HitPredict

Interactor 1: HDAC3 (O15379)
Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45)
Gene: HDAC3

Interactor 2: DDX5 (P17844)
Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68)
Gene: DDX5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	20663877, 19995069
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol and 1 others more... GO:0019899 - enzyme binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 428 Hs			1 614
+	Hs
		571439 HDAC1_HUMAN (3-385): 0: 588: 62.92		DDX5_HUMAN (1-614): 0: 624: 100.00
+	Hs
		571532 HDAC2_HUMAN (3-422): 0: 580: 58.63		DDX5_HUMAN (1-614): 0: 624: 100.00
+	Hs
		177348 HDAC3_HUMAN (1-428): 0: 600: 100.00		DDX17_HUMAN (30-612): 0: 534: 66.83
+	Hs
		1038593 HDAC1_HUMAN (3-385): 0: 588: 62.92		DDX17_HUMAN (30-612): 0: 534: 66.83
+	Hs
		1270350 HDAC2_HUMAN (3-422): 0: 580: 58.63		DDX17_HUMAN (30-612): 0: 534: 66.83
+	Hs
		134143 HDAC2_HUMAN (3-422): 0: 580: 58.63		DDX3X_HUMAN (2-556): 9.8e-147: 441: 35.52
+	Hs
		571620 HDAC6_HUMAN (5-320): 3.49e-103: 333: 23.24		DDX5_HUMAN (1-614): 0: 624: 100.00
+	Hs
		1271686 HDAC6_HUMAN (5-320): 3.49e-103: 333: 23.24		DDX17_HUMAN (30-612): 0: 534: 66.83
+	Hs
		134234 HDAC6_HUMAN (5-320): 3.49e-103: 333: 23.24		DDX3X_HUMAN (2-556): 9.8e-147: 441: 35.52