Protein: MED28
Mediator of RNA polymerase II transcription subunit 28 (Endothelial-derived protein 1) (Mediator complex subunit 28) (Merlin and Grb2-interacting cytoskeletal protein) (Magicin) (Tumor angiogenesis marker EG-1)

Gene: MED28
Organism: Homo sapiens
Interactions: 110
UniProt ID: Q9H204

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0016592 - mediator complex
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1293701

MED30
Mediator of RNA polymerase II transcription subunit 30

8

1

Small-scale

0.969

High

1328955

MED29
Mediator of RNA polymerase II transcription subunit 29

6

1

Small-scale

0.949

High

1074727

MED22
Mediator of RNA polymerase II transcription subunit 22

6

0

Small-scale

0.897

High

1328956

MED11
Mediator of RNA polymerase II transcription subunit 11

6

0

Small-scale

0.894

High

826355

CDK8
Cyclin-dependent kinase 8

10

2

High-throughput

0.756

High

1314880

CDK19
Cyclin-dependent kinase 19

8

2

High-throughput

0.749

High

1328953

MED17
Mediator of RNA polymerase II transcription subunit 17

7

1

Small-scale

0.748

High

1076199

MED1
Mediator of RNA polymerase II transcription subunit 1

7

1

Small-scale

0.747

High

1328951

MED20
Mediator of RNA polymerase II transcription subunit 20

7

1

Small-scale

0.747

High

1328957

MED13
Mediator of RNA polymerase II transcription subunit 13

7

1

Small-scale

0.746

High

624509

CCNC
Cyclin-C

7

1

High-throughput

0.743

High

270529

MED6
Mediator of RNA polymerase II transcription subunit 6

6

1

Small-scale

0.732

High

1274344

MED12
Mediator of RNA polymerase II transcription subunit 12

6

1

Small-scale

0.732

High

48723

MED19
Mediator of RNA polymerase II transcription subunit 19

9

0

Small-scale

0.722

High

1037099

MED21
Mediator of RNA polymerase II transcription subunit 21

7

0

Small-scale

0.717

High

225418

MED14
Mediator of RNA polymerase II transcription subunit 14

5

1

High-throughput

0.714

High

1174777

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

5

1

High-throughput

0.712

High

206651

MED7
Mediator of RNA polymerase II transcription subunit 7

6

0

High-throughput

0.705

High

313465

MED26
Mediator of RNA polymerase II transcription subunit 26

6

0

High-throughput

0.705

High

1312760

MED18
Mediator of RNA polymerase II transcription subunit 18

6

0

High-throughput

0.705

High

1328952

MED4
Mediator of RNA polymerase II transcription subunit 4

6

0

High-throughput

0.704

High

1158922

MED27
Mediator of RNA polymerase II transcription subunit 27

6

0

Small-scale

0.701

High

1291844

MED8
Mediator of RNA polymerase II transcription subunit 8

6

0

Small-scale

0.699

High

1312294

MED10
Mediator of RNA polymerase II transcription subunit 10

5

0

High-throughput

0.688

High

1328954

MED9
Mediator of RNA polymerase II transcription subunit 9

5

0

High-throughput

0.688

High

1328963

MED31
Mediator of RNA polymerase II transcription subunit 31

5

0

High-throughput

0.688

High

265361

MED24
Mediator of RNA polymerase II transcription subunit 24

5

0

High-throughput

0.684

High

625035

RPB1
DNA-directed RNA polymerase II subunit RPB1

5

0

High-throughput

0.684

High

1301090

MED15
Mediator of RNA polymerase II transcription subunit 15

5

0

High-throughput

0.684

High

1328962

MED16
Mediator of RNA polymerase II transcription subunit 16

5

0

High-throughput

0.684

High

1206159

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

3

1

High-throughput

0.667

High

1174962

MED25
Mediator of RNA polymerase II transcription subunit 25

4

0

High-throughput

0.664

High

1328960

MED23
Mediator of RNA polymerase II transcription subunit 23

4

0

High-throughput

0.664

High

677000

RPB2
DNA-directed RNA polymerase II subunit RPB2

4

0

High-throughput

0.657

High

412351

FYN
Tyrosine-protein kinase Fyn

2

8

Small-scale

0.649

High

924856

GRB2
Growth factor receptor-bound protein 2

2

7

Small-scale

0.646

High

1328958

PUF60
Poly(U)-binding-splicing factor PUF60

2

1

High-throughput

0.640

High

583795

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

3

0

High-throughput

0.638

High

181454

RPB4
DNA-directed RNA polymerase II subunit RPB4

3

0

High-throughput

0.628

High

583576

RPB3
DNA-directed RNA polymerase II subunit RPB3

3

0

High-throughput

0.628

High

854467

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

3

0

High-throughput

0.628

High

523146

SRC
Proto-oncogene tyrosine-protein kinase Src

2

8

Small-scale

0.612

High

1221360

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

2

0

High-throughput

0.585

High

1281383

FBXW7
F-box/WD repeat-containing protein 7

2

0

Small-scale

0.585

High

411851

LCK
Tyrosine-protein kinase Lck

2

8

Small-scale

0.581

High

1262874

TCP11
T-complex protein 11 homolog

2

0

High-throughput

0.580

High

719611

MERL
Merlin

1

0

Small-scale

0.569

High

913952

RPB7
