HitPredict

Interactor 1: EIF3H (O15372)
Eukaryotic translation initiation factor 3 subunit H (eIF3h) (Eukaryotic translation initiation factor 3 subunit 3) (eIF-3-gamma) (eIF3 p40 subunit)
Gene: EIF3H

Interactor 2: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	32929329, 35987950, 35256949
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	JAB~ubiquitin
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 352 Hs			1 465
+	Hs
		124687 EIF3F_HUMAN (13-334): 2.26e-72: 230: 17.39		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		228258 CSN5_HUMAN (16-310): 1.83e-72: 230: 17.26		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		130654 PSDE_HUMAN (28-290): 2.44e-66: 213: 21.75		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		227878 CSN6_HUMAN (8-334): 4.21e-64: 208: 15.27		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		226913 PSMD7_HUMAN (35-329): 2.16e-61: 201: 15.23		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		176926 EIF3H_HUMAN (1-352): 6.57e-120: 351: 100.00		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	At
		1091965 EIF3H_ARATH (17-349): 1.11e-99: 299: 39.58		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	Hs
		130704 PSDE_HUMAN (28-290): 2.44e-66: 213: 21.75		UBB_HUMAN (1-234): 1.14e-59: 197: 17.92
+	Sc
		477336 RPN11_YEAST (16-285): 1.36e-61: 201: 22.41		UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72
+	Sc
		477501 CSN5_YEAST (38-295): 2.28e-50: 175: 21.01		UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72
+	At
		1091793 CSN5A_ARATH (16-313): 1.53e-73: 233: 16.99		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	Hs
		124740 EIF3F_HUMAN (13-334): 2.26e-72: 230: 17.39		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	Hs
		476142 CSN5_HUMAN (16-310): 1.83e-72: 230: 17.26		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	At
		1092172 PSDE_ARATH (18-291): 9.64e-71: 224: 19.60		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	Hs
		130705 PSDE_HUMAN (28-290): 2.44e-66: 213: 21.75		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	At
		1091969 PSD7B_ARATH (27-329): 3.45e-66: 213: 17.10		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	At
		188941 PSD7A_ARATH (27-329): 5.11e-66: 212: 16.77		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	Hs
		475966 CSN6_HUMAN (8-334): 4.21e-64: 208: 15.27		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	Hs
		475500 PSMD7_HUMAN (35-329): 2.16e-61: 201: 15.23		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	At
		137953 EIF3F_ARATH (25-267): 3.54e-53: 178: 18.44		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17