Protein: MED24
Mediator of RNA polymerase II transcription subunit 24 (Activator-recruited cofactor 100 kDa component) (ARC100) (Cofactor required for Sp1 transcriptional activation subunit 4) (CRSP complex subunit 4) (Mediator complex subunit 24) (Thyroid hormone receptor-associated protein 4) (Thyroid hormone receptor-associated protein complex 100 kDa component) (Trap100) (hTRAP100) (Vitamin D3 receptor-interacting protein complex 100 kDa component) (DRIP100)

Gene: MED24
Organism: Homo sapiens
Interactions: 107
UniProt ID: O75448

Gene Ontology (top 5):
GO:0003712 - transcription coregulator activity
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0016592 - mediator complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

265376

MED16
Mediator of RNA polymerase II transcription subunit 16

3

0

Small-scale

0.803

High

265375

MED23
Mediator of RNA polymerase II transcription subunit 23

2

0

High-throughput

0.778

High

265313

CDK8
Cyclin-dependent kinase 8

15

2

Small-scale

0.762

High

265355

MED15
Mediator of RNA polymerase II transcription subunit 15

2

0

High-throughput

0.748

High

265328

MED1
Mediator of RNA polymerase II transcription subunit 1

8

1

Small-scale

0.747

High

265360

CDK19
Cyclin-dependent kinase 19

6

2

High-throughput

0.733

High

265358

MED10
Mediator of RNA polymerase II transcription subunit 10

8

0

Small-scale

0.717

High

48593

MED19
Mediator of RNA polymerase II transcription subunit 19

7

0

Small-scale

0.715

High

225318

MED14
Mediator of RNA polymerase II transcription subunit 14

5

1

Small-scale

0.714

High

265350

MED12
Mediator of RNA polymerase II transcription subunit 12

4

1

High-throughput

0.694

High

265359

MED18
Mediator of RNA polymerase II transcription subunit 18

5

0

High-throughput

0.688

High

265303

CCNC
Cyclin-C

4

1

High-throughput

0.686

High

265368

MED9
Mediator of RNA polymerase II transcription subunit 9

5

0

Small-scale

0.686

High

265361

MED28
Mediator of RNA polymerase II transcription subunit 28

5

0

High-throughput

0.684

High

265321

MED21
Mediator of RNA polymerase II transcription subunit 21

4

0

High-throughput

0.674

High

265365

MED4
Mediator of RNA polymerase II transcription subunit 4

4

0

High-throughput

0.672

High

206595

MED7
Mediator of RNA polymerase II transcription subunit 7

4

0

High-throughput

0.670

High

265364

MED20
Mediator of RNA polymerase II transcription subunit 20

4

0

High-throughput

0.670

High

265369

MED29
Mediator of RNA polymerase II transcription subunit 29

4

0

High-throughput

0.670

High

265367

MED17
Mediator of RNA polymerase II transcription subunit 17

3

1

High-throughput

0.667

High

265373

MED13
Mediator of RNA polymerase II transcription subunit 13

3

1

High-throughput

0.662

High

265341

MED25
Mediator of RNA polymerase II transcription subunit 25

4

0

Small-scale

0.661

High

265291

ESR1
Estrogen receptor

3

6

Small-scale

0.660

High

265308

SRBP1
Sterol regulatory element-binding protein 1

3

1

Small-scale

0.641

High

265347

ESR2
Estrogen receptor beta

3

5

Small-scale

0.641

High

243703

BRD4
Bromodomain-containing protein 4

3

3

Small-scale

0.640

High

265284

MED6
Mediator of RNA polymerase II transcription subunit 6

3

0

High-throughput

0.638

High

265287

MED26
Mediator of RNA polymerase II transcription subunit 26

3

0

High-throughput

0.638

High

265327

MED22
Mediator of RNA polymerase II transcription subunit 22

3

0

High-throughput

0.638

High

265335

MED27
Mediator of RNA polymerase II transcription subunit 27

3

0

High-throughput

0.638

High

265352

MED8
Mediator of RNA polymerase II transcription subunit 8

3

0

High-throughput

0.638

High

265353

MED30
Mediator of RNA polymerase II transcription subunit 30

3

0

Small-scale

0.638

High

265371

MED11
Mediator of RNA polymerase II transcription subunit 11

3

0

High-throughput

0.638

High

265377

MED31
Mediator of RNA polymerase II transcription subunit 31

3

0

High-throughput

0.638

High

265300

THA
Thyroid hormone receptor alpha

3

6

Small-scale

0.633

High

265324

NR1I3
Nuclear receptor subfamily 1 group I member 3

2

7

High-throughput

0.611

High

265340

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

2

1

High-throughput

0.611

High

265343

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

2

1

High-throughput

0.611

High

265305

RBTN2
Rhombotin-2

2

0

High-throughput

0.602

High

265299

ANDR
Androgen receptor

2

5

Small-scale

0.586

High

265301

VDR
Vitamin D3 receptor

2

6

Small-scale

0.584

High

265351

FBXW7
F-box/WD repeat-containing protein 7

2

0

Small-scale

0.559

High

265289

AACT
Alpha-1-antichymotrypsin

1

1

High-throughput

0.536

High

265330

SMAD2
Mothers against decapentaplegic homolog 2

1

5

Small-scale

0.515

High

265331

SMAD1
Mothers against decapentaplegic homolog 1

1

5

Small-scale

0.515

High

206989

