HitPredict

Interactor 1: FYB1 (O15117)
FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein)
Gene: FYB1

Interactor 2: CRKL (P46109)
Crk-like protein
Gene: CRKL

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	22074159
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	SH2~SH3_2, SH3_1~SH3_2, SH3_2~SH3_2
Common GO terms	GO:0005829 - cytosol GO:0032991 - protein-containing complex GO:0050852 - T cell receptor signaling pathway
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 783 Hs			1 303
+	Hs
		167747 FYB1_HUMAN (1-783): 3.31e-92: 308: 100.00		CRK_HUMAN (3-302): 8.95e-54: 179: 55.21
+	Hs
		167733 FYB1_HUMAN (1-783): 3.31e-92: 308: 100.00		GRAP2_HUMAN (4-291): 5.79e-36: 133: 14.97
+	Hs
		167742 FYB1_HUMAN (1-783): 3.31e-92: 308: 100.00		PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80
+	Hs
		167740 FYB1_HUMAN (1-783): 3.31e-92: 308: 100.00		NCK1_HUMAN (85-196): 4.12e-16: 79.8: 22.81
+	Mm
		193087 FYB1_MOUSE (1-783): 7.99e-67: 239: 70.52		GRAP2_MOUSE (4-291): 5.63e-37: 136: 15.25
+	Hs
		167751 FYB1_HUMAN (1-783): 3.31e-92: 308: 100.00		GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32
+	Hs
		167730 FYB1_HUMAN (1-783): 3.31e-92: 308: 100.00		NCK2_HUMAN (72-204): 1.51e-09: 60.1: 21.48
+	Ce
		136804 UNC89_CAEEL (14-669): 4.99e-25: 114: 11.94		VAV_CAEEL (14-185): 2.45e-26: 111: 21.91
+	Hs
		855816 TITIN_HUMAN (311-745): 7.86e-09: 61.9: 12.22		VAV2_HUMAN (14-180): 4.46e-40: 150: 19.80
+	Hs
		1186102 MICA3_HUMAN (14-697): 1.07e-26: 119: 10.91		CD2AP_HUMAN (242-303): 7.78e-13: 70.5: 28.57
+	Hs
		554292 MUC1_HUMAN (6-732): 3.39e-28: 124: 9.80		GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32
+	Hs
		1056926 MDC1_HUMAN (16-730): 7.54e-15: 81.2: 9.50		SH3K1_HUMAN (219-297): 1.64e-15: 78.7: 24.69
+	Hs
		924760 PRG4_HUMAN (243-720): 1.33e-15: 83.5: 9.28		GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32
+	Hs
		203208 SYNJ1_HUMAN (264-675): 3.42e-09: 62.7: 8.65		NCK1_HUMAN (85-196): 4.12e-16: 79.8: 22.81
+	Hs
		203241 SYNJ1_HUMAN (264-675): 3.42e-09: 62.7: 8.65		SH3K1_HUMAN (219-297): 1.64e-15: 78.7: 24.69
+	Hs
		517796 NFH_HUMAN (18-409): 7.32e-12: 71.5: 14.54		GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32
+	Hs
		203218 SYNJ1_HUMAN (264-675): 3.42e-09: 62.7: 8.65		GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32