Protein: ML12A
Myosin regulatory light chain 12A (Epididymis secretory protein Li 24) (HEL-S-24) (MLC-2B) (Myosin RLC) (Myosin regulatory light chain 2, nonsarcomeric) (Myosin regulatory light chain MRLC3)

Gene: ML12A, MYL12A
Organism: Homo sapiens
Interactions: 150
UniProt ID: P19105

Gene Ontology (top 5):
GO:0005509 - calcium ion binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016460 - myosin II complex
GO:0032036 - myosin heavy chain binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

618653

MYH9
Myosin-9

2

19

High-throughput

0.811

High

618717

MY18A
Unconventional myosin-XVIIIa

2

20

High-throughput

0.811

High

618690

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

2

8

High-throughput

0.754

High

169053

ML12B
Myosin regulatory light chain 12B

2

16

High-throughput

0.737

High

618646

MYL9
Myosin regulatory light polypeptide 9

1

16

High-throughput

0.691

High

618654

MYH10
Myosin-10

1

20

High-throughput

0.691

High

618669

NEK4
Serine/threonine-protein kinase Nek4

1

20

High-throughput

0.691

High

618709

MYH14
Myosin-14

1

19

High-throughput

0.691

High

618722

MYO19
Unconventional myosin-XIX

1

20

High-throughput

0.691

High

618664

GSK3A
Glycogen synthase kinase-3 alpha

1

19

High-throughput

0.656

High

563162

CFTR
Cystic fibrosis transmembrane conductance regulator

3

3

High-throughput

0.650

High

177788

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

17

High-throughput

0.618

High

618655

MYH11
Myosin-11

1

20

High-throughput

0.618

High

618656

TAGL2
Transgelin-2

1

20

High-throughput

0.618

High

618666

CDK7
Cyclin-dependent kinase 7

1

7

High-throughput

0.618

High

618679

ACTC
Actin, alpha cardiac muscle 1

1

7

High-throughput

0.618

High

618689

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

7

High-throughput

0.618

High

618715

ASB11
Ankyrin repeat and SOCS box protein 11

1

2

High-throughput

0.618

High

618730

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

9

High-throughput

0.618

High

618748

TNIK
TRAF2 and NCK-interacting protein kinase

1

5

High-throughput

0.618

High

618752

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

14

High-throughput

0.618

High

618677

GRB2
Growth factor receptor-bound protein 2

2

1

High-throughput

0.601

High

400253

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.586

High

618696

LARP7
La-related protein 7

2

3

High-throughput

0.584

High

156943

CTRO
Citron Rho-interacting kinase

1

19

Small-scale

0.575

High

618693

MYLK
Myosin light chain kinase, smooth muscle

1

19

Small-scale

0.575

High

618698

MRCKA
Serine/threonine-protein kinase MRCK alpha

1

14

Small-scale

0.575

High

240711

PRKN
E3 ubiquitin-protein ligase parkin

2

6

High-throughput

0.571

High

395465

ESR1
Estrogen receptor

2

3

High-throughput

0.571

High

618667

CDK9
Cyclin-dependent kinase 9

1

9

High-throughput

0.553

High

415339

HSPB1
Heat shock protein beta-1

1

6

High-throughput

0.541

High

135485

DNM1L
Dynamin-1-like protein

1

1

High-throughput

0.536

High

437565

MYL1
Myosin light chain 1/3, skeletal muscle isoform

1

20

High-throughput

0.536

High

573921

MYL6B
Myosin light chain 6B

1

20

High-throughput

0.536

High

618642

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

2

High-throughput

0.536

High

618662

CAZA2
F-actin-capping protein subunit alpha-2

1

4

High-throughput

0.536

High

618674

MYL6
Myosin light polypeptide 6

1

18

High-throughput

0.536

High

618685

FLII
Protein flightless-1 homolog

1

4

High-throughput

0.536

High

618695

LRRF1
Leucine-rich repeat flightless-interacting protein 1

1

4

High-throughput

0.536

High

618728

KIF2C
Kinesin-like protein KIF2C

1

10

High-throughput

0.536

High

618741

ANLN
Anillin

1

4

High-throughput

0.536

High

618742

PDLI7
PDZ and LIM domain protein 7

1

5

High-throughput

0.536

High

618659

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

2

Small-scale

0.516

High

254795

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

6

High-throughput

0.514

High

618713

IPO4
Importin-4

1

0

High-throughput

0.513

High

618727

PARK7
Parkinson disease protein 7

1

0

High-throughput

0.513

High

618729

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.513

High

618673

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

Small-scale

0.501

High

618658

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.493

High

618718

ESR2
Estrogen receptor beta

1

3

Small-scale

0.489

High

618725

RSF1
Remodeling and spacing factor 1

1

11

High-throughput

0.489

High

618753

LRRF2
Leucine-rich repeat flightless-interacting protein 2

1

20

High-throughput

0.489

High

323165

TRI37
E3 ubiquitin-protein ligase TRIM37

1

6

High-throughput

0.479

High

324510

HEXI1
Protein HEXIM1

1

2

High-throughput

0.479

High

336344

SVIL
Supervillin

1

3

Small-scale

0.479

High

370553

FOS
Protein c-Fos

1

2

High-throughput

0.479

High

409257

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

1

High-throughput

0.479

High

425303

ISG15
Ubiquitin-like protein ISG15

1

5

High-throughput

0.479

High

464798

SP1
Transcription factor Sp1

1

4

Small-scale

0.479

High

482307

F16P1
Fructose-1,6-bisphosphatase 1

1

1

High-throughput

0.479

High

484906

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

1

High-throughput

0.479

High

534610

BIP
Endoplasmic reticulum chaperone BiP

1

2

High-throughput

0.479

High

565138

ITA4
Integrin alpha-4

1

1

High-throughput

0.479

High

618643

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

1

High-throughput

0.479

High

618644

CBL
E3 ubiquitin-protein ligase CBL

1

8

High-throughput

0.479

High

618645

CRCM
Colorectal mutant cancer protein

1

19

High-throughput

0.479

High

618647

TNR6
Tumor necrosis factor receptor superfamily member 6

1

2

High-throughput

0.479

High

618648

S10A4
Protein S100-A4

1

2

High-throughput

0.479

High

618649

PML
Protein PML

1

11

High-throughput

0.479

High

618657

BRCA1
Breast cancer type 1 susceptibility protein

1

3

High-throughput

