HitPredict

Interactor 1: CFLAR (O15519)
CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]
Gene: CFLAR

Interactor 2: UBP8 (P40818)
Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8)
Gene: USP8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.634

Property	Details
Experiments	27321185, 31443721
Identification Methods	affinity chromatography technology, pull down, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006508 - proteolysis GO:0071549 - cellular response to dexamethasone stimulus
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 480 Hs			1 1118
+	Hs
		271091 CASP8_HUMAN (6-478): 8.27e-152: 442: 24.85		UBP2_HUMAN (527-1111): 7.7e-120: 384: 29.62
+	Hs
		64206 CASP8_HUMAN (6-478): 8.27e-152: 442: 24.85		UBP27_HUMAN (744-1109): 3.62e-106: 341: 26.80
+	Hs
		181653 CFLAR_HUMAN (1-480): 5.94e-178: 509: 100.00		UBP15_HUMAN (964-1106): 1.96e-34: 145: 49.65
+	Hs
		877172 CASP6_HUMAN (228-479): 7.99e-83: 259: 22.42		UBP15_HUMAN (964-1106): 1.96e-34: 145: 49.65