HitPredict

Interactor 1: TRI18 (O15344)
E3 ubiquitin-protein ligase Midline-1 (EC 2.3.2.27) (Midin) (Putative transcription factor XPRF) (RING finger protein 59) (RING finger protein Midline-1) (RING-type E3 ubiquitin transferase Midline-1) (Tripartite motif-containing protein 18)
Gene: MID1

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	unassigned1853
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Pkinase~fn3
Common GO terms	GO:0005737 - cytoplasm GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0008017 - microtubule binding GO:0042803 - protein homodimerization activity
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 667 Hs			1 2527
+	Hs
		1130704 TRIM1_HUMAN (1-665): 4.96e-164: 490: 72.81		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		536867 TRI27_HUMAN (90-433): 1.46e-30: 128: 14.08		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		734646 TRI23_HUMAN (8-252): 7.45e-19: 92.4: 25.88		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		782800 TRI67_HUMAN (54-660): 7.29e-91: 301: 24.39		CSK_HUMAN (1722-2140): 2.25e-102: 339: 20.74
+	Hs
		1172297 TRI67_HUMAN (54-660): 7.29e-91: 301: 24.39		SHOC2_HUMAN (944-1353): 1.23e-60: 222: 22.27
+	Hs
		201335 TRI25_HUMAN (4-656): 9.25e-108: 341: 22.80		M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83
+	Hs
		201334 TRI14_HUMAN (152-652): 3.33e-73: 244: 18.90		M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83
+	Hs
		201425 TRIM8_HUMAN (4-405): 5.33e-72: 244: 20.10		M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83
+	Hs
		537133 TRI27_HUMAN (90-433): 1.46e-30: 128: 14.08		SHOC2_HUMAN (944-1353): 1.23e-60: 222: 22.27
+	Hs
		201439 TRI45_HUMAN (10-487): 4.12e-69: 237: 18.18		M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83
+	Hs
		1223394 TRI22_HUMAN (85-414): 3.62e-30: 126: 16.96		MFHA1_HUMAN (838-1119): 1.5e-30: 134: 16.95
+	Hs
		201197 TRI27_HUMAN (90-433): 1.46e-30: 128: 14.08		M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83
+	Hs
		201427 TRIM5_HUMAN (92-376): 2.38e-28: 121: 17.24		M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83
+	Hs
		201245 TRI23_HUMAN (8-252): 7.45e-19: 92.4: 25.88		M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83
+	Hs
		135003 TRI38_HUMAN (2-249): 1.78e-15: 81.3: 16.94		M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83