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.513

High

265286

ZWINT
ZW10 interactor

1

0

High-throughput

0.513

High

265295

LDHC
L-lactate dehydrogenase C chain

1

0

High-throughput

0.513

High

265296

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.513

High

265297

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.513

High

265307

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.513

High

265311

KI67
Proliferation marker protein Ki-67

1

0

High-throughput

0.513

High

265323

IMB1
Importin subunit beta-1

1

0

High-throughput

0.513

High

265336

FXL19
F-box/LRR-repeat protein 19

1

0

High-throughput

0.513

High

265315

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.508

High

265302

RXRA
Retinoic acid receptor RXR-alpha

1

4

Small-scale

0.501

High

265309

PPARG
Peroxisome proliferator-activated receptor gamma

1

7

Small-scale

0.501

High

265310

HNF4A
Hepatocyte nuclear factor 4-alpha

1

5

Small-scale

0.501

High

265320

PPARA
Peroxisome proliferator-activated receptor alpha

1

7

Small-scale

0.501

High

265312

SPB4
Serpin B4

1

1

High-throughput

0.489

High

265374

KS6A6
Ribosomal protein S6 kinase alpha-6

1

0

High-throughput

0.486

High

265379

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

Small-scale

0.480

High

167313

SMAD7
Mothers against decapentaplegic homolog 7

1

5

Small-scale

0.479

High

171350

SMAD9
Mothers against decapentaplegic homolog 9

1

5

Small-scale

0.479

High

229257

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

1

High-throughput

0.479

High

265290

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

265304

BRD2
Bromodomain-containing protein 2

1

4

High-throughput

0.479

High

265317

SMAD3
Mothers against decapentaplegic homolog 3

1

5

Small-scale

0.479

High

265326

BRD3
Bromodomain-containing protein 3

1

4

High-throughput

0.479

High

265356

SMAD5
Mothers against decapentaplegic homolog 5

1

5

Small-scale

0.479

High

265285

UBXN7
UBX domain-containing protein 7

1

0

High-throughput

0.458

High

265294

JUN
Transcription factor Jun

1

0

High-throughput

0.458

High

265298

PARP1
Poly [ADP-ribose] polymerase 1

1

0

Small-scale

0.458

High

265306

PML
Protein PML

1

0

High-throughput

0.458

High

265318

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

265319

TOP2B
DNA topoisomerase 2-beta

1

0

High-throughput

0.458

High

265322

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

0

Small-scale

0.458

High

265329

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

265332

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

0

High-throughput

0.458

High

265339

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

265344

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

0

High-throughput

0.458

High

265354

QKI
KH domain-containing RNA-binding protein QKI

1

0

High-throughput

0.458

High

265357

EPAS1
Endothelial PAS domain-containing protein 1

1

0

Small-scale

0.458

High

265363

STN1
CST complex subunit STN1

1

0

High-throughput

0.458

High

265370

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

73023

B4DUB1
cDNA FLJ50029, highly similar to Cell division cycle 2-like protein kinase 6

1

2

High-throughput

0.445

High

91294

E5RFK5
Cyclin-C

1

1

High-throughput

0.445

High

265348

KAT2A
Histone acetyltransferase KAT2A

1

4

Small-scale

0.445

High

265316

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.437

High

265333

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.437

High

265292

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.426

High

265378

TRRAP
Transformation/transcription domain-associated protein

1

0

Small-scale

0.426

High

265314

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

265288

TCL1B
T-cell leukemia/lymphoma protein 1B

3

0

High-throughput

0.347

High

265325

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.279

Low

265342

B3GN8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8

1

0

High-throughput

0.279

Low

265345

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.279

Low

265346

PP4R1
Serine/threonine-protein phosphatase 4 regulatory subunit 1

1

0

High-throughput

0.279

Low

265349

KIFA3
Kinesin-associated protein 3

1

0

High-throughput

0.279

Low

265372

SUCO
SUN domain-containing ossification factor

1

0

High-throughput

0.279

Low

155672

TNF11
Tumor necrosis factor ligand superfamily member 11

1

0

High-throughput

0.265

Low

265293

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.261

Low

265334

CARL2
Capping protein, Arp2/3 and myosin-I linker protein 2

1

0

High-throughput

0.249

Low

265337

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

265338

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

265362

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

265366

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024