HitPredict

Interactor 1: CCL16 (O15467)
C-C motif chemokine 16 (Chemokine CC-4) (HCC-4) (Chemokine LEC) (IL-10-inducible chemokine) (LCC-1) (Liver-expressed chemokine) (Lymphocyte and monocyte chemoattractant) (LMC) (Monotactin-1) (MTN-1) (NCC-4) (Small-inducible cytokine A16)
Gene: CCL16

Interactor 2: CCR1 (P32246)
C-C chemokine receptor type 1 (C-C CKR-1) (CC-CKR-1) (CCR-1) (CCR1) (HM145) (LD78 receptor) (Macrophage inflammatory protein 1-alpha receptor) (MIP-1alpha-R) (RANTES-R) (CD antigen CD191)
Gene: CCR1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	11470772, 10910894
Identification Methods	biochemical, fluorescence technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006935 - chemotaxis GO:0006954 - inflammatory response GO:0007267 - cell-cell signaling GO:0070098 - chemokine-mediated signaling pathway GO:0070374 - positive regulation of ERK1 and ERK2 cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 120 Hs			1 355
+	Hs
		180162 CCL16_HUMAN (1-120): 3.49e-39: 129: 100.00		CCR8_HUMAN (12-337): 2.77e-85: 263: 42.30
+	Hs
		561728 CL3L1_HUMAN (1-95): 2.37e-34: 115: 34.38		CCR1_HUMAN (1-355): 4.53e-90: 276: 100.00
+	Hs
		526560 CCL4_HUMAN (1-94): 7.42e-34: 114: 38.95		CCR1_HUMAN (1-355): 4.53e-90: 276: 100.00
+	Mm
		500591 CCL3_MOUSE (1-95): 9.34e-34: 114: 37.50		CCR3_MOUSE (9-355): 1.75e-86: 266: 64.55
+	Hs
		1305163 CCL13_HUMAN (1-99): 3.28e-35: 118: 31.00		ACKR4_HUMAN (8-343): 5.14e-84: 260: 32.16
+	Mm
		500590 CCL3_MOUSE (1-95): 9.34e-34: 114: 37.50		CCR1_MOUSE (1-355): 1.09e-82: 257: 80.00
+	Hs
		180160 CCL16_HUMAN (1-120): 3.49e-39: 129: 100.00		CCR2_HUMAN (10-326): 3.51e-74: 235: 55.66
+	Hs
		180161 CCL16_HUMAN (1-120): 3.49e-39: 129: 100.00		CCR5_HUMAN (6-355): 1.7e-72: 230: 54.26
+	Hs
		783833 CCL13_HUMAN (1-99): 3.28e-35: 118: 31.00		CCR2_HUMAN (10-326): 3.51e-74: 235: 55.66
+	Hs
		849619 CCL13_HUMAN (1-99): 3.28e-35: 118: 31.00		CCR3_HUMAN (1-355): 4.82e-73: 232: 62.54
+	Hs
		849654 CCL13_HUMAN (1-99): 3.28e-35: 118: 31.00		CCR5_HUMAN (6-355): 1.7e-72: 230: 54.26
+	Hs
		561732 CL3L1_HUMAN (1-95): 2.37e-34: 115: 34.38		CCR3_HUMAN (1-355): 4.82e-73: 232: 62.54
+	Hs
		526564 CCL4_HUMAN (1-94): 7.42e-34: 114: 38.95		CCR3_HUMAN (1-355): 4.82e-73: 232: 62.54
+	Hs
		561733 CL3L1_HUMAN (1-95): 2.37e-34: 115: 34.38		CCR5_HUMAN (6-355): 1.7e-72: 230: 54.26
+	Hs
		526565 CCL4_HUMAN (1-94): 7.42e-34: 114: 38.95		CCR5_HUMAN (6-355): 1.7e-72: 230: 54.26
+	Hs
		134400 CCL13_HUMAN (1-99): 3.28e-35: 118: 31.00		ACKR2_HUMAN (4-324): 3.38e-59: 197: 40.30
+	Hs
		134356 CCL4_HUMAN (1-94): 7.42e-34: 114: 38.95		ACKR2_HUMAN (4-324): 3.38e-59: 197: 40.30
+	Hs
		180159 CCL16_HUMAN (1-120): 3.49e-39: 129: 100.00		CXCR5_HUMAN (31-318): 3.49e-44: 157: 32.20
+	Hs
		830629 CCL13_HUMAN (1-99): 3.28e-35: 118: 31.00		CXCR3_HUMAN (13-318): 1.5e-44: 158: 32.81
+	Hs
		526561 CCL4_HUMAN (1-94): 7.42e-34: 114: 38.95		CXCR5_HUMAN (31-318): 3.49e-44: 157: 32.20