Protein: HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34)

Gene: HMDH, HMGCR
Organism: Homo sapiens
Interactions: 118
UniProt ID: P04035

Gene Ontology (top 5):
GO:0004420 - hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0005778 - peroxisomal membrane
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006695 - cholesterol biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

192419

INSI1
Insulin-induced gene 1 protein

6

3

Small-scale

0.931

High

399754

UBIA1
UbiA prenyltransferase domain-containing protein 1

2

0

Small-scale

0.783

High

399691

PTHD3
Patched domain-containing protein 3

1

4

High-throughput

0.691

High

399748

AMFR
E3 ubiquitin-protein ligase AMFR

4

12

Small-scale

0.686

High

399701

RIC3
Protein RIC-3

3

0

High-throughput

0.622

High

399753

INSI2
Insulin-induced gene 2 protein

1

3

Small-scale

0.618

High

321144

ERLN2
Erlin-2

2

5

Small-scale

0.611

High

170605

CLGN
Calmegin

2

9

High-throughput

0.601

High

399737

UN93B
Protein unc-93 homolog B1

2

1

High-throughput

0.601

High

399674

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

3

3

High-throughput

0.593

High

399654

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

2

3

High-throughput

0.584

High

399667

PI2R
Prostacyclin receptor

2

2

High-throughput

0.574

High

399688

GBRA6
Gamma-aminobutyric acid receptor subunit alpha-6

2

2

High-throughput

0.574

High

399712

AGRG5
Adhesion G-protein coupled receptor G5

2

2

High-throughput

0.574

High

399734

KCNS3
Delayed-rectifier potassium channel regulatory subunit KCNS3

2

1

High-throughput

0.574

High

399723

FAF2
FAS-associated factor 2

2

2

High-throughput

0.571

High

399673

CCR6
C-C chemokine receptor type 6

2

5

High-throughput

0.549

High

399682

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

2

7

High-throughput

0.549

High

399706

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

2

7

High-throughput

0.549

High

399658

CP19A
Aromatase

1

1

High-throughput

0.536

High

399660

CALX
Calnexin

1

9

High-throughput

0.536

High

399662

V2R
Vasopressin V2 receptor

1

1

High-throughput

0.536

High

399664

CP2CI
Cytochrome P450 2C18

1

1

High-throughput

0.536

High

399675

TERA
Transitional endoplasmic reticulum ATPase

1

2

Small-scale

0.536

High

399681

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

4

High-throughput

0.536

High

399692

TTMP
TPA-induced transmembrane protein

1

1

High-throughput

0.536

High

399704

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

12

High-throughput

0.536

High

399710

S15A3
Solute carrier family 15 member 3

2

2

High-throughput

0.521

High

399684

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.513

High

250034

ADCY9
Adenylate cyclase type 9

1

1

High-throughput

0.489

High

399663

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

3

High-throughput

0.489

High

399665

P2RY2
P2Y purinoceptor 2

1

8

High-throughput

0.489

High

399666

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

3

High-throughput

0.489

High

399678

IDD
Integral membrane protein DGCR2/IDD

1

4

High-throughput

0.489

High

399679

ACHD
Acetylcholine receptor subunit delta

1

3

High-throughput

0.489

High

399698

BTNL3
Butyrophilin-like protein 3

1

7

High-throughput

0.489

High

399715

ACV1C
Activin receptor type-1C

1

2

High-throughput

0.489

High

399738

LPAR2
Lysophosphatidic acid receptor 2

1

10

High-throughput

0.489

High

399742

EVA1B
Protein eva-1 homolog B

1

1

High-throughput

0.489

High

399750

PCDB3
Protocadherin beta-3

1

2

High-throughput

0.489

High

399751

PCDGL
Protocadherin gamma-C4

1

2

High-throughput

0.489

High

173830

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

5

High-throughput

0.479

High

399655

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.479

High

399656

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

Small-scale

0.479

High

399676

SC61B
Protein transport protein Sec61 subunit beta

1

2

High-throughput

0.479

High

399680

CKAP4
Cytoskeleton-associated protein 4

1

3

High-throughput

0.479

High

399714

RN148
RING finger protein 148

1

14

High-throughput

0.479

High

399718

RN139
E3 ubiquitin-protein ligase RNF139

1

11

Small-scale

0.479

High

399720

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

1

11

High-throughput

0.479

High

399732

SEC62
Translocation protein SEC62

1

2

High-throughput

0.479

High

399741

CC50A
Cell cycle control protein 50A

1

1

High-throughput

0.479

High

399752

SRPRB
Signal recognition particle receptor subunit beta

1

5

High-throughput

0.479

High

399755

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

1

Small-scale

0.479

High

399731

KCNKG
Potassium channel subfamily K member 16

1

0

High-throughput

0.458

High

399690

S35G1
Solute carrier family 35 member G1

1

5

High-throughput

0.445

High

71375

HECA2
HEPACAM family member 2

1

1

High-throughput

0.437

High

212365

SPIT2
Kunitz-type protease inhibitor 2

1

1

High-throughput

0.437

High

217694

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.437

