

1

3

High-throughput

0.536

High

140056

SDCB1
Syntenin-1

1

1

High-throughput

0.536

High

166097

HAT1
Histone acetyltransferase type B catalytic subunit

1

2

High-throughput

0.536

High

166101

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

10

High-throughput

0.536

High

166102

NBN
Nibrin

1

1

High-throughput

0.536

High

166105

MTA2
Metastasis-associated protein MTA2

1

3

High-throughput

0.536

High

166106

PHF14
PHD finger protein 14

1

3

High-throughput

0.536

High

166107

JUN
Transcription factor Jun

1

3

High-throughput

0.536

High

166108

AP2A
Transcription factor AP-2-alpha

1

2

High-throughput

0.536

High

166110

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

2

High-throughput

0.536

High

166112

XRCC6
X-ray repair cross-complementing protein 6

1

5

High-throughput

0.536

High

166113

XRCC5
X-ray repair cross-complementing protein 5

1

5

High-throughput

0.536

High

166114

RINI
Ribonuclease inhibitor

1

2

High-throughput

0.536

High

166115

TRI27
Zinc finger protein RFP

1

5

High-throughput

0.536

High

166119

CSK22
Casein kinase II subunit alpha'

1

4

High-throughput

0.536

High

166120

COT2
COUP transcription factor 2

1

3

High-throughput

0.536

High

166121

EF1B
Elongation factor 1-beta

1

1

High-throughput

0.536

High

166123

PML
Protein PML

1

5

High-throughput

0.536

High

166124

HXA13
Homeobox protein Hox-A13

1

1

High-throughput

0.536

High

166126

MTREX
Exosome RNA helicase MTR4

1

13

High-throughput

0.536

High

166127

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.536

High

166128

CTCF
Transcriptional repressor CTCF

1

3

High-throughput

0.536

High

166129

NU153
Nuclear pore complex protein Nup153

1

8

High-throughput

0.536

High

166130

DNLI3
DNA ligase 3

1

2

High-throughput

0.536

High

166131

MRE11
Double-strand break repair protein MRE11

1

1

High-throughput

0.536

High

166133

MECP2
Methyl-CpG-binding protein 2

1

4

High-throughput

0.536

High

166135

MSH6
DNA mismatch repair protein Msh6

1

4

High-throughput

0.536

High

166136

COPA
Coatomer subunit alpha

1

5

High-throughput

0.536

High

166137

HIRA
Protein HIRA

1

5

High-throughput

0.536

High

166138

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

11

High-throughput

0.536

High

166140

PRS4
26S proteasome regulatory subunit 4

1

1

High-throughput

0.536

High

166143

TFAP4
Transcription factor AP-4

1

1

High-throughput

0.536

High

166144

RING1
E3 ubiquitin-protein ligase RING1

1

4

High-throughput

0.536

High

166146

FOXC1
Forkhead box protein C1

1

1

High-throughput

0.536

High

166147

MTA1
Metastasis-associated protein MTA1

1

3

High-throughput

0.536

High

166149

HDAC1
Histone deacetylase 1

1

2

High-throughput

0.536

High

166150

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

1

High-throughput

0.536

High

166151

SAFB2
Scaffold attachment factor B2

1

11

High-throughput

0.536

High

166152

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

5

High-throughput

0.536

High

166155

MDC1
Mediator of DNA damage checkpoint protein 1

1

10

High-throughput

0.536

High

166156

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

8

High-throughput

0.536

High

166157

SAFB1
Scaffold attachment factor B1

1

12

High-throughput

0.536

High

166158

RBBP7
Histone-binding protein RBBP7

1

8

High-throughput

0.536

High

166163

HMBX1
Homeobox-containing protein 1

1

2

High-throughput

0.536

High

166168

SUGP2
SURP and G-patch domain-containing protein 2

1

2

High-throughput

0.536

High

166169

RB12B
RNA-binding protein 12B

1

10

High-throughput

0.536

High

166171

LEMD2
LEM domain-containing protein 2

1

1

High-throughput

0.536

High

166176

P66B
Transcriptional repressor p66-beta

1

1

High-throughput

0.536

High

166177

DNJC9
DnaJ homolog subfamily C member 9

1

3

High-throughput

0.536

High

166178

H1X
Histone H1.10

1

3

High-throughput

0.536

High

166181

AP2C
Transcription factor AP-2 gamma

1

2

High-throughput

0.536

High

166182

RREB1
Ras-responsive element-binding protein 1

1

1

High-throughput

0.536

High

166183

HDAC2
Histone deacetylase 2

1

2

High-throughput

0.536

High

166184

RAD50
DNA repair protein RAD50

1

5

High-throughput

0.536

High

166185

RENT1
Regulator of nonsense transcripts 1

1

10

High-throughput

0.536

High

166187

STRBP
Spermatid perinuclear RNA-binding protein

1

10

High-throughput

0.536

High

166188

