HitPredict

Interactor 1: IKKA (O15111)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
Gene: CHUK

Interactor 2: PP2AA (P67775)
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C)
Gene: PPP2CA

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	36736316, 16126728
Identification Methods	affinity chromatography technology, molecular sieving
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0046982 - protein heterodimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 745 Hs			1 309
+	Hs
		167511 IKKA_HUMAN (1-745): 0: 588: 100.00		PP2AB_HUMAN (1-309): 0: 528: 97.41
+	Hs
		158442 IKKB_HUMAN (1-743): 0: 583: 50.87		PP2AA_HUMAN (1-309): 0: 529: 100.00
+	Hs
		167506 IKKA_HUMAN (1-745): 0: 588: 100.00		PP4C_HUMAN (4-309): 0: 508: 64.82
+	Hs
		167510 IKKA_HUMAN (1-745): 0: 588: 100.00		PP1A_HUMAN (5-296): 0: 504: 46.51
+	Hs
		158435 IKKB_HUMAN (1-743): 0: 583: 50.87		PP4C_HUMAN (4-309): 0: 508: 64.82
+	Mm
		291448 IKKB_MOUSE (1-743): 0: 584: 49.13		PP1A_MOUSE (5-296): 0: 504: 46.84
+	Hs
		158438 IKKB_HUMAN (1-743): 0: 583: 50.87		PP1A_HUMAN (5-296): 0: 504: 46.51
+	Hs
		930991 SIK2_HUMAN (7-731): 2.17e-125: 398: 15.52		PP2AA_HUMAN (1-309): 0: 529: 100.00
+	Hs
		915188 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		PP2AB_HUMAN (1-309): 0: 528: 97.41
+	Mm
		956533 TBK1_MOUSE (15-726): 8e-127: 396: 18.68		PP4C_MOUSE (4-309): 0: 508: 64.82
+	Hs
		738035 SIK2_HUMAN (7-731): 2.17e-125: 398: 15.52		PP1G_HUMAN (7-306): 0: 505: 45.96
+	Hs
		906123 SIK2_HUMAN (7-731): 2.17e-125: 398: 15.52		PP1A_HUMAN (5-296): 0: 504: 46.51
+	Hs
		625340 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		PP2AA_HUMAN (1-309): 0: 529: 100.00
+	Hs
		890962 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		PP4C_HUMAN (4-309): 0: 508: 64.82
+	Hs
		931029 KS6B2_HUMAN (15-419): 1.39e-115: 359: 21.24		PP2AA_HUMAN (1-309): 0: 529: 100.00
+	Hs
		625180 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		PP1G_HUMAN (7-306): 0: 505: 45.96
+	Hs
		625299 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		PP1A_HUMAN (5-296): 0: 504: 46.51
+	Dm
		619883 AKT1_DROME (3-371): 1.03e-88: 293: 22.58		PP2A_DROME (1-309): 0: 524: 93.85
+	Hs
		930841 KCC1A_HUMAN (15-298): 9.69e-89: 285: 26.06		PP2AA_HUMAN (1-309): 0: 529: 100.00
+	Hs
		610705 KAPCB_HUMAN (5-316): 3.65e-89: 285: 26.96		PP1A_HUMAN (5-296): 0: 504: 46.51