High

316474

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

1

High-throughput

0.437

High

399657

LAMP1
Lysosome-associated membrane glycoprotein 1

1

2

High-throughput

0.437

High

399686

ELOB
Elongin-B

1

1

High-throughput

0.437

High

399687

EREP1
Endosomal transmembrane epsin interactor 1

1

1

High-throughput

0.437

High

399696

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

399699

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

399700

BT2A1
Butyrophilin subfamily 2 member A1

1

7

High-throughput

0.437

High

399702

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

14

High-throughput

0.437

High

399703

TM11B
Transmembrane protease serine 11B

1

3

High-throughput

0.437

High

399705

MARH3
E3 ubiquitin-protein ligase MARCHF3

1

2

High-throughput

0.437

High

399707

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

2

Small-scale

0.437

High

399713

CXD3
Gap junction delta-3 protein

1

1

High-throughput

0.437

High

399721

LPAR1
Lysophosphatidic acid receptor 1

1

10

High-throughput

0.437

High

399744

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

2

High-throughput

0.437

High

399745

ACHA9
Neuronal acetylcholine receptor subunit alpha-9

1

3

High-throughput

0.437

High

104086

F5H1C8
Solute carrier family 15 member 3

1

2

High-throughput

0.407

High

190185

MOT4
Monocarboxylate transporter 4

1

3

High-throughput

0.407

High

351196

MOT3
Monocarboxylate transporter 3

1

3

High-throughput

0.407

High

399661

5HT1E
5-hydroxytryptamine receptor 1E

1

1

High-throughput

0.407

High

399669

EAA4
Excitatory amino acid transporter 4

1

1

High-throughput

0.407

High

399670

CXCR3
C-X-C chemokine receptor type 3

1

6

High-throughput

0.407

High

399677

CXCR4
C-X-C chemokine receptor type 4

1

7

High-throughput

0.407

High

399683

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.407

High

399693

S35F1
Solute carrier family 35 member F1

1

5

High-throughput

0.407

High

399695

MFSD5
Molybdate-anion transporter

1

1

High-throughput

0.407

High

399697

GTR7
Solute carrier family 2, facilitated glucose transporter member 7

1

1

High-throughput

0.407

High

399708

S22A9
Organic anion transporter 7

1

1

High-throughput

0.407

High

399709

S35F2
Solute carrier family 35 member F2

1

3

High-throughput

0.407

High

399716

ZNT7
Zinc transporter 7

1

2

High-throughput

0.407

High

399729

B3A4
Anion exchange protein 4

1

1

High-throughput

0.407

High

399730

CK5P2
CDK5 regulatory subunit-associated protein 2

1

1

High-throughput

0.407

High

399733

S1PR3
Sphingosine 1-phosphate receptor 3

1

10

High-throughput

0.407

High

399736

S22A4
Solute carrier family 22 member 4

1

1

High-throughput

0.407

High

399746

LAT2
Large neutral amino acids transporter small subunit 2

1

1

High-throughput

0.407

High

399756

S4A7
Sodium bicarbonate cotransporter 3

1

1

High-throughput

0.407

High

399740

CD209
CD209 antigen

3

0

High-throughput

0.347

High

399672

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2

2

0

High-throughput

0.328

High

399659

INSRR
Insulin receptor-related protein

1

0

High-throughput

0.279

Low

399694

TM268
Transmembrane protein 268

1

0

High-throughput

0.279

Low

399717

O13J1
Olfactory receptor 13J1

1

0

High-throughput

0.279

Low

399719

CC107
Coiled-coil domain-containing protein 107

1

0

High-throughput

0.279

Low

399724

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.279

Low

399726

DCNL1
DCN1-like protein 1

1

0

High-throughput

0.279

Low

399728

SORC2
VPS10 domain-containing receptor SorCS2 [Cleaved into: SorCS2 122 kDa chain; SorCS2 104 kDa chain; SorCS2 18 kDa chain]

1

0

High-throughput

0.279

Low

399739

NCKX3
Sodium/potassium/calcium exchanger 3

1

0

High-throughput

0.279

Low

399743

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.279

Low

399747

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.279

Low

399749

STA13
StAR-related lipid transfer protein 13

1

0

Small-scale

0.265

Low

330557

KI20A
Kinesin-like protein KIF20A

1

0

High-throughput

0.249

Low

399671

DYN2
Dynamin-2

1

0

High-throughput

0.249

Low

399722

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low

399727

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

230936

TYOBP
TYRO protein tyrosine kinase-binding protein

1

0

High-throughput

0.232

Low

255960

S19A2
Thiamine transporter 1

1

0

High-throughput

0.232

Low

399668

S6A12
Sodium- and chloride-dependent betaine transporter

1

0

High-throughput

0.232

Low

399685

MF13A
Transmembrane protein 180

1

0

High-throughput

0.232

Low

399689

TM241
UDP-N-acetylglucosamine transporter TMEM241

1

0

High-throughput

0.232

Low

399711

S35F3
Solute carrier family 35 member F3

1

0

High-throughput

0.232

Low

399725

S35A4
Probable UDP-sugar transporter protein SLC35A4

1

0

High-throughput

0.232

Low

399735

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

0

Small-scale

0.213

Low


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Last updated: 11Aug2025