HitPredict

Interactor 1: WDR46 (O15213)
WD repeat-containing protein 46 (WD repeat-containing protein BING4)
Gene: WDR46

Interactor 2: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SET~WD40
Common GO terms	GO:0005654 - nucleoplasm GO:0005730 - nucleolus
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 610 Hs			1 1365
+	Hs
		69563 B0UZZ8_HUMAN (1-610): 1.27e-169: 498: 99.84		NSD2_HUMAN (1-1365): 0: 980: 100.00
+	Hs
		203735 DAW1_HUMAN (58-427): 1.67e-94: 298: 13.46		SUV91_HUMAN (830-1202): 5.28e-73: 251: 20.52
+	Hs
		1080474 PRP19_HUMAN (10-474): 4.42e-82: 268: 14.70		EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48
+	At
		1319861 WDR5A_ARATH (311-514): 1.57e-48: 173: 13.74		ATX1_ARATH (721-1213): 1.34e-72: 266: 17.23
+	Hs
		903444 WDR5_HUMAN (309-535): 1.07e-51: 183: 14.35		EHMT2_HUMAN (889-1199): 3.73e-54: 209: 20.65
+	Hs
		1080207 FBXW7_HUMAN (303-522): 5.74e-37: 148: 12.00		EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48
+	Hs
		1281314 FBXW7_HUMAN (303-522): 5.74e-37: 148: 12.00		EHMT2_HUMAN (889-1199): 3.73e-54: 209: 20.65
+	Hs
		903149 WDR5_HUMAN (309-535): 1.07e-51: 183: 14.35		KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05
+	Hs
		903604 WDR5_HUMAN (309-535): 1.07e-51: 183: 14.35		KMT2B_HUMAN (1049-1203): 1.21e-41: 170: 32.05
+	Hs
		267764 TAF5L_HUMAN (204-463): 1.14e-29: 125: 20.61		EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48
+	Hs
		921577 GBB2_HUMAN (291-489): 3.52e-28: 117: 8.50		EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48
+	Hs
		975303 FBXW7_HUMAN (303-522): 5.74e-37: 148: 12.00		KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05
+	Hs
		1317584 NLE1_HUMAN (43-222): 1.83e-14: 78.2: 12.78		SETD2_HUMAN (852-1238): 1.1e-53: 209: 27.74
+	Hs
		560881 GBB3_HUMAN (391-493): 6.93e-11: 65.9: 9.71		EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48
+	Hs
		152622 WDR5_HUMAN (309-535): 1.07e-51: 183: 14.35		KMT2D_HUMAN (69-660): 1.16e-09: 65.7: 8.54
+	Hs
		152663 WDR5B_HUMAN (309-535): 1.26e-49: 177: 13.91		KMT2D_HUMAN (69-660): 1.16e-09: 65.7: 8.54
+	Hs
		152678 FBXW7_HUMAN (303-522): 5.74e-37: 148: 12.00		KMT2D_HUMAN (69-660): 1.16e-09: 65.7: 8.54