Protein: ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK)

Gene: ANR28, ANKRD28
Organism: Homo sapiens
Interactions: 229
UniProt ID: O15084

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

177189

PLK1
Serine/threonine-protein kinase PLK1

6

7

Small-scale

0.947

High

177318

PLK2
Serine/threonine-protein kinase PLK2

3

7

High-throughput

0.861

High

177180

BRCA1
Breast cancer type 1 susceptibility protein

3

3

Small-scale

0.857

High

177261

ANR44
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B

6

12

High-throughput

0.845

High

177228

KCC4
Calcium/calmodulin-dependent protein kinase type IV

2

1

High-throughput

0.811

High

177204

NOTC2
Neurogenic locus notch homolog protein 2

2

16

High-throughput

0.793

High

177322

ANFY1
Rabankyrin-5

2

13

High-throughput

0.793

High

143502

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

8

3

Small-scale

0.754

High

177183

MK08
Mitogen-activated protein kinase 8

2

5

High-throughput

0.754

High

177325

TBK1
Serine/threonine-protein kinase TBK1

2

2

High-throughput

0.754

High

177176

MK01
Mitogen-activated protein kinase 1

2

2

High-throughput

0.737

High

177150

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

5

14

Small-scale

0.723

High

177286

AP2M1
AP-2 complex subunit mu

5

3

High-throughput

0.722

High

177222

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

5

6

High-throughput

0.712

High

177135

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

12

High-throughput

0.698

High

177156

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

1

13

High-throughput

0.698

High

177170

BCL3
B-cell lymphoma 3 protein

1

17

High-throughput

0.698

High

177203

ANK2
Ankyrin-2

1

13

High-throughput

0.698

High

177277

TITIN
Titin

1

5

High-throughput

0.698

High

177291

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

17

High-throughput

0.698

High

177304

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

18

High-throughput

0.698

High

177307

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

1

13

High-throughput

0.698

High

177336

NOTC3
Neurogenic locus notch homolog protein 3

1

16

High-throughput

0.698

High

177143

MYPT2
Protein phosphatase 1 regulatory subunit 12B

1

17

High-throughput

0.691

High

177198

PRKDC
DNA-dependent protein kinase catalytic subunit

1

1

High-throughput

0.691

High

177201

CDKL1
Cyclin-dependent kinase-like 1

1

1

High-throughput

0.691

High

177246

UBP49
Ubiquitin carboxyl-terminal hydrolase 49

1

6

High-throughput

0.691

High

177272

BRSK1
Serine/threonine-protein kinase BRSK1

1

1

High-throughput

0.691

High

177317

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

12

High-throughput

0.691

High

140058

SDCB1
Syntenin-1

4

9

High-throughput

0.691

High

177282

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

4

4

High-throughput

0.691

High

177338

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

3

9

Small-scale

0.675

High

177280

ARHG2
Rho guanine nucleotide exchange factor 2

3

9

Small-scale

0.675

High

177235

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

3

10

Small-scale

0.671

High

177164

HXC4
Homeobox protein Hox-C4

3

20

High-throughput

0.667

High

177181

CCNF
Cyclin-F

1

4

High-throughput

0.665

High

177302

SH3G3
Endophilin-A3

2

2

High-throughput

0.659

High

177299

DCR1C
Protein artemis

3

1

High-throughput

0.656

High

177295

SNX18
Sorting nexin-18

1

6

High-throughput

0.640

High

177257

TRM2A
tRNA

2

5

High-throughput

0.628

High

177188

MYOM1
Myomesin-1

1

4

High-throughput

0.625

High

177330

ANR50
Ankyrin repeat domain-containing protein 50

1

14

High-throughput

0.625

High

177340

ANR26
Ankyrin repeat domain-containing protein 26

1

17

High-throughput

0.625

High

177247

MOB1B
MOB kinase activator 1B

2

4

High-throughput

0.621

High

177310

MOB1A
MOB kinase activator 1A

2

4

High-throughput

0.621

High

177171

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

1

High-throughput

0.621

High

177263

ANR52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

1

13

High-throughput

0.618

High

58687

PTPC1
Protein tyrosine phosphatase domain-containing protein 1

1

8

High-throughput

0.618

High

122671

KIF2A
Kinesin-like protein KIF2A

1

6

High-throughput

0.618

High

127742

IKBE
NF-kappa-B inhibitor epsilon

1

15

High-throughput

0.618

High

177152

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.618

High

177155

UBR5
E3 ubiquitin-protein ligase UBR5

1

9

High-throughput

0.618

High

177158

LATS1
Serine/threonine-protein kinase LATS1

1

2

High-throughput

0.618

