Protein: PTN13
Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1)

Gene: PTN13, PTPN13
Organism: Homo sapiens
Interactions: 187
UniProt ID: Q12923

Gene Ontology (top 5):
GO:0001933 - negative regulation of protein phosphorylation
GO:0004725 - protein tyrosine phosphatase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1090163

RPGF6
Rap guanine nucleotide exchange factor 6

2

9

Small-scale

0.799

High

895865

PDLI4
PDZ and LIM domain protein 4

1

20

Small-scale

0.756

High

710205

EPHA2
Ephrin type-A receptor 2

2

20

High-throughput

0.754

High

977965

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

249128

DSCAM
Cell adhesion molecule DSCAM

1

16

High-throughput

0.698

High

1090150

STXB4
Syntaxin-binding protein 4

1

20

High-throughput

0.691

High

683447

IKBA
NF-kappa-B inhibitor alpha

4

20

Small-scale

0.680

High

675012

TNR6
Tumor necrosis factor receptor superfamily member 6

4

12

Small-scale

0.676

High

1049242

1433F
14-3-3 protein eta

3

20

High-throughput

0.667

High

1090130

TRIP6
Thyroid receptor-interacting protein 6

2

19

Small-scale

0.649

High

533846

GHR
Growth hormone receptor

1

20

Small-scale

0.647

High

1090185

PKHA1
Pleckstrin homology domain-containing family A member 1

2

12

Small-scale

0.646

High

729788

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.635

High

966254

1433G
14-3-3 protein gamma

2

20

High-throughput

0.635

High

971460

1433E
14-3-3 protein epsilon

2

6

High-throughput

0.635

High

990160

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.635

High

126570

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

208661

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

6

High-throughput

0.618

High

245224

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

8

High-throughput

0.618

High

341039

DIRA3
GTP-binding protein Di-Ras3

1

16

High-throughput

0.618

High

363203

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.618

High

375462

RASK
GTPase KRas

1

20

High-throughput

0.618

High

411834

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

440050

LCK
Tyrosine-protein kinase Lck

1

20

High-throughput

0.618

High

463486

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.618

High

463949

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

High-throughput

0.618

High

466227

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

541457

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.618

High

601259

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

614684

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

18

High-throughput

0.618

High

640158

EPHA1
Ephrin type-A receptor 1

1

20

High-throughput

0.618

High

710622

EPHA3
Ephrin type-A receptor 3

1

20

High-throughput

0.618

High

710820

EPHB2
Ephrin type-B receptor 2

1

20

High-throughput

0.618

High

711881

LTK
Leukocyte tyrosine kinase receptor

1

20

High-throughput

0.618

High

901212

RAB7A
Ras-related protein Rab-7a

1

15

High-throughput

0.618

High

910030

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

931840

EPHA5
Ephrin type-A receptor 5

1

20

High-throughput

0.618

High

932061

EPHA4
Ephrin type-A receptor 4

1

20

High-throughput

0.618

High

936313

AFAD
Afadin

1

20

High-throughput

0.618

High

953414

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

955103

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

961996

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

962724

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.618

High

988322

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1090128

RAB35
Ras-related protein Rab-35

1

19

High-throughput

0.618

High

1090129

EPHA7
Ephrin type-A receptor 7

1

20

High-throughput

0.618

High

1090131

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

1090132

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.618

High

1090134

NTRK2
BDNF/NT-3 growth factors receptor

1

20

High-throughput

0.618

High

1090142

SPD2A
SH3 and PX domain-containing protein 2A

1

8

High-throughput

0.618

High

1090146

STYK1
Tyrosine-protein kinase STYK1

1

20

High-throughput

0.618

High

1090152

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

1090157

KSR1
Kinase suppressor of Ras 1

1

20

High-throughput

0.618

High

1090164

PARD3
Partitioning defective 3 homolog

1

20

High-throughput

0.618

High

1090165

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.618

High

1090181

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1090186

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1090188

E41LA
Band 4.1-like protein 4A

1

19

High-throughput

0.618

High

1090196

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

12

High-throughput

0.618

High

1090204

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.618

High

1090208

RPGF2
Rap guanine nucleotide exchange factor 2

1

9

High-throughput

0.618

High

303040

DFFB
DNA fragmentation factor subunit beta

2

0

High-throughput

0.602

High

833408

RGS2
