HitPredict

Interactor 1: NPC1 (O15118)
NPC intracellular cholesterol transporter 1 (Niemann-Pick C1 protein)
Gene: NPC1

Interactor 2: LAMP2 (P13473)
Lysosome-associated membrane glycoprotein 2 (LAMP-2) (Lysosome-associated membrane protein 2) (CD107 antigen-like family member B) (LGP-96) (CD antigen CD107b)
Gene: LAMP2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.56 0.60 0.584

The method score is based on:

Property Details
Experiments 33144569, 34079125
Identification Methods affinity chromatography technology, proximity labelling technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005764 - lysosome
GO:0005765 - lysosomal membrane
GO:0005886 - plasma membrane
GO:0016020 - membrane
GO:0031902 - late endosome membrane
and 2 others

more...
Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 1278
Hs

1 410
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 11Aug2025