High

177172

APC
Adenomatous polyposis coli protein

1

18

High-throughput

0.618

High

177184

GSK3A
Glycogen synthase kinase-3 alpha

1

8

High-throughput

0.618

High

177185

GSK3B
Glycogen synthase kinase-3 beta

1

8

High-throughput

0.618

High

177187

NEK4
Serine/threonine-protein kinase Nek4

1

6

High-throughput

0.618

High

177209

ANK3
Ankyrin-3

1

13

High-throughput

0.618

High

177215

CUL3
Cullin-3

1

9

High-throughput

0.618

High

177216

DOCK1
Dedicator of cytokinesis protein 1

1

7

Small-scale

0.618

High

177224

NFAC4
Nuclear factor of activated T-cells, cytoplasmic 4

1

4

High-throughput

0.618

High

177227

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.618

High

177306

DUS15
Dual specificity protein phosphatase 15

1

5

High-throughput

0.618

High

177268

ZNRF2
E3 ubiquitin-protein ligase ZNRF2

2

2

Small-scale

0.611

High

177231

FX4L6
Forkhead box protein D4-like 6

3

6

High-throughput

0.609

High

177294

YTDC1
YTH domain-containing protein 1

2

6

High-throughput

0.606

High

177313

FBX6
F-box only protein 6

1

0

High-throughput

0.586

High

177138

EIF3D
Eukaryotic translation initiation factor 3 subunit D

2

0

High-throughput

0.580

High

177207

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

177270

G45IP
Large ribosomal subunit protein mL64

2

0

High-throughput

0.580

High

177303

THAP7
THAP domain-containing protein 7

2

0

High-throughput

0.580

High

69745

ZN785
Zinc finger protein 785

2

3

High-throughput

0.574

High

177210

GRB10
Growth factor receptor-bound protein 10

2

7

High-throughput

0.571

High

177273

KCNV2
Potassium voltage-gated channel subfamily V member 2

2

6

High-throughput

0.553

High

177208

EPS8
Epidermal growth factor receptor kinase substrate 8

1

4

High-throughput

0.553

High

177244

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.553

High

177284

ARL8A
ADP-ribosylation factor-like protein 8A

1

2

High-throughput

0.553

High

177297

RB40C
Ras-related protein Rab-40C

1

5

Small-scale

0.553

High

177326

DS13B
Dual specificity protein phosphatase 13B

1

6

High-throughput

0.553

High

177331

NEB1
Neurabin-1

1

11

High-throughput

0.553

High

177333

HECD1
E3 ubiquitin-protein ligase HECTD1

1

8

High-throughput

0.553

High

177226

PGFRL
Platelet-derived growth factor receptor-like protein

2

5

High-throughput

0.549

High

177140

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

6

High-throughput

0.541

High

177192

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

6

High-throughput

0.541

High

177146

CC14B
Dual specificity protein phosphatase CDC14B

1

8

High-throughput

0.536

High

177154

AP2A2
AP-2 complex subunit alpha-2

1

2

High-throughput

0.536

High

177166

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.536

High

177178

HXA7
Homeobox protein Hox-A7

1

20

High-throughput

0.536

High

177199

FOXK1
Forkhead box protein K1

1

6

High-throughput

0.536

High

177202

FOXK2
Forkhead box protein K2

1

6

High-throughput

0.536

High

177220

TTLL4
Tubulin monoglutamylase TTLL4

1

1

High-throughput

0.536

High

177240

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

2

High-throughput

0.536

High

177249

PXK
PX domain-containing protein kinase-like protein

1

2

High-throughput

0.536

High

177314

DISC1
Disrupted in schizophrenia 1 protein

1

4

High-throughput

0.536

High

177328

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

5

High-throughput

0.536

High

177342

GAB2
GRB2-associated-binding protein 2

1

4

High-throughput

0.536

High

177174

EF1G
Elongation factor 1-gamma

1

0

High-throughput

0.518

High

177296

TGS1
Trimethylguanosine synthase

1

0

High-throughput

0.518

High

177218

RCN2
Reticulocalbin-2

1

0

High-throughput

0.517

High

177147

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.514

High

177139

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

0

High-throughput

0.513

High

177335

AKP8L
A-kinase anchor protein 8-like

1

0

High-throughput

0.513

High

177290

Z512B
Zinc finger protein 512B

1

5

High-throughput

0.508

High

177345

RNF11
RING finger protein 11

1

2

High-throughput

0.494

High

177137

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.489

High

177219

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

1

1

High-throughput

0.489

High

177223

ICAM4
Intercellular adhesion molecule 4

1

2

High-throughput

0.489

High

177229

INF2
Inverted formin-2

1

2

High-throughput

0.489

High

177259

ZN276
Zinc finger protein 276

1

1

High-throughput

0.489

High

177279

FGF14
Fibroblast growth factor 14

1

14

High-throughput

0.489

High

