HitPredict

Interactor 1: GPR37 (O15354)
Prosaposin receptor GPR37 (Endothelin B receptor-like protein 1) (ETBR-LP-1) (G-protein coupled receptor 37) (Parkin-associated endothelin receptor-like receptor) (PAELR)
Gene: GPR37

Interactor 2: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.75 0.60 0.672

The method score is based on:

Property Details
Experiments 11439185, 12150907, 14579121
Identification Methods two hybrid, affinity chromatography technology, pull down, enzymatic study
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000151 - ubiquitin ligase complex
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum
GO:0030165 - PDZ domain binding
GO:0030544 - Hsp70 protein binding
and 2 others

more...
Homologous interactions 6

Homologous interactions

Color coding for hit scores

1 613
Hs

1 465
+ Hs
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+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024