Protein: CFT1
Protein CFT1 (Cleavage factor two protein 1)

Gene: CFT1
Organism: Saccharomyces cerevisiae S288C
Interactions: 66
UniProt ID: Q06632

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex
GO:0006369 - termination of RNA polymerase II transcription

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

843181

PFS2
Polyadenylation factor subunit 2

8

20

Small-scale

0.968

High

1053587

YTH1
mRNA 3'-end-processing protein YTH1

6

4

Small-scale

0.943

High

781160

SWD2
COMPASS component SWD2

5

16

Small-scale

0.925

High

671430

RNA14
mRNA 3'-end-processing protein RNA14

4

5

Small-scale

0.906

High

1030139

PTA1
Pre-tRNA-processing protein PTA1

10

2

Small-scale

0.752

High

776499

MPE1
Protein MPE1

8

1

Small-scale

0.752

High

743294

PP12
Serine/threonine-protein phosphatase PP1-2

7

2

Small-scale

0.748

High

853591

FIP1
Pre-mRNA polyadenylation factor FIP1

7

2

Small-scale

0.744

High

1056342

CFT2
Cleavage factor two protein 2

6

8

Small-scale

0.735

High

712941

PAP
Poly(A) polymerase

6

4

Small-scale

0.734

High

1054424

YSH1
Endoribonuclease YSH1

5

8

Small-scale

0.714

High

837288

REF2
RNA end formation protein 2

6

0

Small-scale

0.701

High

794004

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

14

High-throughput

0.691

High

814990

PTI1
Protein PTI1

5

0

Small-scale

0.684

High

402124

RPB1
DNA-directed RNA polymerase II subunit RPB1

3

3

Small-scale

0.674

High

921030

SSU72
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

3

2

Small-scale

0.656

High

656635

KC11
Casein kinase I homolog 1

1

1

Small-scale

0.647

High

708290

TF2B
Transcription initiation factor IIB

3

1

Small-scale

0.640

High

1056341

CLP1
mRNA cleavage and polyadenylation factor CLP1

2

1

Small-scale

0.629

High

364761

CDK1
Cyclin-dependent kinase 1

1

2

High-throughput

0.618

High

671456

RNA15
mRNA 3'-end-processing protein RNA15

1

6

Small-scale

0.618

High

741136

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

5

High-throughput

0.618

High

1056345

YRA1
RNA annealing protein YRA1

1

3

High-throughput

0.618

High

751908

TFC4
Transcription factor tau 131 kDa subunit

2

1

Small-scale

0.595

High

448813

SNF1
Carbon catabolite-derepressing protein kinase

1

0

Small-scale

0.586

High

811241

PCF11
Protein PCF11

2

2

Small-scale

0.584

High

598922

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

2

0

High-throughput

0.563

High

527782

HSP72
Heat shock protein SSA2

2

6

High-throughput

0.552

High

819899

SSB2
Ribosome-associated molecular chaperone SSB2

2

7

High-throughput

0.552

High

393393

HSP82
ATP-dependent molecular chaperone HSP82

1

3

High-throughput

0.541

High

525273

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.536

High

546420

SSB1
Ribosome-associated molecular chaperone SSB1

1

7

High-throughput

0.536

High

722287

XPO1
Exportin-1

1

1

High-throughput

0.536

High

763029

SPT7
SAGA complex subunit SPT7

1

13

High-throughput

0.536

High

1050598

ARP9
Actin-like protein ARP9

1

2

High-throughput

0.515

High

433083

RL6B
Large ribosomal subunit protein eL6B

1

0

High-throughput

0.513

High

594586

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.479

High

757543

NCBP1
Nuclear cap-binding protein complex subunit 1

1

4

High-throughput

0.479

High

1018329

CTR9
RNA polymerase-associated protein CTR9

1

1

Small-scale

0.479

High

1044772

SCC2
Sister chromatid cohesion protein 2

1

3

High-throughput

0.479

High

1056344

SCC1
Sister chromatid cohesion protein 1

1

3

High-throughput

0.479

High

1056346

RIO1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

655644

TAF2
Transcription initiation factor TFIID subunit 2

1

0

High-throughput

0.458

High

735182

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

864884

MAD3
Spindle assembly checkpoint component MAD3

1

0

Small-scale

0.458

High

432710

RL7A
Large ribosomal subunit protein uL30A

1

1

High-throughput

0.445

High

580126

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.445

High

671161

SIS1
Protein SIS1

1

1

High-throughput

0.445

High

742484

HSP7F
Heat shock protein homolog SSE1

1

8

High-throughput

0.445

High

804485

SSZ1
Ribosome-associated complex subunit SSZ1

1

4

High-throughput

0.445

High

816424

HSP7E
Heat shock protein SSC3, mitochondrial

1

3

High-throughput

0.445

High

1056347

RL7B
Large ribosomal subunit protein uL30B

1

1

High-throughput

0.445

High

676384

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.426

High

712676

RL8B
Large ribosomal subunit protein eL8B

1

0

High-throughput

0.426

High

820968

RL13B
Large ribosomal subunit protein eL13B

1

0

High-throughput

0.426

High

885094

RL4B
Large ribosomal subunit protein uL4B

1

0

High-throughput

0.426

High

383910

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.407

High

433301

RL17A
Large ribosomal subunit protein uL22A

1

1

High-throughput

0.407

High

570310

RS17B
Small ribosomal subunit protein eS17B

1

2

High-throughput

0.407

High

863885

RL17B
Large ribosomal subunit protein uL22B

1

1

High-throughput

0.407

High

1056348

CRM2
Homeostatic regulator of DAG

1

0

High-throughput

0.269

Low

1056343

APC9
Anaphase-promoting complex subunit 9

1

0

High-throughput

0.238

Low

835896

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.232

Low

865083

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.232

Low

871567

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.232

Low

1056349

HSP42
Heat shock protein 42

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025