HitPredict

Interactor 1: MUSK (O15146)
Muscle, skeletal receptor tyrosine-protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor)
Gene: MUSK

Interactor 2: PTN1 (P18031)
Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)
Gene: PTPN1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 869 Hs			1 435
+	Hs
		434132 RET_HUMAN (493-869): 1.79e-118: 388: 33.85		PTN1_HUMAN (1-435): 0: 539: 100.00
+	Hs
		499261 KIT_HUMAN (19-865): 5.06e-153: 476: 18.88		PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44
+	Hs
		499258 KIT_HUMAN (19-865): 5.06e-153: 476: 18.88		PTN12_HUMAN (24-314): 1e-122: 376: 33.55
+	Hs
		411291 INSR_HUMAN (569-857): 8.73e-70: 254: 42.22		PTN1_HUMAN (1-435): 0: 539: 100.00
+	Hs
		434120 RET_HUMAN (493-869): 1.79e-118: 388: 33.85		PTPRF_HUMAN (19-278): 2.99e-105: 344: 30.94
+	Hs
		434133 RET_HUMAN (493-869): 1.79e-118: 388: 33.85		PTPRA_HUMAN (12-278): 9.1e-105: 330: 31.62
+	Hs
		411290 INSR_HUMAN (569-857): 8.73e-70: 254: 42.22		PTN2_HUMAN (3-435): 3.97e-156: 449: 52.98
+	Hs
		499270 KIT_HUMAN (19-865): 5.06e-153: 476: 18.88		PTPRO_HUMAN (20-274): 4.19e-48: 178: 38.31
+	Hs
		499259 KIT_HUMAN (19-865): 5.06e-153: 476: 18.88		PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80
+	Hs
		411297 INSR_HUMAN (569-857): 8.73e-70: 254: 42.22		PTPRB_HUMAN (2-311): 4.08e-124: 398: 34.39
+	Hs
		674402 UFO_HUMAN (7-868): 2.19e-152: 472: 20.51		PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80
+	Hs
		601500 FGFR2_HUMAN (21-330): 7.1e-72: 255: 20.05		PTN12_HUMAN (24-314): 1e-122: 376: 33.55
+	Rn
		976067 NTRK3_RAT (556-859): 2.02e-75: 265: 39.16		PTPRS_RAT (1-278): 1.01e-104: 343: 30.04
+	Hs
		434178 RET_HUMAN (493-869): 1.79e-118: 388: 33.85		PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80
+	Hs
		499281 KIT_HUMAN (19-865): 5.06e-153: 476: 18.88		PTPRU_HUMAN (341-434): 6.63e-17: 85.4: 13.59
+	Hs
		499236 KIT_HUMAN (19-865): 5.06e-153: 476: 18.88		PTN6_HUMAN (342-432): 1.75e-12: 71.2: 10.48
+	Hs
		411278 INSR_HUMAN (569-857): 8.73e-70: 254: 42.22		PTPRC_HUMAN (16-337): 3.28e-77: 263: 22.95
+	Hs
		601501 FGFR2_HUMAN (21-330): 7.1e-72: 255: 20.05		PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80
+	Hs
		411298 INSR_HUMAN (569-857): 8.73e-70: 254: 42.22		PTPRG_HUMAN (342-435): 1.43e-21: 99.7: 13.46
+	Hs
		601466 FGFR2_HUMAN (21-330): 7.1e-72: 255: 20.05		PTN6_HUMAN (342-432): 1.75e-12: 71.2: 10.48