HitPredict

Interactor 1: MDM4 (O15151)
Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4)
Gene: MDM4

Interactor 2: CDN2A (P42771)
Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A)
Gene: CDKN2A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	28205554, 11297540
Identification Methods	fluorescent resonance energy transfer, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0008285 - negative regulation of cell population proliferation GO:0045892 - negative regulation of DNA-templated transcription GO:0051726 - regulation of cell cycle
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 490 Hs			1 156
+	Hs
		169253 MDM4_HUMAN (1-490): 0: 692: 100.00		CDN2B_HUMAN (3-136): 4.71e-52: 163: 81.34
+	Hs
		790750 MDM2_HUMAN (2-488): 0: 554: 31.56		CDN2A_HUMAN (1-156): 1.38e-51: 163: 100.00
+	Hs
		790924 MDM2_HUMAN (2-488): 0: 554: 31.56		CDN2B_HUMAN (3-136): 4.71e-52: 163: 81.34
+	Hs
		962978 MDM2_HUMAN (2-488): 0: 554: 31.56		EHMT1_HUMAN (4-121): 1.19e-30: 117: 19.33
+	Hs
		257601 MDM2_HUMAN (2-488): 0: 554: 31.56		ANR17_HUMAN (69-147): 2.99e-19: 85.1: 20.25
+	Hs
		862026 MDM2_HUMAN (2-488): 0: 554: 31.56		DAPK1_HUMAN (49-155): 4.06e-14: 70.4: 22.02
+	Hs
		276169 MDM2_HUMAN (2-488): 0: 554: 31.56		PSD10_HUMAN (1-85): 4.57e-12: 63.1: 23.86