Regulator of G-protein signaling 2

2

0

High-throughput

0.602

High

1090133

PKN2
Serine/threonine-protein kinase N2

1

13

Small-scale

0.592

High

349056

LATS1
Serine/threonine-protein kinase LATS1

2

13

High-throughput

0.584

High

540425

LAMP1
Lysosome-associated membrane glycoprotein 1

2

15

High-throughput

0.584

High

951646

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

2

7

Small-scale

0.584

High

1090147

LRFN4
Leucine-rich repeat and fibronectin type-III domain-containing protein 4

1

10

Small-scale

0.575

High

396007

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

690956

1433T
14-3-3 protein theta

1

20

High-throughput

0.554

High

1090178

PDC10
Programmed cell death protein 10

1

0

Small-scale

0.551

High

74474

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

2

High-throughput

0.536

High

930865

HSP72
Heat shock-related 70 kDa protein 2

1

6

High-throughput

0.536

High

1090127

RPGF1
Rap guanine nucleotide exchange factor 1

1

9

High-throughput

0.536

High

1090149

TRI72
Tripartite motif-containing protein 72

1

5

High-throughput

0.536

High

1090169

ARRD3
Arrestin domain-containing protein 3

1

7

High-throughput

0.536

High

1090183

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.536

High

1090197

STK26
Serine/threonine-protein kinase 26

1

16

High-throughput

0.536

High

1090210

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

6

High-throughput

0.536

High

1090184

PKHA2
Pleckstrin homology domain-containing family A member 2

1

10

Small-scale

0.527

High

1090191

LATS2
Serine/threonine-protein kinase LATS2

1

15

High-throughput

0.515

High

1090141

EFMT2
EEF1A lysine methyltransferase 2

1

0

High-throughput

0.513

High

869729

MTR1A
Melatonin receptor type 1A

1

8

High-throughput

0.508

High

668572

APC
Adenomatous polyposis coli protein

1

13

Small-scale

0.501

High

762200

CRFR1
Corticotropin-releasing factor receptor 1

1

3

Small-scale

0.501

High

764705

CTNB1
Catenin beta-1

1

20

Small-scale

0.501

High

869479

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

2

Small-scale

0.501

High

1022843

EFNB1
Ephrin-B1

1

3

Small-scale

0.501

High

1090140

RHG29
Rho GTPase-activating protein 29

1

9

Small-scale

0.501

High

344405

TBCD8
TBC1 domain family member 8

1

1

High-throughput

0.489

High

706114

S10A2
Protein S100-A2

1

4

High-throughput

0.489

High

1090160

ZCH10
Zinc finger CCHC domain-containing protein 10

1

5

High-throughput

0.489

High

1090175

TCPQM
T-complex protein 1 subunit theta-like 2

1

5

High-throughput

0.489

High

226013

STX6
Syntaxin-6

1

4

High-throughput

0.479

High

246565

KDM1A
Lysine-specific histone demethylase 1A

1

3

High-throughput

0.479

High

252054

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.479

High

259872

BRD4
Bromodomain-containing protein 4

1

8

High-throughput

0.479

High

269546

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

10

High-throughput

0.479

High

299170

FLOT1
Flotillin-1

1

14

High-throughput

0.479

High

327242

ZFPL1
Zinc finger protein-like 1

1

6

High-throughput

0.479

High

345732

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

7

High-throughput

0.479

High

355508

NSD2
Histone-lysine N-methyltransferase NSD2

1

2

Small-scale

0.479

High

400740

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

High-throughput

0.479

High

487248

PARP1
Poly [ADP-ribose] polymerase 1

1

7

High-throughput

0.479

High

588570

RFA2
Replication protein A 32 kDa subunit

1

9

High-throughput

0.479

High

603954

CXA1
Gap junction alpha-1 protein

1

15

High-throughput

0.479

High

613011

EGR1
Early growth response protein 1

1

7

High-throughput

0.479

High

637890

NF1
Neurofibromin

1

9

High-throughput

0.479

High

642833

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

10

High-throughput

0.479

High

692052

MARK3
MAP/microtubule affinity-regulating kinase 3

1

5

Small-scale

0.479

High

695326

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

High-throughput

0.479

High

715563

MARCS
Myristoylated alanine-rich C-kinase substrate

1

10

High-throughput

0.479

High

730551

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

764319

CTNA1
Catenin alpha-1

1

2

Small-scale

0.479

High

768066

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

830643

CCNF
Cyclin-F

1

7

High-throughput

0.479

High

839752

EPS15
Epidermal growth factor receptor substrate 15

1

16

Small-scale

0.479

High

845619

MUC18
Cell surface glycoprotein MUC18

1

20

High-throughput

0.479

High

862083

YAP1
Transcriptional coactivator YAP1

1

20

High-throughput

0.479

High

891141

GSK3A
Glycogen synthase kinase-3 alpha

1

4

High-throughput

0.479

High

891500

GSK3B
Glycogen synthase kinase-3 beta

1

12

High-throughput

0.479

High

904656

MECP2
Methyl-CpG-binding protein 2

1

2

High-throughput

0.479

High

984090

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

4

High-throughput

0.479

High

1004044

CXAR
