HitPredict

Interactor 1: ARC1B (O15143)
Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC)
Gene: ARPC1B

Interactor 2: ARP3B (Q9P1U1)
Actin-related protein 3B (ARP3-beta) (Actin-like protein 3B) (Actin-related protein ARP4)
Gene: ACTR3B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.947

Property	Details
Experiments	26186194, 28514442, 24981860, 33961781, 17353931, 29568061
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~WD40
Common GO terms	GO:0051015 - actin filament binding GO:0070062 - extracellular exosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 372 Hs			1 418
+	Dm
		332991 O97182_DROME (9-371): 4.38e-102: 308: 50.00		ARP3_DROME (1-418): 0: 557: 79.67
+	Hs
		1270214 ARC1A_HUMAN (1-371): 6.17e-84: 261: 67.83		ARP3B_HUMAN (1-418): 0: 590: 100.00
+	Hs
		896797 ARC1A_HUMAN (1-371): 6.17e-84: 261: 67.83		ARP3_HUMAN (1-418): 0: 571: 90.67
+	Dm
		332994 O97182_DROME (9-371): 4.38e-102: 308: 50.00		ACT3_DROME (3-414): 0: 520: 35.11
+	Hs
		168763 ARC1B_HUMAN (9-372): 1.2e-79: 250: 100.00		ARP3_HUMAN (1-418): 0: 571: 90.67
+	Hs
		891938 ARC1A_HUMAN (1-371): 6.17e-84: 261: 67.83		ACTB_HUMAN (1-414): 0: 528: 35.42
+	Hs
		168762 ARC1B_HUMAN (9-372): 1.2e-79: 250: 100.00		ACTB_HUMAN (1-414): 0: 528: 35.42
+	Hs
		168775 ARC1B_HUMAN (9-372): 1.2e-79: 250: 100.00		ACTG_HUMAN (1-414): 0: 528: 35.18
+	Sp
		689650 ARPC1_SCHPO (7-359): 3.76e-89: 274: 41.82		ARP3_SCHPO (1-415): 2.64e-175: 498: 58.70
+	Hs
		792947 LIS1_HUMAN (1-232): 1.28e-57: 194: 13.49		ACTB_HUMAN (1-414): 0: 528: 35.42
+	Hs
		792968 LIS1_HUMAN (1-232): 1.28e-57: 194: 13.49		ACTG_HUMAN (1-414): 0: 528: 35.18
+	Hs
		891660 WDR5_HUMAN (173-369): 3.45e-49: 170: 16.08		ACTB_HUMAN (1-414): 0: 528: 35.42
+	Hs
		903110 WDR5_HUMAN (173-369): 3.45e-49: 170: 16.08		ACTG_HUMAN (1-414): 0: 528: 35.18
+	Hs
		932318 SNR40_HUMAN (129-370): 1.58e-49: 171: 14.52		ACTC_HUMAN (3-414): 0: 518: 35.84
+	Sc
		863622 COPA_YEAST (1-182): 2.1e-33: 133: 11.43		ACT_YEAST (1-414): 0: 521: 34.46
+	Sc
		748545 ARPC1_YEAST (96-366): 5.97e-09: 59.3: 9.82		ARP3_YEAST (6-417): 2.6e-173: 493: 57.46