Protein: PLD2
Phospholipase D2 (PLD 2) (hPLD2) (EC 3.1.4.4) (Choline phosphatase 2) (PLD1C) (Phosphatidylcholine-hydrolyzing phospholipase D2)

Gene: PLD2
Organism: Homo sapiens
Interactions: 141
UniProt ID: O14939

Gene Ontology (top 5):
GO:0002031 - G protein-coupled receptor internalization
GO:0004630 - phospholipase D activity
GO:0005789 - endoplasmic reticulum membrane
GO:0005886 - plasma membrane
GO:0006654 - phosphatidic acid biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

168815

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

2

Small-scale

0.724

High

168821

CADH5
Cadherin-5

3

2

Small-scale

0.667

High

168874

GP156
Probable G-protein coupled receptor 156

3

1

High-throughput

0.662

High

168878

HAVR2
Hepatitis A virus cellular receptor 2

3

0

High-throughput

0.634

High

168886

CK5P3
CDK5 regulatory subunit-associated protein 3

3

0

High-throughput

0.634

High

168893

DNJC7
DnaJ homolog subfamily C member 7

4

6

High-throughput

0.630

High

168816

ACM3
Muscarinic acetylcholine receptor M3

2

2

High-throughput

0.628

High

168833

CADH8
Cadherin-8

2

2

High-throughput

0.628

High

168903

TNR19
Tumor necrosis factor receptor superfamily member 19

2

1

High-throughput

0.628

High

168866

SKAP1
Src kinase-associated phosphoprotein 1

1

1

High-throughput

0.618

High

168917

TX264
Testis-expressed protein 264

2

1

High-throughput

0.611

High

168805

TBB5
Tubulin beta chain

3

2

High-throughput

0.604

High

168912

CCG5
Voltage-dependent calcium channel gamma-5 subunit

3

2

High-throughput

0.604

High

168842

ARF1
ADP-ribosylation factor 1

2

2

Small-scale

0.602

High

168780

GP182
G-protein coupled receptor 182

2

5

High-throughput

0.601

High

168835

CXCR4
C-X-C chemokine receptor type 4

2

3

High-throughput

0.601

High

168787

DNJA2
DnaJ homolog subfamily A member 2

3

7

High-throughput

0.593

High

168838

GRB2
Growth factor receptor-bound protein 2

2

4

Small-scale

0.591

High

168813

RAC2
Ras-related C3 botulinum toxin substrate 2

1

4

Small-scale

0.589

High

168809

SRC
Proto-oncogene tyrosine-protein kinase Src

1

3

Small-scale

0.578

High

168801

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

2

Small-scale

0.561

High

168818

COF1
Cofilin-1

1

1

Small-scale

0.561

High

168824

VHL
von Hippel-Lindau disease tumor suppressor

1

1

Small-scale

0.561

High

168829

AMPH
Amphiphysin

1

3

Small-scale

0.561

High

168845

KPCD
Protein kinase C delta type

1

2

Small-scale

0.561

High

168841

TBB4B
Tubulin beta-4B chain

2

2

High-throughput

0.558

High

168914

CHIP
E3 ubiquitin-protein ligase CHIP

2

3

High-throughput

0.558

High

168902

ANLN
Anillin

1

1

High-throughput

0.553

High

168799

FRIL
Ferritin light chain

2

1

High-throughput

0.549

High

168840

TBA4A
Tubulin alpha-4A chain

2

3

High-throughput

0.549

High

168876

ZCH10
Zinc finger CCHC domain-containing protein 10

2

1

High-throughput

0.549

High

168785

TSN3
Tetraspanin-3

1

1

High-throughput

0.536

High

168808

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.536

High

168837

CCG7
Voltage-dependent calcium channel gamma-7 subunit

1

2

High-throughput

0.536

High

168855

ASIC2
Acid-sensing ion channel 2

1

1

High-throughput

0.536

High

168890

TMM74
Transmembrane protein 74

1

1

High-throughput

0.536

High

168850

IF4A2
Eukaryotic initiation factor 4A-II

1

0

High-throughput

0.517

High

168802

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.515

High

168788

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.513

High

168823

BASI
Basigin

1

0

High-throughput

0.513

High

168849

CUL3
Cullin-3

1

0

High-throughput

0.513

High

168882

BSND
Barttin

1

0

High-throughput

0.513

High

168856

HIF1A
Hypoxia-inducible factor 1-alpha

1

1

Small-scale

0.512

High

168880

KBTB7
Kelch repeat and BTB domain-containing protein 7

2

1

Small-scale

0.504