DDX50
ATP-dependent RNA helicase DDX50

1

7

High-throughput

0.536

High

166190

BC11A
BCL11 transcription factor A

1

1

High-throughput

0.536

High

166193

CHM4B
Charged multivesicular body protein 4b

1

1

High-throughput

0.536

High

166195

CYBP
Calcyclin-binding protein

1

2

High-throughput

0.536

High

166197

NCOA5
Nuclear receptor coactivator 5

1

1

High-throughput

0.536

High

166198

MOV10
Helicase MOV-10

1

10

High-throughput

0.536

High

166200

SLTM
SAFB-like transcription modulator

1

11

High-throughput

0.536

High

166201

RCC2
Protein RCC2

1

3

High-throughput

0.536

High

166202

PARP2
Poly [ADP-ribose] polymerase 2

1

3

High-throughput

0.536

High

166203

TCF20
Transcription factor 20

1

3

High-throughput

0.536

High

166204

MBD1
Methyl-CpG-binding domain protein 1

1

4

High-throughput

0.536

High

166207

SATB2
DNA-binding protein SATB2

1

2

High-throughput

0.536

High

166208

ZN148
Zinc finger protein 148

1

3

High-throughput

0.536

High

166210

LAS1L
Ribosomal biogenesis protein LAS1L

1

3

High-throughput

0.536

High

166109

NPM
Nucleophosmin

1

1

High-throughput

0.515

High

166099

ZBT39
Zinc finger and BTB domain-containing protein 39

1

0

High-throughput

0.513

High

166103

BAF
Barrier-to-autointegration factor

1

0

High-throughput

0.513

High

166116

XRCC1
DNA repair protein XRCC1

1

0

High-throughput

0.513

High

166118

TFE3
Transcription factor E3

1

0

High-throughput

0.513

High

166132

EMD
Emerin

1

0

High-throughput

0.513

High

166134

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

0

High-throughput

0.513

High

166142

GTF2I
General transcription factor II-I

1

0

High-throughput

0.513

High

166145

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.513

High

166159

FSCN1
Fascin

1

0

High-throughput

0.513

High

166160

BEND3
BEN domain-containing protein 3

1

0

High-throughput

0.513

High

166166

KAISO
Transcriptional regulator Kaiso

1

0

High-throughput

0.513

High

166167

VRK3
Serine/threonine-protein kinase VRK3

1

0

High-throughput

0.513

High

166199

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.513

High

166122

CASP1
Caspase-1

1

1

Small-scale

0.494

High

166104

PRDM1
PR domain zinc finger protein 1

1

0

Small-scale

0.493

High

166098

ZN646
Zinc finger protein 646

1

1

High-throughput

0.489

High

166153

RCN2
Reticulocalbin-2

1

4

High-throughput

0.489

High

166161

H2A2A
Histone H2A type 2-A

1

2

High-throughput

0.489

High

166164

SAMD1
Sterile alpha motif domain-containing protein 1

1

3

High-throughput

0.489

High

166165

CE024
UPF0461 protein C5orf24

1

1

High-throughput

0.489

High

166172

ZBT44
Zinc finger and BTB domain-containing protein 44

1

2

High-throughput

0.489

High

166173

ZN740
Zinc finger protein 740

1

4

High-throughput

0.489

High

166174

ZN384
Zinc finger protein 384

1

1

High-throughput

0.489

High

166189

BC11B
B-cell lymphoma/leukemia 11B

1

1

High-throughput

0.489

High

166192

NKX24
Homeobox protein Nkx-2.4

1

2

High-throughput

0.489

High

166194

IKZF5
Zinc finger protein Pegasus

1

8

High-throughput

0.489

High

166209

ZN711
Zinc finger protein 711

1

2

High-throughput

0.489

High

166141

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.481

High

166180

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

1

1

High-throughput

0.481

High

166100

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

166117

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

1

Small-scale

0.479

High

166205

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

2

Small-scale

0.479

High

166196

POPD3
Popeye domain-containing protein 3

1

1

Small-scale

0.470

High

166179

APBP2
Amyloid protein-binding protein 2

1

0

High-throughput

0.460

High

166111

IRF1
Interferon regulatory factor 1

1

0

Small-scale

0.458

High

166125

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

2

High-throughput

0.445

High

166154

BECN1
Beclin-1

1

0

Small-scale

0.426

High

166139

MAZ
Myc-associated zinc finger protein

1

0

High-throughput

0.279

Low

166162

ZSC25
Zinc finger and SCAN domain-containing protein 25

1

0

High-throughput

0.279

Low

166170

ZN444
Zinc finger protein 444

1

0

High-throughput

0.279

Low

166175

THEM6
Protein THEM6

1

0

High-throughput

0.279

Low

166191

ADNP
Activity-dependent neuroprotector homeobox protein

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025