Protein: OSBP1
Oxysterol-binding protein 1

Gene: OSBP1, OSBP
Organism: Homo sapiens
Interactions: 84
UniProt ID: P22059

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0005737 - cytoplasm
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

643395

PKHA3
Pleckstrin homology domain-containing family A member 3

2

15

High-throughput

0.811

High

643385

OSBP2
Oxysterol-binding protein 2

2

13

High-throughput

0.789

High

643401

VAPA
Vesicle-associated membrane protein-associated protein A

11

20

Small-scale

0.758

High

332867

VAPB
Vesicle-associated membrane protein-associated protein B/C

7

20

Small-scale

0.745

High

643355

CSK21
Casein kinase II subunit alpha

1

5

High-throughput

0.710

High

276669

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

4

4

High-throughput

0.702

High

643388

PKHA8
Pleckstrin homology domain-containing family A member 8

1

14

High-throughput

0.691

High

643368

BTNL8
Butyrophilin-like protein 8

3

2

High-throughput

0.667

High

643370

BT2A1
Butyrophilin subfamily 2 member A1

3

2

High-throughput

0.667

High

643387

LRC46
Leucine-rich repeat-containing protein 46

4

2

High-throughput

0.630

High

643347

CADH5
Cadherin-5

2

2

High-throughput

0.628

High

643382

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

3

High-throughput

0.628

High

643396

PCDBG
Protocadherin beta-16

2

4

High-throughput

0.628

High

643408

PCDG5
Protocadherin gamma-A5

2

4

High-throughput

0.628

High

362765

EGFR
Epidermal growth factor receptor

1

11

High-throughput

0.618

High

411349

NTRK1
High affinity nerve growth factor receptor

1

17

High-throughput

0.618

High

643362

NTRK3
NT-3 growth factor receptor

1

17

High-throughput

0.618

High

643375

RHG24
Rho GTPase-activating protein 24

1

3

High-throughput

0.618

High

643390

MEP50
Methylosome protein WDR77

1

4

High-throughput

0.618

High

643394

PKHA4
Pleckstrin homology domain-containing family A member 4

1

14

High-throughput

0.618

High

643398

SAC1
Phosphatidylinositol-3-phosphatase SAC1

2

3

Small-scale

0.611

High

424483

PAI2
Plasminogen activator inhibitor 2

2

0

High-throughput

0.602

High

240748

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

142279

PEX7
Peroxisomal targeting signal 2 receptor

1

1

High-throughput

0.575

High

643365

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.575

High

643373

LRRT1
Leucine-rich repeat transmembrane neuronal protein 1

2

1

High-throughput

0.574

High

48525

ESYT2
Extended synaptotagmin-2

1

6

High-throughput

0.536

High

129993

PGRC1
Membrane-associated progesterone receptor component 1

1

1

High-throughput

0.536

High

643351

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.536

High

643352

BAP31
B-cell receptor-associated protein 31

1

1

High-throughput

0.536

High

643360

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

2

High-throughput

0.536

High

643364

TTMP
TPA-induced transmembrane protein

1

1

High-throughput

0.536

High

643376

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.536

High

643378

AT11C
Phospholipid-transporting ATPase IG

1

2

High-throughput

0.536

High

643386

I17RA
Interleukin-17 receptor A

1

1

High-throughput

0.536

High

643389

SPAG5
Sperm-associated antigen 5

1

2

High-throughput

0.536

High

643391

ESYT1
Extended synaptotagmin-1

1

5

High-throughput

0.536

High

643406

PCDB3
Protocadherin beta-3

1

4

High-throughput

0.536

High

643407

PCDGL
Protocadherin gamma-C4

1

4

High-throughput

0.536

High

643409

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

4

High-throughput

0.536

High

643354

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

1

High-throughput

0.515

High

643359

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.513

High

643363

TM52B
Transmembrane protein 52B

1

0

High-throughput

0.513

High

643366

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

0

High-throughput

0.513

High

643367

K2C80
Keratin, type II cytoskeletal 80

1

0

High-throughput

0.513

High

643377

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.513

High

643381

CC107
Coiled-coil domain-containing protein 107

1

0

High-throughput

0.513

High

643403

TM63C
Osmosensitive cation channel TMEM63C

1

0

High-throughput

0.513

High

643383

ALG3
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

1

1

Small-scale

0.506

High

643361

NPTX1
Neuronal pentraxin-1

1

1

High-throughput

0.489

High

643353

SNP25
Synaptosomal-associated protein 25

1

7

Small-scale

0.481

High

403822

GCR
Glucocorticoid receptor

1

3

High-throughput

0.479

High

413185

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

464809

SP1
Transcription factor Sp1

1

1

High-throughput

0.479

High

475893

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

2

High-throughput

0.479

High

587912

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

643346

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

643348

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

643349

SRBP1
Sterol regulatory element-binding protein 1

1

1

Small-scale

0.479

High

643350

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

643356

EP300
Histone acetyltransferase p300

1

3

High-throughput

0.479

High

643357

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

1

Small-scale

0.479

High

643358

SRBP2
Sterol regulatory element-binding protein 2

1

3

Small-scale

0.479

High

643369

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.479

High

643372

TM11B
Transmembrane protease serine 11B

1

4

High-throughput

0.479

High

643379

RN149
E3 ubiquitin-protein ligase RNF149

1

4

High-throughput

0.479

High

643380

MSPD2
Motile sperm domain-containing protein 2

1

16

High-throughput

0.479

High

643384

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.479

High

643393

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

12

Small-scale

0.479

High

643397

TMPS4
Transmembrane protease serine 4

1

4

High-throughput

0.479

High

643400

OTULL
Inactive ubiquitin thioesterase OTULINL

1

7

High-throughput

0.479

High

643402

TM216
Transmembrane protein 216

1

2

High-throughput

0.479

High

643404

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

643405

XPO7
Exportin-7

1

2

High-throughput

0.479

High

238385

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.458

High

637085

VATC1
V-type proton ATPase subunit C 1

1

0

High-throughput

0.458

High

330041

VENTX
Homeobox protein VENTX

1

3

High-throughput

0.445

High

643392

LNP
Endoplasmic reticulum junction formation protein lunapark

1

2

High-throughput

0.445

High

105338

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

643371

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

643374

TMM17
Transmembrane protein 17

1

2

High-throughput

0.437

High

369157

OAS1
2'-5'-oligoadenylate synthase 1

1

0

High-throughput

0.426

High

643399

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

643345

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025