HitPredict

Interactor 1: XPO1 (O14980)
Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog)
Gene: XPO1

Interactor 2: SRSF5 (Q13243)
Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5)
Gene: SRSF5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	26673895
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~Xpo1
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1071 Hs			1 272
+	Hs
		172735 XPO1_HUMAN (1-1071): 0: 1022: 100.00		SRSF1_HUMAN (2-170): 6.58e-57: 184: 43.68
+	Hs
		172770 XPO1_HUMAN (1-1071): 0: 1022: 100.00		SRSF6_HUMAN (5-184): 1.34e-48: 165: 61.96
+	Xl
		1237707 Q6NS03_XENLA (1-1071): 0: 1007: 97.01		Q7ZWX7_XENLA (4-82): 2.02e-29: 111: 42.68
+	Hs
		173306 XPO1_HUMAN (1-1071): 0: 1022: 100.00		RBM4_HUMAN (3-122): 6.75e-17: 81.3: 22.50
+	Hs
		172774 XPO1_HUMAN (1-1071): 0: 1022: 100.00		PABP4_HUMAN (104-189): 2.67e-16: 80.1: 21.98
+	Hs
		172884 XPO1_HUMAN (1-1071): 0: 1022: 100.00		PAP1L_HUMAN (105-189): 4.87e-16: 79.4: 16.67
+	Hs
		172438 XPO1_HUMAN (1-1071): 0: 1022: 100.00		PABP1_HUMAN (98-189): 8.49e-16: 79: 18.56
+	Hs
		172707 XPO1_HUMAN (1-1071): 0: 1022: 100.00		TIAR_HUMAN (3-103): 2.99e-12: 67.8: 14.56
+	Xl
		1237786 Q6NS03_XENLA (1-1071): 0: 1007: 97.01		EPABA_XENLA (105-189): 2.08e-14: 74.7: 17.78
+	Sc
		403399 XPO1_YEAST (14-1067): 0: 848: 46.08		PABP_YEAST (86-192): 6.13e-15: 76.3: 19.64
+	Mm
		1189646 XPO7_MOUSE (23-1013): 5.45e-120: 397: 13.01		SRSF6_MOUSE (5-184): 3.35e-58: 190: 61.96
+	Mm
		1243946 XPO7_MOUSE (23-1013): 5.45e-120: 397: 13.01		SRSF1_MOUSE (2-170): 6.58e-57: 184: 43.68
+	Mm
		1423954 XPO7_MOUSE (23-1013): 5.45e-120: 397: 13.01		SRSF9_MOUSE (2-211): 1.95e-54: 177: 34.42
+	Mm
		204689 XPO7_MOUSE (23-1013): 5.45e-120: 397: 13.01		SRSF5_MOUSE (1-179): 5.39e-54: 177: 100.00
+	Mm
		1354023 XPO7_MOUSE (23-1013): 5.45e-120: 397: 13.01		SRSF4_MOUSE (5-267): 3.3e-46: 163: 53.76
+	At
		198811 MOS14_ARATH (26-1002): 6.4e-104: 350: 13.35		SR34_ARATH (6-268): 3.4e-47: 161: 31.90
+	Dm
		688434 Q9VQG0_DROME (24-1023): 1.79e-89: 309: 12.89		SRR55_DROME (1-179): 1.67e-56: 187: 58.64
+	At
		1020248 MOS14_ARATH (26-1002): 6.4e-104: 350: 13.35		SRS31_ARATH (6-267): 1.99e-40: 142: 28.36
+	Mm
		1016705 XPO7_MOUSE (23-1013): 5.45e-120: 397: 13.01		SRSF3_MOUSE (4-78): 1.86e-11: 62.8: 47.56
+	At
		1298926 MOS14_ARATH (26-1002): 6.4e-104: 350: 13.35		RSZ33_ARATH (5-80): 2.25e-13: 70.5: 51.32