HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	29991678, 22973453, 12070153
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005737 - cytoplasm GO:0019901 - protein kinase binding GO:0071230 - cellular response to amino acid stimulus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 1210
+	Mm
		222646 SOCS5_MOUSE (3-210): 4.32e-45: 158: 18.98		EGFR_MOUSE (1-1210): 0: 1258: 90.35
+	Hs
		256842 SOCS5_HUMAN (3-210): 3.81e-46: 161: 19.44		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		338763 SOCS4_HUMAN (3-210): 8.16e-43: 151: 18.98		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		339121 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		181866 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		ERBB4_HUMAN (1-1199): 0: 1137: 49.46
+	Hs
		256853 SOCS5_HUMAN (3-210): 3.81e-46: 161: 19.44		ERBB4_HUMAN (1-1199): 0: 1137: 49.46
+	Hs
		181758 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		256843 SOCS5_HUMAN (3-210): 3.81e-46: 161: 19.44		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		384022 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		256849 SOCS5_HUMAN (3-210): 3.81e-46: 161: 19.44		ERBB3_HUMAN (1-1210): 0: 1080: 40.95
+	Hs
		602023 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		ERBB3_HUMAN (1-1210): 0: 1080: 40.95
+	Hs
		146667 SOCS7_HUMAN (22-209): 5.3e-49: 169: 22.75		INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87
+	Mm
		193338 SOCS1_MOUSE (1-211): 7.14e-52: 167: 93.87		INSR_MOUSE (428-1032): 4.47e-109: 375: 19.65
+	Hs
		181763 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87
+	Hs
		411523 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87
+	Hs
		181850 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68
+	Mm
		193358 SOCS1_MOUSE (1-211): 7.14e-52: 167: 93.87		FAK2_MOUSE (716-974): 4.22e-52: 201: 37.64
+	Hs
		992596 SOCS4_HUMAN (3-210): 8.16e-43: 151: 18.98		ACK1_HUMAN (691-967): 4.54e-56: 214: 39.58
+	Hs
		181772 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47
+	Hs
		435801 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47