HitPredict

Interactor 1: MDM4 (O15151)
Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4)
Gene: MDM4

Interactor 2: S100B (P04271)
Protein S100-B (S-100 protein beta chain) (S-100 protein subunit beta) (S100 calcium-binding protein B)
Gene: S100B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	17010455, 31837246
Identification Methods	unspecified method, fluorescence polarization spectroscopy, isothermal titration calorimetry
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008270 - zinc ion binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 490 Hs			1 92
+	Hs
		169240 MDM4_HUMAN (1-490): 0: 692: 100.00		S10A1_HUMAN (2-89): 2.93e-33: 111: 60.23
+	Hs
		169242 MDM4_HUMAN (1-490): 0: 692: 100.00		S10A2_HUMAN (2-90): 1.34e-29: 102: 44.94
+	Hs
		169246 MDM4_HUMAN (1-490): 0: 692: 100.00		S10A5_HUMAN (2-92): 2.82e-22: 84.1: 39.56
+	Hs
		962851 MDM2_HUMAN (2-488): 0: 554: 31.56		HORN_HUMAN (1-92): 1.99e-34: 125: 30.44
+	Hs
		615210 MDM2_HUMAN (2-488): 0: 554: 31.56		S10A1_HUMAN (2-89): 2.93e-33: 111: 60.23
+	Hs
		380767 MDM2_HUMAN (2-488): 0: 554: 31.56		S100B_HUMAN (1-92): 9.54e-32: 107: 100.00
+	Hs
		642935 MDM2_HUMAN (2-488): 0: 554: 31.56		S10A4_HUMAN (3-90): 2.3e-30: 104: 47.73
+	Hs
		661229 MDM2_HUMAN (2-488): 0: 554: 31.56		S10A2_HUMAN (2-90): 1.34e-29: 102: 44.94
+	Hs
		416609 MDM2_HUMAN (2-488): 0: 554: 31.56		S10A6_HUMAN (3-90): 7.15e-24: 87.9: 39.77