Coxsackievirus and adenovirus receptor

1

16

High-throughput

0.479

High

1037786

IRF8
Interferon regulatory factor 8

1

4

Small-scale

0.479

High

1041030

CAV1
Caveolin-1

1

12

High-throughput

0.479

High

1045231

TF65
Transcription factor p65

1

9

High-throughput

0.479

High

1090123

SQSTM
Sequestosome-1

1

4

Small-scale

0.479

High

1090125

HDAC1
Histone deacetylase 1

1

9

High-throughput

0.479

High

1090126

CUL3
Cullin-3

1

7

High-throughput

0.479

High

1090135

OCLN
Occludin

1

9

High-throughput

0.479

High

1090138

AMOT
Angiomotin

1

20

High-throughput

0.479

High

1090139

MIDN
Midnolin

1

4

High-throughput

0.479

High

1090143

DEN4C
DENN domain-containing protein 4C

1

6

High-throughput

0.479

High

1090145

RNF43
E3 ubiquitin-protein ligase RNF43

1

20

High-throughput

0.479

High

1090153

NAA40
N-alpha-acetyltransferase 40

1

4

High-throughput

0.479

High

1090155

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

9

High-throughput

0.479

High

1090156

MIB1
E3 ubiquitin-protein ligase MIB1

1

15

High-throughput

0.479

High

1090158

CXD3
Gap junction delta-3 protein

1

15

High-throughput

0.479

High

1090159

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.479

High

1090166

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1090168

CK052
Uncharacterized protein C11orf52

1

8

High-throughput

0.479

High

1090170

PF21A
PHD finger protein 21A

1

5

High-throughput

0.479

High

1090179

WWTR1
WW domain-containing transcription regulator protein 1

1

20

High-throughput

0.479

High

1090180

DNJC5
DnaJ homolog subfamily C member 5

1

11

High-throughput

0.479

High

1090182

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

1090189

KI13B
Kinesin-like protein KIF13B

1

10

High-throughput

0.479

High

1090192

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

4

High-throughput

0.479

High

1090194

ARL8B
ADP-ribosylation factor-like protein 8B

1

16

High-throughput

0.479

High

1090195

ARL15
ADP-ribosylation factor-like protein 15

1

20

High-throughput

0.479

High

1090198

CING
Cingulin

1

6

High-throughput

0.479

High

1090199

FBW1B
F-box/WD repeat-containing protein 11

1

5

High-throughput

0.479

High

1090200

FBXL2
F-box/LRR-repeat protein 2

1

1

Small-scale

0.479

High

1090201

RCOR1
REST corepressor 1

1

2

High-throughput

0.479

High

1090202

ZBT21
Zinc finger and BTB domain-containing protein 21

1

1

High-throughput

0.479

High

1090203

PPM1H
Protein phosphatase 1H

1

2

High-throughput

0.479

High

1090206

GIT1
ARF GTPase-activating protein GIT1

1

11

Small-scale

0.479

High

1090207

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.479

High

1090209

KCTD3
BTB/POZ domain-containing protein KCTD3

1

13

High-throughput

0.479

High

719319

MPIP3
M-phase inducer phosphatase 3

1

0

High-throughput

0.458

High

1090176

LPIN3
Phosphatidate phosphatase LPIN3

1

0

High-throughput

0.458

High

1090211

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

0

Small-scale

0.458

High

138826

STK25
Serine/threonine-protein kinase 25

1

9

Small-scale

0.445

High

190217

MOT4
Monocarboxylate transporter 4

1

8

High-throughput

0.445

High

1090124

TBB3
Tubulin beta-3 chain

1

6

High-throughput

0.445

High

1090151

TBA1A
Tubulin alpha-1A chain

1

4

High-throughput

0.445

High

1090193

RN146
E3 ubiquitin-protein ligase RNF146

1

1

Small-scale

0.445

High

1090190

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

139859

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

3

High-throughput

0.437

High

281314

GGYF1
GRB10-interacting GYF protein 1

1

5

High-throughput

0.437

High

1090137

AR13B
ADP-ribosylation factor-like protein 13B

1

18

High-throughput

0.437

High

1090144

A16L1
Autophagy-related protein 16-1

1

10

High-throughput

0.437

High

1090148

GGYF2
GRB10-interacting GYF protein 2

1

18

High-throughput

0.437

High

1090154

TMM17
Transmembrane protein 17

1

4

High-throughput

0.437

High

1090161

DEN1A
DENN domain-containing protein 1A

1

8

High-throughput

0.437

High

1090162

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

20

High-throughput

0.437

High

1090167

GOGA1
Golgin subfamily A member 1

1

6

High-throughput

0.437

High

1090174

FMNL2
Formin-like protein 2

1

6

High-throughput

0.437

High

1090177

RTKN
Rhotekin

1

1

High-throughput

0.437

High

1090187

TANC2
Protein TANC2

1

10

High-throughput

0.437

High

1090205

NINL
Ninein-like protein

1

6

High-throughput

0.437

High

231563

PRKY
Putative serine/threonine-protein kinase PRKY

1

9

High-throughput

0.407

High

1090171

ENTR1
Endosome-associated-trafficking regulator 1

2

0

Small-scale

0.305

High

66494

RASFA
Ras association domain-containing protein 10

1

0

High-throughput

0.279

Low

1090136

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

1090172

MR1L1
MORF4 family-associated protein 1-like 1

1

0

High-throughput

0.279

Low

1090173

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025