High

138414

BIN1
Myc box-dependent-interacting protein 1

1

3

Small-scale

0.501

High

168857

DDR2
Discoidin domain-containing receptor 2

1

3

High-throughput

0.500

High

168782

ZNRD2
Protein ZNRD2

1

1

High-throughput

0.489

High

168790

CIB2
Calcium and integrin-binding family member 2

1

1

High-throughput

0.489

High

168791

DNJB5
DnaJ homolog subfamily B member 5

1

6

High-throughput

0.489

High

168828

MAGA9
Melanoma-associated antigen 9

1

1

High-throughput

0.489

High

168839

DYLT1
Dynein light chain Tctex-type 1

1

1

High-throughput

0.489

High

168852

TEBP
Prostaglandin E synthase 3

1

2

High-throughput

0.489

High

168858

INSY1
Inhibitory synaptic factor 1

1

1

High-throughput

0.489

High

168872

TTC9C
Tetratricopeptide repeat protein 9C

1

2

High-throughput

0.489

High

168881

DYT2B
Dynein light chain Tctex-type protein 2B

1

1

High-throughput

0.489

High

168889

LURA1
Leucine rich adaptor protein 1

1

1

High-throughput

0.489

High

168908

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

2

High-throughput

0.489

High

168783

PRKN
E3 ubiquitin-protein ligase parkin

1

1

Small-scale

0.479

High

168795

BAG4
BAG family molecular chaperone regulator 4

1

2

High-throughput

0.479

High

168798

EGFR
Epidermal growth factor receptor

1

1

Small-scale

0.479

High

168812

BRAF
Serine/threonine-protein kinase B-raf

1

4

High-throughput

0.479

High

168814

KPCA
Protein kinase C alpha type

1

2

Small-scale

0.479

High

168822

OPRM
Mu-type opioid receptor

1

3

Small-scale

0.479

High

168827

PE2R3
Prostaglandin E2 receptor EP3 subtype

1

2

High-throughput

0.479

High

168832

HSP72
Heat shock-related 70 kDa protein 2

1

1

High-throughput

0.479

High

168867

PLD3
5'-3' exonuclease PLD3

1

1

High-throughput

0.479

High

168877

DJB14
DnaJ homolog subfamily B member 14

1

5

High-throughput

0.479

High

168883

AQP3
Aquaporin-3

1

4

Small-scale

0.479

High

168907

HACD3
Very-long-chain

1

2

High-throughput

0.479

High

168910

DNJB4
DnaJ homolog subfamily B member 4

1

6

High-throughput

0.479

High

168806

SRPRA
Signal recognition particle receptor subunit alpha

1

0

High-throughput

0.458

High

168826

MTOR
Serine/threonine-protein kinase mTOR

1

0

Small-scale

0.458

High

168831

PPP5
Serine/threonine-protein phosphatase 5

1

0

High-throughput

0.458

High

168844

CAV1
Caveolin-1

1

0

Small-scale

0.458

High

168895

CAB45
45 kDa calcium-binding protein

1

0

High-throughput

0.458

High

58759

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

1

High-throughput

0.445

High

168786

MOT2
Monocarboxylate transporter 2

1

1

High-throughput

0.445

High

168865

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

4

High-throughput

0.445

High

168870

S22AF
Solute carrier family 22 member 15

1

1

High-throughput

0.445

High

168789

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

168793

TOM70
Mitochondrial import receptor subunit TOM70

1

6

High-throughput

0.437

High

168797

BAG3
BAG family molecular chaperone regulator 3

1

2

High-throughput

0.437

High

168817

KS6B1
Ribosomal protein S6 kinase beta-1

1

3

Small-scale

0.437

High

168819

DNJB1
DnaJ homolog subfamily B member 1

1

6

High-throughput

0.437

High

168820

DNJA1
DnaJ homolog subfamily A member 1

1

7

High-throughput

0.437

High

168834

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

1

High-throughput

0.437

High

168836

PFD3
Prefoldin subunit 3

1

1

High-throughput

0.437

High

168846

SPAG1
Sperm-associated antigen 1

1

5

High-throughput

0.437

High

168851

PEA15
Astrocytic phosphoprotein PEA-15

1

1

Small-scale

0.437

High

168854

TOM34
Mitochondrial import receptor subunit TOM34

1

7

High-throughput

0.437

High

168868

ANKY2
Ankyrin repeat and MYND domain-containing protein 2

1

1

High-throughput

0.437

High

168892

TTC1
Tetratricopeptide repeat protein 1

