Protein: PDI
Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Thioredoxin-related glycoprotein 1)

Gene: PDI, PDI1
Organism: Saccharomyces cerevisiae S288C
Interactions: 159
UniProt ID: P17967

Gene Ontology (top 5):
GO:0003756 - protein disulfide isomerase activity
GO:0005783 - endoplasmic reticulum
GO:0005788 - endoplasmic reticulum lumen
GO:0006457 - protein folding
GO:0015035 - protein-disulfide reductase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

610147

MNL1
ER degradation-enhancing alpha-mannosidase-like protein 1

8

12

Small-scale

0.974

High

610086

PDI
Protein disulfide-isomerase

2

17

Small-scale

0.836

High

610191

ERO1
Endoplasmic oxidoreductin-1

6

14

Small-scale

0.723

High

522988

HSP71
Heat shock protein SSA1

3

5

High-throughput

0.633

High

610098

SCJ1
DnaJ-related protein SCJ1

1

1

High-throughput

0.618

High

610117

EUG1
Protein disulfide-isomerase EUG1

1

16

High-throughput

0.618

High

610160

EPS1
ER-retained PMA1-suppressing protein 1

1

18

High-throughput

0.618

High

610210

MPD1
Protein disulfide-isomerase MPD1

1

18

High-throughput

0.618

High

610214

MPD2
Protein disulfide isomerase MPD2

1

1

High-throughput

0.618

High

610113

HS104
Heat shock protein 104

3

0

Small-scale

0.606

High

366037

CBPY
Carboxypeptidase Y

2

3

Small-scale

0.584

High

610161

SGN1
RNA-binding protein SGN1

1

0

High-throughput

0.578

High

610152

RSP5
E3 ubiquitin-protein ligase RSP5

2

6

High-throughput

0.543

High

578209

TAL1
Transaldolase

2

1

High-throughput

0.526

High

477510

MYO1
Myosin-1

1

2

Small-scale

0.504

High

610088

FKBP
FK506-binding protein 1

1

16

High-throughput

0.500

High

365903

PPA5
Repressible acid phosphatase

1

6

High-throughput

0.489

High

585846

CSK21
Casein kinase II subunit alpha

1

5

High-throughput

0.489

High

610090

MDHC
Malate dehydrogenase, cytoplasmic

1

6

High-throughput

0.489

High

610194

TDA1
Serine/threonine-protein kinase TDA1

1

5

High-throughput

0.489

High

610156

DOA10
ERAD-associated E3 ubiquitin-protein ligase DOA10

1

0

High-throughput

0.480

High

454275

CARP
Saccharopepsin

1

5

High-throughput

0.479

High

578797

HSC82
ATP-dependent molecular chaperone HSC82

1

7

High-throughput

0.479

High

597026

BIP
Endoplasmic reticulum chaperone BiP

1

19

High-throughput

0.479

High

610089

KRE5
Killer toxin-resistance protein 5

1

7

High-throughput

0.479

High

610095

CYPB
Peptidyl-prolyl cis-trans isomerase B

1

15

High-throughput

0.479

High

610097

PPA3
Constitutive acid phosphatase

1

6

High-throughput

0.479

High

610107

CHIT
Endochitinase

1

1

High-throughput

0.479

High

610112

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

3

Small-scale

0.479

High

610116

FKBP2
Peptidyl-prolyl cis-trans isomerase FPR2

1

17

High-throughput

0.479

High

610118

HSP7F
Heat shock protein homolog SSE1

1

13

High-throughput

0.479

High

610122

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

3

Small-scale

0.479

High

610123

CYPD
Peptidyl-prolyl cis-trans isomerase D

1

14

High-throughput

0.479

High

610128

LHS1
Heat shock protein 70 homolog LHS1

1

11

High-throughput

0.479

High

610130

DCW1
Mannan endo-1,6-alpha-mannosidase DCW1

1

1

High-throughput

0.479

High

610135

GLU2A
Glucosidase 2 subunit alpha

1

7

High-throughput

0.479

High

610137

ECM33
Cell wall protein ECM33

1

1

High-throughput

0.479

High

610145

GPI16
GPI transamidase component GPI16

1

1

High-throughput

0.479

High

610148

CH10
10 kDa heat shock protein, mitochondrial

1

6

High-throughput

0.479

High

610149

PLB1
Lysophospholipase 1

1

2

High-throughput

0.479

High

610153

YEH8
Uncharacterized protein YEL068C

1

1

High-throughput

0.479

High

610158

SIM1
Probable secreted beta-glucosidase SIM1

1

4

High-throughput

0.479

High

610164

MID1
Stretch-activated cation channel MID1

1

1

High-throughput

0.479

High

610167

YFI8
Uncharacterized protein YFR018C

1

4

High-throughput

0.479

High

610169

TOH1
Probable circularly permuted 1,3-beta-glucanase YJL171C

1

3

High-throughput

0.479

High

610170

CIS3
Cell wall mannoprotein CIS3

1

1

High-throughput

0.479

High

610186

TMEDA
Endoplasmic reticulum vesicle protein 25

1

5

High-throughput

0.479

High

610196

PLB2
Lysophospholipase 2

1

2

High-throughput

0.479

High

610200

GLU2B
Glucosidase 2 subunit beta

1

3

High-throughput

