HitPredict

Interactor 1: YKT6 (O15498)
Synaptobrevin homolog YKT6 (EC 2.3.1.-)
Gene: YKT6

Interactor 2: VAMP5 (O95183)
Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin)
Gene: VAMP5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Longin~Synaptobrevin, Synaptobrevin~Synaptobrevin
Common GO terms	GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane GO:0030659 - cytoplasmic vesicle membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 198 Hs			1 116
+	Dm
		1178144 Q9W3M8_DROME (1-196): 9.21e-71: 215: 61.74		Q7JYX5_DROME (4-96): 1.36e-32: 114: 31.18
+	Dm
		577266 Q9W3M8_DROME (1-196): 9.21e-71: 215: 61.74		SYB_DROME (2-88): 9.74e-30: 105: 39.08
+	Hs
		263123 SC22B_HUMAN (1-196): 2.72e-63: 196: 19.60		VAMP5_HUMAN (1-116): 2.4e-35: 118: 100.00
+	Dm
		115809 M9PGI6_DROME (3-195): 3.74e-59: 185: 21.03		Q7JYX5_DROME (4-96): 1.36e-32: 114: 31.18
+	Hs
		306775 VAMP7_HUMAN (28-193): 7.9e-57: 180: 22.03		VAMP5_HUMAN (1-116): 2.4e-35: 118: 100.00
+	Sc
		731090 YKT6_YEAST (1-198): 9.98e-69: 209: 47.00		NYV1_YEAST (9-81): 2.24e-21: 86.9: 21.92
+	Dm
		115796 M9PGI6_DROME (3-195): 3.74e-59: 185: 21.03		SYB_DROME (2-88): 9.74e-30: 105: 39.08
+	Hs
		850543 VAMP7_HUMAN (28-193): 7.9e-57: 180: 22.03		VAMP7_HUMAN (4-96): 5.88e-26: 98: 31.18
+	Dm
		577225 Q7JYX5_DROME (28-194): 7.94e-54: 172: 25.84		SYB_DROME (2-88): 9.74e-30: 105: 39.08
+	Hs
		850567 VAMP7_HUMAN (28-193): 7.9e-57: 180: 22.03		VAMP3_HUMAN (2-72): 2.01e-24: 90.7: 38.03
+	Sc
		605833 SEC22_YEAST (1-192): 2.06e-45: 151: 21.32		SNC2_YEAST (2-74): 6.15e-24: 90: 23.29
+	Sc
		605883 SEC22_YEAST (1-192): 2.06e-45: 151: 21.32		NYV1_YEAST (9-81): 2.24e-21: 86.9: 21.92