HitPredict

Interactor 1: MDM4 (O15151)
Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4)
Gene: MDM4

Interactor 2: UB2D1 (P51668)
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
Gene: UBE2D1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	12393902, 17301054
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_3
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 490 Hs			1 147
+	Hs
		169270 MDM4_HUMAN (1-490): 0: 692: 100.00		UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12
+	Hs
		169262 MDM4_HUMAN (1-490): 0: 692: 100.00		UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44
+	Hs
		963034 MDM2_HUMAN (2-488): 0: 554: 31.56		UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84
+	Hs
		849309 MDM2_HUMAN (2-488): 0: 554: 31.56		UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00
+	Hs
		919708 MDM2_HUMAN (2-488): 0: 554: 31.56		UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12
+	Hs
		895778 MDM2_HUMAN (2-488): 0: 554: 31.56		UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44
+	Hs
		962924 MDM2_HUMAN (2-488): 0: 554: 31.56		UB2E2_HUMAN (4-146): 3.11e-74: 221: 62.94
+	Hs
		962909 MDM2_HUMAN (2-488): 0: 554: 31.56		UB2E3_HUMAN (4-146): 1.2e-73: 220: 62.94
+	Mm
		620834 MDM2_MOUSE (2-488): 0: 532: 29.78		UB2D1_MOUSE (1-147): 3.24e-82: 239: 100.00
+	Hs
		851803 MDM2_HUMAN (2-488): 0: 554: 31.56		UB2E1_HUMAN (4-146): 3.94e-72: 216: 62.94
+	Mm
		620833 MDM2_MOUSE (2-488): 0: 532: 29.78		UB2D3_MOUSE (1-147): 9.08e-81: 236: 88.44
+	Hs
		828987 MDM2_HUMAN (2-488): 0: 554: 31.56		UBE2A_HUMAN (2-144): 2.83e-70: 209: 40.56
+	Hs
		927746 MDM2_HUMAN (2-488): 0: 554: 31.56		UBE2B_HUMAN (2-144): 1.35e-69: 208: 39.16
+	Hs
		896417 MDM2_HUMAN (2-488): 0: 554: 31.56		UBE2N_HUMAN (4-147): 1.92e-68: 205: 45.83