HitPredict

Interactor 1: SMAD7 (O15105)
Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (Mothers against decapentaplegic homolog 8) (MAD homolog 8) (Mothers against DPP homolog 8) (SMAD family member 7) (SMAD 7) (Smad7) (hSMAD7)
Gene: SMAD7

Interactor 2: UBP26 (Q9BXU7)
Ubiquitin carboxyl-terminal hydrolase 26 (EC 3.4.19.12) (Deubiquitinating enzyme 26) (Ubiquitin thioesterase 26) (Ubiquitin-specific-processing protease 26)
Gene: USP26

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35484112
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 426 Hs			1 913
+	Hs
		167344 SMAD7_HUMAN (1-426): 1.58e-170: 486: 100.00		UBP11_HUMAN (166-899): 2.42e-125: 404: 15.12
+	Hs
		167414 SMAD7_HUMAN (1-426): 1.58e-170: 486: 100.00		UBP15_HUMAN (186-890): 1.24e-123: 400: 14.97
+	Hs
		206947 SMAD6_HUMAN (1-425): 5.75e-147: 428: 43.56		UBP11_HUMAN (166-899): 2.42e-125: 404: 15.12
+	Hs
		206980 SMAD6_HUMAN (1-425): 5.75e-147: 428: 43.56		UBP15_HUMAN (186-890): 1.24e-123: 400: 14.97
+	Hs
		950342 SMAD3_HUMAN (81-424): 2.22e-146: 424: 26.72		UBP15_HUMAN (186-890): 1.24e-123: 400: 14.97
+	Hs
		1078786 SMAD1_HUMAN (79-424): 2.02e-145: 423: 24.26		UBP15_HUMAN (186-890): 1.24e-123: 400: 14.97
+	Hs
		1078706 SMAD2_HUMAN (82-424): 5.2e-138: 404: 24.53		UBP15_HUMAN (186-890): 1.24e-123: 400: 14.97
+	Hs
		167314 SMAD7_HUMAN (1-426): 1.58e-170: 486: 100.00		UBP2_HUMAN (571-892): 2.79e-36: 147: 11.39
+	Hs
		950242 SMAD3_HUMAN (81-424): 2.22e-146: 424: 26.72		UBP7_HUMAN (616-913): 6.94e-36: 149: 12.66
+	Hs
		271070 SMAD3_HUMAN (81-424): 2.22e-146: 424: 26.72		UBP2_HUMAN (571-892): 2.79e-36: 147: 11.39
+	Hs
		1035645 SMAD4_HUMAN (54-259): 3.55e-41: 155: 22.75		UBP15_HUMAN (186-890): 1.24e-123: 400: 14.97
+	Hs
		1078615 SMAD2_HUMAN (82-424): 5.2e-138: 404: 24.53		UBP7_HUMAN (616-913): 6.94e-36: 149: 12.66
+	Hs
		271098 SMAD2_HUMAN (82-424): 5.2e-138: 404: 24.53		UBP2_HUMAN (571-892): 2.79e-36: 147: 11.39
+	Hs
		1035532 SMAD4_HUMAN (54-259): 3.55e-41: 155: 22.75		UBP7_HUMAN (616-913): 6.94e-36: 149: 12.66
+	Hs
		1024323 SMAD4_HUMAN (54-259): 3.55e-41: 155: 22.75		UBP4_HUMAN (452-668): 2.9e-29: 127: 18.83
+	Hs
		301384 SMAD4_HUMAN (54-259): 3.55e-41: 155: 22.75		UBP19_HUMAN (478-583): 3.3e-12: 73: 25.00