HitPredict

Interactor 1: SHIP2 (O15357)
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)
Gene: INPPL1

Interactor 2: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	17314030, 19531213
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0006897 - endocytosis GO:0006915 - apoptotic process GO:0007015 - actin filament organization GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1258 Hs			1 665
+	Hs
		176509 SHIP2_HUMAN (1-1258): 0: 968: 100.00		CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22
+	Hs
		176424 SHIP2_HUMAN (1-1258): 0: 968: 100.00		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		1271562 SHIP1_HUMAN (21-1197): 0: 699: 40.63		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Mm
		1246940 SHIP1_MOUSE (19-1216): 0: 706: 39.46		SH3K1_MOUSE (1-665): 4.53e-118: 370: 87.59
+	Hs
		176448 SHIP2_HUMAN (1-1258): 0: 968: 100.00		ITSN1_HUMAN (68-454): 2.48e-21: 101: 14.01
+	Mm
		1159873 SHIP2_MOUSE (1-1258): 0: 956: 95.79		ITSN1_MOUSE (120-519): 1.9e-19: 95.5: 14.11
+	Hs
		176326 SHIP2_HUMAN (1-1258): 0: 968: 100.00		VINEX_HUMAN (67-445): 2.37e-15: 81.7: 19.82
+	Mm
		1159872 SHIP2_MOUSE (1-1258): 0: 956: 95.79		VINEX_MOUSE (78-383): 4.64e-10: 64.7: 18.12
+	Hs
		1271571 SHIP1_HUMAN (21-1197): 0: 699: 40.63		CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22
+	Hs
		203241 SYNJ1_HUMAN (186-1224): 0: 604: 16.35		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Mm
		1141165 SHIP1_MOUSE (19-1216): 0: 706: 39.46		GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91
+	Hs
		557759 SHIP1_HUMAN (21-1197): 0: 699: 40.63		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		924742 SHIP1_HUMAN (21-1197): 0: 699: 40.63		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		203208 SYNJ1_HUMAN (186-1224): 0: 604: 16.35		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		203218 SYNJ1_HUMAN (186-1224): 0: 604: 16.35		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		203228 SYNJ1_HUMAN (186-1224): 0: 604: 16.35		ITSN1_HUMAN (68-454): 2.48e-21: 101: 14.01
+	Hs
		203191 SYNJ1_HUMAN (186-1224): 0: 604: 16.35		VINEX_HUMAN (67-445): 2.37e-15: 81.7: 19.82
+	Hs
		203192 SYNJ1_HUMAN (186-1224): 0: 604: 16.35		SRBS2_HUMAN (3-155): 4.65e-11: 68.2: 30.86
+	Hs
		203230 SYNJ1_HUMAN (186-1224): 0: 604: 16.35		SH319_HUMAN (164-469): 4.12e-09: 61.9: 13.31
+	Ce
		105281 SYNJ_CAEEL (172-984): 3.68e-168: 531: 17.66		Q9U2T9_CAEEL (142-349): 4.59e-14: 78.1: 18.48