177300

IMP2L
Mitochondrial inner membrane protease subunit 2

1

3

High-throughput

0.489

High

177347

GPR45
Probable G-protein coupled receptor 45

1

2

High-throughput

0.489

High

122446

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

1

1

High-throughput

0.479

High

174852

SC16A
Protein transport protein Sec16A

1

2

High-throughput

0.479

High

177144

KDM1A
Lysine-specific histone demethylase 1A

1

4

High-throughput

0.479

High

177145

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

6

High-throughput

0.479

High

177153

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

177159

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.479

High

177162

K2C8
Keratin, type II cytoskeletal 8

1

8

High-throughput

0.479

High

177163

PROF1
Profilin-1

1

3

High-throughput

0.479

High

177168

EZRI
Ezrin

1

10

High-throughput

0.479

High

177169

NUCL
Nucleolin

1

2

Small-scale

0.479

High

177173

DNJB1
DnaJ homolog subfamily B member 1

1

3

High-throughput

0.479

High

177175

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.479

High

177179

CTNA1
Catenin alpha-1

1

2

High-throughput

0.479

High

177182

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

4

High-throughput

0.479

High

177186

VASP
Vasodilator-stimulated phosphoprotein

1

2

High-throughput

0.479

High

177193

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

177194

AP2B1
AP-2 complex subunit beta

1

3

High-throughput

0.479

High

177195

1433Z
14-3-3 protein zeta/delta

1

14

High-throughput

0.479

High

177206

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

16

High-throughput

0.479

High

177211

HDAC1
Histone deacetylase 1

1

6

High-throughput

0.479

High

177213

IRF5
Interferon regulatory factor 5

1

3

High-throughput

0.479

High

177214

MTMR3
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3

1

2

High-throughput

0.479

High

177217

DCTN1
Dynactin subunit 1

1

6

High-throughput

0.479

High

177221

SMC1A
Structural maintenance of chromosomes protein 1A

1

4

High-throughput

0.479

High

177230

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

177233

AMOT
Angiomotin

1

14

High-throughput

0.479

High

177234

ODFP2
Outer dense fiber protein 2

1

7

High-throughput

0.479

High

177236

CE162
Centrosomal protein of 162 kDa

1

12

High-throughput

0.479

High

177237

CP135
Centrosomal protein of 135 kDa

1

5

High-throughput

0.479

High

177238

FTM
Protein fantom

1

10

High-throughput

0.479

High

177239

VIR
Protein virilizer homolog

1

3

High-throughput

0.479

High

177248

CNTRL
Centriolin

1

8

High-throughput

0.479

High

177250

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.479

High

177251

LCA5
Lebercilin

1

7

High-throughput

0.479

High

177260

CGAS
Cyclic GMP-AMP synthase

1

1

High-throughput

0.479

High

177266

FBX22
F-box only protein 22

1

2

High-throughput

0.479

High

177267

NUP43
Nucleoporin Nup43

1

5

High-throughput

0.479

High

177274

FBF1
Fas-binding factor 1

1

11

High-throughput

0.479

High

177275

TRI41
E3 ubiquitin-protein ligase TRIM41

1

4

High-throughput

0.479

High

177278

GOGA1
Golgin subfamily A member 1

1

10

High-throughput

0.479

High

177283

PF21A
PHD finger protein 21A

1

7

High-throughput

0.479

High

177289

LRCH3
DISP complex protein LRCH3

1

3

High-throughput

0.479

High

177292

SNX27
Sorting nexin-27

1

11

High-throughput

0.479

High

177298

NEB2
Neurabin-2

1

12

High-throughput

0.479

High

177301

DNJC2
DnaJ homolog subfamily C member 2

1

5

High-throughput

0.479

High

177305

CEP44
Centrosomal protein of 44 kDa

1

1

High-throughput

0.479

High

177309

EGLN3
Prolyl hydroxylase EGLN3

1

5

High-throughput

0.479

High

177312

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

5

High-throughput

0.479

High

177324

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

177329

BAG5
BAG family molecular chaperone regulator 5

1

2

High-throughput

0.479

High

177332

PKHG1
Pleckstrin homology domain-containing family G member 1

1

8

High-throughput

0.479

High

177337

MYO6
Unconventional myosin-VI

1

6

High-throughput

0.479

High

177339

TRI33
E3 ubiquitin-protein ligase TRIM33

1

6

High-throughput

0.479

High

177343

SMC3
Structural maintenance of chromosomes protein 3

1

4

High-throughput

0.479

High

177346

MAGD1
Melanoma-associated antigen D1

1

4

High-throughput

0.479

High

177232

Q4G0R1
PIBF1 protein

1

1

High-throughput

0.470

High

177196

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.460

High

144207

ACACB
Acetyl-CoA carboxylase 2

1

0

High-throughput

0.458

High

177142