DNA-directed RNA polymerase II subunit RPB7

2

0

High-throughput

0.559

High

921163

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

2

0

High-throughput

0.559

High

1328950

MED28
Mediator of RNA polymerase II transcription subunit 28

2

0

High-throughput

0.559

High

1297022

ANM6
Protein arginine N-methyltransferase 6

1

0

High-throughput

0.549

High

796348

MAGAB
Melanoma-associated antigen 11

1

0

High-throughput

0.518

High

129332

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

11

Small-scale

0.515

High

442883

HCK
Tyrosine-protein kinase HCK

1

8

Small-scale

0.515

High

655464

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

3

Small-scale

0.515

High

986396

BTK
Tyrosine-protein kinase BTK

1

8

Small-scale

0.515

High

1136437

MAGI3
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

1

1

Small-scale

0.515

High

1326734

WWTR1
WW domain-containing transcription regulator protein 1

1

3

Small-scale

0.515

High

897950

RAP1B
Ras-related protein Rap-1b

1

0

High-throughput

0.513

High

959972

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.513

High

1160892

FXL19
F-box/LRR-repeat protein 19

1

0

High-throughput

0.513

High

173606

NPHP1
Nephrocystin-1

1

0

Small-scale

0.493

High

207834

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

1

0

Small-scale

0.493

High

1016146

ARHG5
Rho guanine nucleotide exchange factor 5

1

0

Small-scale

0.493

High

1299629

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

0

Small-scale

0.493

High

791971

HD
Huntingtin

1

0

High-throughput

0.493

High

1267704

NDRG1
Protein NDRG1

1

0

High-throughput

0.493

High

433471

YES
Tyrosine-protein kinase Yes

1

8

Small-scale

0.488

High

266423

TAD2A
Transcriptional adapter 2-alpha

1

1

High-throughput

0.479

High

808917

YAP1
Transcriptional coactivator YAP1

1

3

Small-scale

0.479

High

789008

TEC
Tyrosine-protein kinase Tec

1

8

Small-scale

0.470

High

789091

ABL2
Tyrosine-protein kinase ABL2

1

8

Small-scale

0.470

High

1270616

STAM1
Signal transducing adapter molecule 1

1

1

Small-scale

0.470

High

1272161

OSTF1
Osteoclast-stimulating factor 1

1

1

Small-scale

0.470

High

642794

ELAV4
ELAV-like protein 4

1

1

High-throughput

0.470

High

244926

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

246613

MCE1
mRNA-capping enzyme

1

0

High-throughput

0.458

High

299127

SASH1
SAM and SH3 domain-containing protein 1

1

0

Small-scale

0.458

High

304654

SCAF4
SR-related and CTD-associated factor 4

1

0

High-throughput

0.458

High

738881

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

High-throughput

0.458

High

841879

CDK9
Cyclin-dependent kinase 9

1

0

High-throughput

0.458

High

854363

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.458

High

864985

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.458

High

1076290

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

1132736

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

0

High-throughput

0.458

High

1137949

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

0

High-throughput

0.458

High

1173763

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

1328959

RCOR1
REST corepressor 1

1

0

High-throughput

0.458

High

73041

B4DUB1
cDNA FLJ50029, highly similar to Cell division cycle 2-like protein kinase 6

1

2

High-throughput

0.445

High

91310

E5RFK5
Cyclin-C

1

1

High-throughput

0.445

High

233786

NDK8
Putative nucleoside diphosphate kinase

1

0

High-throughput

0.426

High

473880

MYZAP
Myocardial zonula adherens protein

1

0

High-throughput

0.426

High

831679

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

1238893

CBY2
Protein chibby homolog 2

3

0

High-throughput

0.352

High

329044

TCL1B
T-cell leukemia/lymphoma protein 1B

3

0

High-throughput

0.347

High

849815

SUOX
Sulfite oxidase, mitochondrial

2

0

High-throughput

0.316

High

1128785

MIIP
Migration and invasion-inhibitory protein

2

0

High-throughput

0.316

High

1150692

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

2

0

High-throughput

0.305

High

1120813

KLH12
Kelch-like protein 12

1

0

High-throughput

0.282

High

1236704

USBP1
Harmonin-binding protein USHBP1

1

0

High-throughput

0.282

High

570651

DCAM
S-adenosylmethionine decarboxylase proenzyme

1

0

High-throughput

0.279

Low

1102639

INSY1
Inhibitory synaptic factor 1

1

0

High-throughput

0.279

Low

1328961

STX8
Syntaxin-8

1

0

High-throughput

0.279

Low

282370

NEBL
Nebulette

1

0

Small-scale

0.269

Low

942380

DLG4
Disks large homolog 4

1

0

Small-scale

0.269

Low

1328964

SNX9
Sorting nexin-9

1

0

Small-scale

0.269

Low

562666

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

0

Small-scale

0.249

Low

1136545

SPD2A
SH3 and PX domain-containing protein 2A

1

0

Small-scale

0.249

Low

473921

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024