0.479

High

610201

SCW10
Probable family 17 glucosidase SCW10

1

5

High-throughput

0.479

High

610202

DFG5
Mannan endo-1,6-alpha-mannosidase DFG5

1

1

High-throughput

0.479

High

610203

GAS5
1,3-beta-glucanosyltransferase GAS5

1

5

High-throughput

0.479

High

610204

SIL1
Nucleotide exchange factor SIL1

1

1

High-throughput

0.479

High

610206

PER33
Pore and endoplasmic reticulum protein of 33 kDa

1

1

Small-scale

0.479

High

610207

POM33
Pore membrane protein of 33 kDa

1

1

Small-scale

0.479

High

610213

OS9
Protein OS-9 homolog

1

1

High-throughput

0.479

High

610099

ADP1
Probable ATP-dependent permease

1

0

High-throughput

0.458

High

610129

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.458

High

610166

FET5
Iron transport multicopper oxidase FET5

1

0

High-throughput

0.458

High

610173

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.458

High

610178

VPS62
Vacuolar protein sorting-associated protein 62

1

0

High-throughput

0.458

High

574628

KSS1
Mitogen-activated protein kinase KSS1

1

3

High-throughput

0.457

High

610100

SSK22
Serine/threonine-protein kinase SSK22

1

5

High-throughput

0.457

High

610126

NNK1
Nitrogen network kinase 1

1

2

High-throughput

0.457

High

610142

KSP1
Serine/threonine-protein kinase KSP1

1

4

High-throughput

0.457

High

610189

FRK1
Fatty acyl-CoA synthetase and RNA processing-associated kinase 1

1

4

High-throughput

0.457

High

610087

PRP6
Pre-mRNA-splicing factor 6

1

3

High-throughput

0.457

High

610151

RV167
Reduced viability upon starvation protein 167

1

2

High-throughput

0.457

High

610192

YMZ2
WD repeat-containing protein YMR102C

1

6

High-throughput

0.457

High

610212

AP2M
AP-2 complex subunit mu

1

1

High-throughput

0.457

High

481470

HSP73
Heat shock protein SSA3

1

5

High-throughput

0.445

High

543742

SSB1
Ribosome-associated molecular chaperone SSB1

1

6

High-throughput

0.445

High

610143

SSZ1
Ribosome-associated complex subunit SSZ1

1

5

High-throughput

0.445

High

610154

HSP7E
Heat shock protein SSC3, mitochondrial

1

18

High-throughput

0.445

High

365552

PGK
Phosphoglycerate kinase

1

5

High-throughput

0.437

High

368583

PMG1
Phosphoglycerate mutase 1

1

7

High-throughput

0.437

High

420877

PMA1
Plasma membrane ATPase 1

1

1

High-throughput

0.437

High

439231

PDC1
Pyruvate decarboxylase isozyme 1

1

1

High-throughput

0.437

High

454074

DHE4
NADP-specific glutamate dehydrogenase 1

1

1

High-throughput

0.437

High

479962

PRTB
Cerevisin

1

3

High-throughput

0.437

High

554113

BAR1
Barrierpepsin

1

5

High-throughput

0.437

High

555000

G6PI
Glucose-6-phosphate isomerase

1

1

High-throughput

0.437

High

585525

BGL2
Glucan 1,3-beta-glucosidase

1

7

High-throughput

0.437

High

603401

VATA
V-type proton ATPase catalytic subunit A

1

5

High-throughput

0.437

High

610091

CLH
Clathrin heavy chain

1

1

High-throughput

0.437

High

610092

GAS1
1,3-beta-glucanosyltransferase GAS1

1

5

High-throughput

0.437

High

610094

RAD53
Serine/threonine-protein kinase RAD53

1

3

High-throughput

0.437

High

610096

EXG1
Glucan 1,3-beta-glucosidase I/II

1

1

High-throughput

0.437

High

610101

YCE9
Uncharacterized protein YCL049C

1

1

High-throughput

0.437

High

610102

CDC48
Cell division control protein 48

1

9

High-throughput

0.437

High

610103

SPB4
ATP-dependent rRNA helicase SPB4

1

1

High-throughput

0.437

High

610104

CBPS
Carboxypeptidase S

1

3

High-throughput

0.437

High

610105

KRE2
Glycolipid 2-alpha-mannosyltransferase

1

6

High-throughput

0.437

High

610106

KTR1
Alpha-1,2 mannosyltransferase KTR1

1

6

High-throughput

0.437

High

610108

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

610109

TF3B
Transcription factor IIIB 70 kDa subunit

1

2

High-throughput

0.437

High

610110

BMH1
Protein BMH1

1

4

High-throughput

0.437

High

610114

VPS10
Vacuolar protein sorting/targeting protein VPS10

1

2

High-throughput

0.437

High

610120

CRH2
Congo red hypersensitive protein 2

1

2

High-throughput

0.437

High

610121

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.437

High

610124

DEF1
RNA polymerase II degradation factor 1

1

4

High-throughput

0.437

High

610125

PPAB
Acid phosphatase PHO11

1

6

High-throughput

0.437

High

610127

CENPA
Histone H3-like centromeric protein CSE4

1

3

High-throughput

0.437

