HitPredict

Interactor 1: IKKA (O15111)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
Gene: CHUK

Interactor 2: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.900

Property	Details
Experiments	33961781, 35271311, 25036637, 14743216
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FKBP_C~Pkinase
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 745 Hs			1 457
+	Hs
		158464 IKKB_HUMAN (1-743): 0: 583: 50.87		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		158449 IKKB_HUMAN (1-743): 0: 583: 50.87		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		1034848 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		1035034 KS6B2_HUMAN (15-419): 1.39e-115: 359: 21.24		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		625378 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		568651 KAPCA_HUMAN (3-316): 7.79e-90: 287: 27.41		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		610723 KAPCB_HUMAN (5-316): 3.65e-89: 285: 26.96		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		272862 KS6A4_HUMAN (1-402): 3.2e-70: 247: 19.07		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		684793 Q59GT1_HUMAN (1-702): 0: 550: 100.00		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		1034968 MARK4_HUMAN (13-224): 1.59e-24: 111: 34.56		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		1012427 M3K5_HUMAN (14-745): 1.84e-130: 421: 18.34		Q0VDC6_HUMAN (151-247): 5.97e-21: 90.6: 26.73
+	Hs
		684792 Q59GL9_HUMAN (67-512): 1.14e-131: 400: 56.98		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		685087 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		684710 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		1053243 KS6B2_HUMAN (15-419): 1.39e-115: 359: 21.24		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Hs
		568664 KAPCA_HUMAN (3-316): 7.79e-90: 287: 27.41		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Dm
		1179500 Q8MQJ7_DROME (15-221): 1.8e-26: 117: 33.18		Q7K3D4_DROME (3-148): 5.36e-22: 99.5: 23.31