1

7

High-throughput

0.437

High

168894

TBA1C
Tubulin alpha-1C chain

1

4

High-throughput

0.437

High

168897

TBB2B
Tubulin beta-2B chain

1

2

High-throughput

0.437

High

168899

EGLN1
Egl nine homolog 1

1

1

Small-scale

0.437

High

168900

RPAP3
RNA polymerase II-associated protein 3

1

5

High-throughput

0.437

High

168913

BAG5
BAG family molecular chaperone regulator 5

1

2

High-throughput

0.437

High

168811

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

168847

TRDN
Triadin

1

0

High-throughput

0.426

High

168891

S38A2
Sodium-coupled neutral amino acid symporter 2

1

0

High-throughput

0.426

High

168898

S39A8
Metal cation symporter ZIP8

1

0

High-throughput

0.426

High

168860

DCAF8
DDB1- and CUL4-associated factor 8

1

1

High-throughput

0.407

High

168863

HEAT3
HEAT repeat-containing protein 3

1

1

High-throughput

0.407

High

168864

KBTB6
Kelch repeat and BTB domain-containing protein 6

1

1

Small-scale

0.407

High

168887

EAF1
ELL-associated factor 1

1

1

High-throughput

0.407

High

168873

SPC24
Kinetochore protein Spc24

4

0

High-throughput

0.360

High

168879

CC107
Coiled-coil domain-containing protein 107

2

0

High-throughput

0.328

High

168859

HERC4
Probable E3 ubiquitin-protein ligase HERC4

2

0

High-throughput

0.318

High

168885

TM169
Transmembrane protein 169

2

0

High-throughput

0.313

High

168800

ALDOA
Fructose-bisphosphate aldolase A

1

0

Small-scale

0.292

High

168794

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

0

High-throughput

0.279

Low

168796

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

168862

ASGL1
Isoaspartyl peptidase/L-asparaginase

1

0

High-throughput

0.279

Low

168888

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.279

Low

168915

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

0

High-throughput

0.279

Low

168916

CRYL1
Lambda-crystallin homolog

1

0

High-throughput

0.279

Low

168871

RPTOR
Regulatory-associated protein of mTOR

1

0

Small-scale

0.269

Low

168810

UNG
Uracil-DNA glycosylase

1

0

High-throughput

0.268

Low

168779

XPO1
Exportin-1

1

0

High-throughput

0.249

Low

168784

NUPR1
Nuclear protein 1

1

0

High-throughput

0.249

Low

168792

RMP
Unconventional prefoldin RPB5 interactor 1

1

0

High-throughput

0.249

Low

168803

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

0

High-throughput

0.249

Low

168804

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

0

High-throughput

0.249

Low

168825

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

168830

TSP3
Thrombospondin-3

1

0

High-throughput

0.249

Low

168843

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.249

Low

168848

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

0

High-throughput

0.249

Low

168853

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

0

Small-scale

0.249

Low

168861

DDI2
Protein DDI1 homolog 2

1

0

High-throughput

0.249

Low

168875

COMA1

1

0

High-throughput

0.249

Low

168884

KBP
KIF-binding protein

1

0

High-throughput

0.249

Low

168896

MCMBP
Mini-chromosome maintenance complex-binding protein

1

0

High-throughput

0.249

Low

168901

INO1
Inositol-3-phosphate synthase 1

1

0

High-throughput

0.249

Low

168904

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

168905

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

0

High-throughput

0.249

Low

168906

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

0

High-throughput

0.249

Low

168911

TRM7
tRNA

1

0

High-throughput

0.249

Low

168781

MFS11
UNC93-like protein MFSD11

1

0

High-throughput

0.232

Low

168807

VSIG8
V-set and immunoglobulin domain-containing protein 8

1

0

High-throughput

0.232

Low

168869

MFS6L
Major facilitator superfamily domain-containing protein 6-like

1

0

High-throughput

0.232

Low

168909

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025