High

610131

UTH1
Probable secreted beta-glucosidase UTH1

1

4

High-throughput

0.437

High

610132

APE3
Aminopeptidase Y

1

1

High-throughput

0.437

High

610133

ATG42
Vacuolar serine-type carboxypeptidase ATG42

1

3

High-throughput

0.437

High

610134

KTR3
Probable mannosyltransferase KTR3

1

6

High-throughput

0.437

High

610136

ATG8
Autophagy-related protein 8

1

12

High-throughput

0.437

High

610139

TOS1
Probable circularly permuted 1,3-beta-glucanase TOS1

1

3

High-throughput

0.437

High

610140

YPT31
GTP-binding protein YPT31/YPT8

1

1

High-throughput

0.437

High

610141

YGP1
Protein YGP1

1

1

High-throughput

0.437

High

610144

ECM14
Inactive metallocarboxypeptidase ECM14

1

6

High-throughput

0.437

High

610146

YH02
Uncharacterized protein YHR202W

1

1

High-throughput

0.437

High

610159

KTR7
Probable mannosyltransferase KTR7

1

6

High-throughput

0.437

High

610163

GPX3
Glutathione peroxidase-like peroxiredoxin HYR1

1

5

Small-scale

0.437

High

610171

YJN2
Uncharacterized protein YJL132W

1

1

High-throughput

0.437

High

610175

CWH41
Mannosyl-oligosaccharide glucosidase

1

2

High-throughput

0.437

High

610177

PESC
Pescadillo homolog

1

1

High-throughput

0.437

High

610179

CRH1
Congo red hypersensitive protein 1 [Includes: Chitinase CRH1

1

3

High-throughput

0.437

High

610180

SCW4
Probable family 17 glucosidase SCW4

1

5

High-throughput

0.437

High

610181

SUN4
Probable secreted beta-glucosidase SUN4

1

4

High-throughput

0.437

High

610182

YN95
Uncharacterized membrane glycoprotein YNR066C

1

2

High-throughput

0.437

High

610183

GIS2
Zinc finger protein GIS2

1

1

High-throughput

0.437

High

610188

RNY1
Ribonuclease T2-like

1

1

High-throughput

0.437

High

610193

TOM1
E3 ubiquitin-protein ligase TOM1

1

6

High-throughput

0.437

High

610195

GAS3
Probable 1,3-beta-glucanosyltransferase GAS3

1

5

High-throughput

0.437

High

610198

GIS1
Transcriptional activator/repressor GIS1

1

4

High-throughput

0.437

High

610199

YD415
Probable aminopeptidase YDR415C

1

1

High-throughput

0.437

High

610208

SLP1
Uncharacterized protein SLP1

1

1

High-throughput

0.437

High

610209

DBP10
ATP-dependent RNA helicase DBP10

1

2

High-throughput

0.437

High

610187

2ABA
Protein phosphatase PP2A regulatory subunit B

2

0

High-throughput

0.322

High

603000

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.279

Low

610115

CDC11
Cell division control protein 11

1

0

High-throughput

0.279

Low

541269

HEM6
Oxygen-dependent coproporphyrinogen-III oxidase

1

0

High-throughput

0.269

Low

610111

PSK1
Serine/threonine-protein kinase PSK1

1

0

High-throughput

0.261

Low

610165

BNI1
Protein BNI1

1

0

High-throughput

0.261

Low

610168

TOS3
Serine/threonine-protein kinase TOS3

1

0

High-throughput

0.261

Low

610197

ENT5
Epsin-5

1

0

Small-scale

0.261

Low

401872

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.249

Low

416365

HXKA
Hexokinase-1

1

0

High-throughput

0.249

Low

430776

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

0

Small-scale

0.249

Low

450701

KAD2
Adenylate kinase

1

0

High-throughput

0.249

Low

572507

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.249

Low

610093

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.249

Low

610119

GDA1
Guanosine-diphosphatase

1

0

High-throughput

0.249

Low

610138

GID4
GID complex substrate-recognition subunit 4

1

0

High-throughput

0.249

Low

610150

MNN1
Alpha-1,3-mannosyltransferase MNN1

1

0

High-throughput

0.249

Low

610162

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

610172

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

610174

HGH1
Protein HGH1

1

0

Small-scale

0.249

Low

610176

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.249

Low

610184

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

610185

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

0

High-throughput

0.249

Low

610190

COFI
Cofilin

1

0

High-throughput

0.249

Low

610205

YG11A
Transposon Ty1-GR1 Gag polyprotein

1

0

High-throughput

0.249

Low

610211

NPC2
Phosphatidylglycerol/phosphatidylinositol transfer protein

1

0

High-throughput

0.249

Low

610155

YE19
Uncharacterized protein YER189W

1

0

High-throughput

0.238

Low

610157

PSF2
DNA replication complex GINS protein PSF2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025