HitPredict

Interactor 1: CASC3 (O15234)
Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz)
Gene: CASC3

Interactor 2: SRSF3 (P84103)
Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3)
Gene: SRSF3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0006406 - mRNA export from nucleus GO:0016607 - nuclear speck
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 703 Hs			1 164
+	Hs
		172864 CASC3_HUMAN (1-703): 3.04e-79: 269: 100.00		SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35
+	Hs
		172850 CASC3_HUMAN (1-703): 3.04e-79: 269: 100.00		SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65
+	Hs
		172817 CASC3_HUMAN (1-703): 3.04e-79: 269: 100.00		PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77
+	Hs
		172856 CASC3_HUMAN (1-703): 3.04e-79: 269: 100.00		SRSF6_HUMAN (11-88): 3.86e-16: 75.8: 47.44
+	Hs
		992772 MDC1_HUMAN (26-703): 5.64e-39: 157: 9.51		SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65
+	Hs
		1028547 MDC1_HUMAN (26-703): 5.64e-39: 157: 9.51		SRSF9_HUMAN (9-82): 1.91e-19: 83.2: 40.79
+	Hs
		516595 KMT2C_HUMAN (265-696): 9.73e-14: 77.5: 13.27		PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77
+	Hs
		1031402 ATX2L_HUMAN (106-703): 3.11e-11: 69.1: 10.52		PABP4_HUMAN (5-91): 1.61e-21: 91.9: 26.09
+	Hs
		516606 ATX2L_HUMAN (106-703): 3.11e-11: 69.1: 10.52		PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77