HitPredict

Interactor 1: HDAC3 (O15379)
Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45)
Gene: HDAC3

Interactor 2: NR2C2 (P49116)
Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4)
Gene: NR2C2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	12943985, 21670149
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 428 Hs			1 596
+	Hs
		823977 HDAC1_HUMAN (3-385): 0: 588: 62.92		NR2C2_HUMAN (1-596): 0: 527: 100.00
+	Hs
		177183 HDAC3_HUMAN (1-428): 0: 600: 100.00		NR2C1_HUMAN (21-596): 1.19e-132: 402: 60.50
+	Hs
		525310 HDAC1_HUMAN (3-385): 0: 588: 62.92		NR2C1_HUMAN (21-596): 1.19e-132: 402: 60.50
+	Hs
		525327 HDAC2_HUMAN (3-422): 0: 580: 58.63		NR2C1_HUMAN (21-596): 1.19e-132: 402: 60.50
+	Mm
		292408 HDAC3_MOUSE (1-428): 0: 601: 99.77		RORA_MOUSE (60-583): 2.49e-88: 285: 20.83
+	Hs
		177193 HDAC3_HUMAN (1-428): 0: 600: 100.00		NR1D1_HUMAN (23-566): 1.48e-87: 285: 18.64
+	Hs
		1038387 HDAC1_HUMAN (3-385): 0: 588: 62.92		NR1D2_HUMAN (89-566): 4.51e-92: 296: 18.59
+	Hs
		1030585 HDAC1_HUMAN (3-385): 0: 588: 62.92		STF1_HUMAN (110-583): 1.35e-87: 281: 21.47
+	Hs
		846410 HDAC1_HUMAN (3-385): 0: 588: 62.92		RORG_HUMAN (94-584): 2.21e-86: 280: 20.81
+	Hs
		177191 HDAC3_HUMAN (1-428): 0: 600: 100.00		RXRA_HUMAN (1-291): 9.13e-62: 213: 26.82
+	Mm
		140236 HDAC1_MOUSE (3-385): 0: 588: 62.92		RXRA_MOUSE (16-291): 4.35e-62: 214: 26.83
+	Hs
		177223 HDAC3_HUMAN (1-428): 0: 600: 100.00		HNF4A_HUMAN (88-274): 1.46e-51: 186: 33.85
+	Hs
		177412 HDAC3_HUMAN (1-428): 0: 600: 100.00		NR2E1_HUMAN (116-324): 6.69e-47: 171: 29.28
+	Mm
		292417 HDAC3_MOUSE (1-428): 0: 601: 99.77		NR2E1_MOUSE (116-324): 1.31e-46: 170: 29.28
+	Hs
		1038843 HDAC1_HUMAN (3-385): 0: 588: 62.92		NR2E1_HUMAN (116-324): 6.69e-47: 171: 29.28
+	Hs
		622790 HDAC1_HUMAN (3-385): 0: 588: 62.92		COT2_HUMAN (106-277): 8.49e-46: 168: 40.33
+	Hs
		177175 HDAC3_HUMAN (1-428): 0: 600: 100.00		RARA_HUMAN (66-191): 1.29e-27: 118: 44.53
+	Hs
		177299 HDAC3_HUMAN (1-428): 0: 600: 100.00		Q15156_HUMAN (92-191): 6.42e-26: 115: 50.98
+	Hs
		487964 HDAC1_HUMAN (3-385): 0: 588: 62.92		RARA_HUMAN (66-191): 1.29e-27: 118: 44.53
+	Hs
		488000 HDAC2_HUMAN (3-422): 0: 580: 58.63		RARA_HUMAN (66-191): 1.29e-27: 118: 44.53