0.479

High

618661

YAP1
Transcriptional coactivator YAP1

1

2

High-throughput

0.479

High

618663

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.479

High

618672

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

1

High-throughput

0.479

High

618682

TFCP2
Alpha-globin transcription factor CP2

1

1

High-throughput

0.479

High

618683

TP53B
TP53-binding protein 1

1

2

High-throughput

0.479

High

618684

TRI26
Tripartite motif-containing protein 26

1

2

Small-scale

0.479

High

618687

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

618688

CUL3
Cullin-3

1

1

High-throughput

0.479

High

618692

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

618701

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.479

High

618704

ZN746
Zinc finger protein 746

1

1

High-throughput

0.479

High

618705

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

6

High-throughput

0.479

High

618706

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

618711

SMC5
Structural maintenance of chromosomes protein 5

1

5

High-throughput

0.479

High

618716

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

618719

REQU
Zinc finger protein ubi-d4

1

5

High-throughput

0.479

High

618720

FBXW7
F-box/WD repeat-containing protein 7

1

2

High-throughput

0.479

High

618726

RUFY1
RUN and FYVE domain-containing protein 1

1

18

High-throughput

0.479

High

618731

MEP50
Methylosome protein WDR77

1

4

High-throughput

0.479

High

618733

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

618734

TRI31
E3 ubiquitin-protein ligase TRIM31

1

4

High-throughput

0.479

High

618738

ECT2
Protein ECT2

1

7

High-throughput

0.479

High

618739

SENP2
Sentrin-specific protease 2

1

1

Small-scale

0.479

High

618743

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

618744

RNF12
E3 ubiquitin-protein ligase RLIM

1

4

High-throughput

0.479

High

618749

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

2

High-throughput

0.479

High

618751

TRAF6
TNF receptor-associated factor 6

1

6

High-throughput

0.479

High

618754

NEMO
NF-kappa-B essential modulator

1

20

High-throughput

0.479

High

618737

SUV92
Histone-lysine N-methyltransferase SUV39H2

1

2

High-throughput

0.464

High

247663

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

284062

SRS10
Serine/arginine-rich splicing factor 10

1

0

Small-scale

0.458

High

315099

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

606197

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

618651

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

618668

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

618670

MOT1
Monocarboxylate transporter 1

1

0

High-throughput

0.458

High

618676

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

618699

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

618702

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

618712

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

618714

NUDC2
NudC domain-containing protein 2

1

0

High-throughput

0.458

High

618740

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

618746

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

618747

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

618750

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.458

High

618732

KLF16
Krueppel-like factor 16

1

2

High-throughput

0.457

High

529045

TAU
Microtubule-associated protein tau

1

8

High-throughput

0.445

High

618652

BMI1
Polycomb complex protein BMI-1

1

4

High-throughput

0.445

High

618671

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.445

High

618678

1433Z
14-3-3 protein zeta/delta

1

8

High-throughput

0.445

High

618680

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

2

High-throughput

0.445

High

618710

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

8

High-throughput

0.445

High

618723

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

14

High-throughput

0.445

High

618736

P63
Tumor protein 63

1

5

Small-scale

0.445

High

371126

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.437

High

377956

TNFA
Tumor necrosis factor

1

1

High-throughput

0.437

High

472448

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

2

High-throughput

0.437

High

618641

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

2

High-throughput

0.437

High

618665

DNLI4
DNA ligase 4

1

1

High-throughput

0.437

High

618675

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.437

High

618681

GOGA2
Golgin subfamily A member 2

1

20

High-throughput

0.437

High

618686

TIF1B
Transcription intermediary factor 1-beta

1

11

High-throughput

0.437

High

618691

MDC1
Mediator of DNA damage checkpoint protein 1

1

4

High-throughput

0.437

High

618694

EZH2
Histone-lysine N-methyltransferase EZH2

1

4

High-throughput

0.437

High

618703

TET2
Methylcytosine dioxygenase TET2

1

1

Small-scale

0.437

High

618707

PAXI1
PAX-interacting protein 1

1

6

High-throughput

0.437

High

618708

MEPCE
7SK snRNA methylphosphate capping enzyme

1

1

High-throughput

0.437

High

618724

KCD15
BTB/POZ domain-containing protein KCTD15

1

1

Small-scale

0.437

High

618745

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

1

High-throughput

0.437

High

429279

JUN
Transcription factor Jun

1

1

High-throughput

0.407

High

618721

LIN37
Protein lin-37 homolog

1

1

Small-scale

0.407

High

618650

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.279

Low

254519

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.269

Low

297448

PIAS1
E3 SUMO-protein ligase PIAS1

1

0

High-throughput

0.249

Low

378828

CD4
T-cell surface glycoprotein CD4

1

0

Small-scale

0.249

Low

618660

NKX21
Homeobox protein Nkx-2.1

1

0

High-throughput

0.249

Low

618700

OBI1
ORC ubiquitin ligase 1

1

0

Small-scale

0.249

Low

618735

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

344089

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.232

Low

618697

LIN9
Protein lin-9 homolog

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025