Interactor 1: IKKA (O15111)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
Gene: CHUK

Interactor 2: FADD (Q13158)
FAS-associated death domain protein (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity)
Gene: FADD

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.47 1.00 0.691

The method score is based on:

Property Details
Experiments 30561431
Identification Methods affinity chromatography technology, virotrap
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains DED~Pkinase
Common GO terms GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0009898 - cytoplasmic side of plasma membrane
GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
GO:0044877 - protein-containing complex binding
and 2 others

more...

Homologous interactions 9

Homologous interactions

Color coding for hit scores

1 745
Hs

1 208
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024