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.458

High

177177

MPIP1
M-phase inducer phosphatase 1

1

0

High-throughput

0.458

High

177191

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

177212

DCTN2
Dynactin subunit 2

1

0

High-throughput

0.458

High

177225

ABRX2
BRISC complex subunit Abraxas 2

1

0

High-throughput

0.458

High

177293

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

177319

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

171357

S27A2
Long-chain fatty acid transport protein 2

1

2

High-throughput

0.445

High

177190

AP2S1
AP-2 complex subunit sigma

1

4

High-throughput

0.445

High

177258

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.445

High

177276

PIBF1
Progesterone-induced-blocking factor 1

1

1

High-throughput

0.439

High

67743

TBKB1
TANK-binding kinase 1-binding protein 1

1

6

High-throughput

0.437

High

174458

TRI66
Tripartite motif-containing protein 66

1

6

High-throughput

0.437

High

177148

PAGE4
P antigen family member 4

1

3

High-throughput

0.437

High

177151

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.437

High

177157

BRD1
Bromodomain-containing protein 1

1

2

High-throughput

0.437

High

177161

NTRK1
High affinity nerve growth factor receptor

1

12

High-throughput

0.437

High

177197

F193A
Protein FAM193A

1

1

High-throughput

0.437

High

177200

VIGLN
Vigilin

1

5

High-throughput

0.437

High

177245

CE128
Centrosomal protein of 128 kDa

1

9

High-throughput

0.437

High

177252

HOOK3
Protein Hook homolog 3

1

16

High-throughput

0.437

High

177271

SHKB1
SH3KBP1-binding protein 1

1

10

High-throughput

0.437

High

177285

ENTR1
Endosome-associated-trafficking regulator 1

1

1

High-throughput

0.437

High

177287

BORC6
BLOC-1-related complex subunit 6

1

1

High-throughput

0.437

High

177308

PKHA4
Pleckstrin homology domain-containing family A member 4

1

13

High-throughput

0.437

High

177320

SEP10
Septin-10

1

1

High-throughput

0.437

High

177321

WHRN
Whirlin

1

10

High-throughput

0.437

High

177327

HOOK1
Protein Hook homolog 1

1

9

High-throughput

0.437

High

166215

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

4

High-throughput

0.407

High

177241

S27A4
Long-chain fatty acid transport protein 4

1

2

High-throughput

0.407

High

177242

S27A1
Long-chain fatty acid transport protein 1

1

2

High-throughput

0.407

High

177341

XCT
Cystine/glutamate transporter

1

4

High-throughput

0.407

High

177316

NECP2
Adaptin ear-binding coat-associated protein 2

3

0

High-throughput

0.347

High

177243

ZN574
Zinc finger protein 574

2

0

High-throughput

0.328

High

177254

PTH
Peptidyl-tRNA hydrolase

2

0

High-throughput

0.316

High

177256

Q8IVT4
Hypothetical MGC50722

2

0

High-throughput

0.316

High

177205

MUC24
Sialomucin core protein 24

1

0

High-throughput

0.282

High

177323

ABCF2
ATP-binding cassette sub-family F member 2

1

0

High-throughput

0.282

High

177141

TNF14
Tumor necrosis factor ligand superfamily member 14

1

0

High-throughput

0.279

Low

177149

RAMP1
Receptor activity-modifying protein 1

1

0

High-throughput

0.279

Low

177160

HG2A
HLA class II histocompatibility antigen gamma chain

1

0

High-throughput

0.279

Low

177167

DRD2
D(2) dopamine receptor

1

0

High-throughput

0.279

Low

177253

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

0

High-throughput

0.279

Low

177255

FABD
Malonyl-CoA-acyl carrier protein transacylase, mitochondrial

1

0

High-throughput

0.279

Low

177334

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.279

Low

177344

RT07
Small ribosomal subunit protein uS7m

1

0

High-throughput

0.279

Low

177136

PLCB
1-acyl-sn-glycerol-3-phosphate acyltransferase beta

1

0

High-throughput

0.251

Low

177265

TMIE
Transmembrane inner ear expressed protein

1

0

High-throughput

0.251

Low

129913

PGRC1
Membrane-associated progesterone receptor component 1

1

0

Small-scale

0.249

Low

177262

KRI1
Protein KRI1 homolog

1

0

High-throughput

0.249

Low

177264

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.249

Low

177269

RASF8
Ras association domain-containing protein 8

1

0

High-throughput

0.249

Low

177288

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

177311

Q9HCK3
KIAA1569 protein

1

0

High-throughput

0.249

Low

143717

WN10B
Protein Wnt-10b

1

0

High-throughput

0.232

Low

177165

PIP
Prolactin-inducible protein

1

0

High-throughput

0.232

Low

177281

S35B4
Nucleotide sugar transporter SLC35B4

1

0

High-throughput

0.232

Low

177315

S22AB
Solute carrier family 22 member 11

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025