Protein: FLII
Protein flightless-1 homolog

Gene: FLII
Organism: Homo sapiens
Interactions: 228
UniProt ID: Q13045

Gene Ontology (top 5):
GO:0002102 - podosome
GO:0003779 - actin binding
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

701975

TMOD1
Tropomodulin-1

5

14

High-throughput

0.919

High

952789

ACTB
Actin, cytoplasmic 1

3

20

High-throughput

0.847

High

1093322

TMOD3
Tropomodulin-3

2

13

High-throughput

0.811

High

1093324

TMOD4
Tropomodulin-4

2

13

High-throughput

0.811

High

786579

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

2

15

High-throughput

0.789

High

993152

ACTG
Actin, cytoplasmic 2

2

20

High-throughput

0.789

High

355204

ACL6A
Actin-like protein 6A

2

19

Small-scale

0.754

High

1093240

LRRF1
Leucine-rich repeat flightless-interacting protein 1

7

2

Small-scale

0.751

High

667817

CDK2
Cyclin-dependent kinase 2

1

2

High-throughput

0.691

High

908248

PRKX
cAMP-dependent protein kinase catalytic subunit PRKX

1

3

High-throughput

0.691

High

916649

PPP5
Serine/threonine-protein phosphatase 5

1

20

High-throughput

0.691

High

920434

DAPK1
Death-associated protein kinase 1

1

11

High-throughput

0.691

High

968279

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

15

High-throughput

0.691

High

1093218

MK07
Mitogen-activated protein kinase 7

1

5

High-throughput

0.691

High

1093297

PI3R4
Phosphoinositide 3-kinase regulatory subunit 4

1

6

High-throughput

0.691

High

995568

ACTC
Actin, alpha cardiac muscle 1

1

18

High-throughput

0.665

High

1093318

ANLN
Anillin

3

5

High-throughput

0.656

High

563703

CFTR
Cystic fibrosis transmembrane conductance regulator

3

5

High-throughput

0.643

High

396016

ESR1
Estrogen receptor

2

20

Small-scale

0.629

High

136085

PLK4
Serine/threonine-protein kinase PLK4

1

5

Small-scale

0.618

High

375470

RASK
GTPase KRas

1

13

High-throughput

0.618

High

400751

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

High-throughput

0.618

High

440053

LCK
Tyrosine-protein kinase Lck

1

7

High-throughput

0.618

High

631197

RAB5A
Ras-related protein Rab-5A

1

6

Small-scale

0.618

High

728204

AKT1
RAC-alpha serine/threonine-protein kinase

1

3

Small-scale

0.618

High

897782

CDK9
Cyclin-dependent kinase 9

1

7

High-throughput

0.618

High

919924

PLK1
Serine/threonine-protein kinase PLK1

1

3

High-throughput

0.618

High

958094

ARP3
Actin-related protein 3

1

20

High-throughput

0.618

High

1093237

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.618

High

1093290

AURKB
Aurora kinase B

1

7

High-throughput

0.618

High

1093342

LRRF2
Leucine-rich repeat flightless-interacting protein 2

3

11

Small-scale

0.607

High

239049

ZNRD2
Protein ZNRD2

2

0

High-throughput

0.602

High

876842

KC1A
Casein kinase I isoform alpha

1

0

High-throughput

0.586

High

241547

PRKN
E3 ubiquitin-protein ligase parkin

2

2

High-throughput

0.584

High

259878

BRD4
Bromodomain-containing protein 4

2

3

High-throughput

0.584

High

345740

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

1

High-throughput

0.584

High

371906

MYC
Myc proto-oncogene protein

2

6

High-throughput

0.584

High

799054

BRCA1
Breast cancer type 1 susceptibility protein

2

3

High-throughput

0.584

High

830652

CCNF
Cyclin-F

2

3

High-throughput

0.584

High

1093226

DX39B
Spliceosome RNA helicase DDX39B

2

3

Small-scale

0.584

High

391241

FRIL
Ferritin light chain

2

0

High-throughput

0.576

High

943927

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

11

High-throughput

0.575

High

967696

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

15

High-throughput

0.575

High

987598

GRB2
Growth factor receptor-bound protein 2

1

11

High-throughput

0.575

High

1093245

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

20

High-throughput

0.575

High

277924

SH3L1
Adapter SH3BGRL

2

2

High-throughput

0.571

High

537074

HSP7C
Heat shock cognate 71 kDa protein

2

4

High-throughput

0.571

High

1093265

CARM1
Histone-arginine methyltransferase CARM1

1

2

Small-scale

0.561

High

1093286

RNF34
E3 ubiquitin-protein ligase RNF34

1

1

Small-scale

0.561

High

411840

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.553

High

1093254

LRC31
Leucine-rich repeat-containing protein 31

1

19

High-throughput

0.553

High

1093311

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

11

High-throughput

0.553

High

1093335

ALK
ALK tyrosine kinase receptor

1

20

Small-scale

0.553

High

788005

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

2

High-throughput

0.541

High

123683

MYO1C
Unconventional myosin-Ic

1

14

High-throughput

0.536

High

228580

STRN
Striatin

1

6

High-throughput

0.536

High

461417

HS90A
Heat shock protein HSP 90-alpha

1

3

Small-scale

0.536

High

618685

ML12A
Myosin regulatory light chain 12A

1

4

High-throughput

0.536

High

637485

FLNA
Filamin-A

1

9

High-throughput

0.536

High

655809

TBG1
Tubulin gamma-1 chain

1

3

High-throughput

0.536

High

772773

MYH9
Myosin-9

1

5

High-throughput

0.536

High

862826

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

3

High-throughput

0.536

High

876582

NEST
Nestin

1

11

High-throughput

0.536

High

964597

DCAF7
DDB1- and CUL4-associated factor 7

1

4

High-throughput

0.536

High

1052003

CALD1
Caldesmon

1

19

High-throughput

0.536

High

1093219

SRSF5
Serine/arginine-rich splicing factor 5

1

1

High-throughput

0.536

High

1093234

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

7

High-throughput

0.536

High

1093235

DREB
Drebrin

1

4

High-throughput

0.536

High

1093238

KIF7
Kinesin-like protein KIF7

1

3

High-throughput

0.536

High

1093243

PDZ11
PDZ domain-containing protein 11

1

4

High-throughput

0.536

High

1093244

HERC4
Probable E3 ubiquitin-protein ligase HERC4

1

4

High-throughput

0.536

High

1093262

CTU1
Cytoplasmic tRNA 2-thiolation protein 1

1

1

High-throughput

0.536

High

1093268

ABRA
Actin-binding Rho-activating protein

1

2

High-throughput

0.536

High

1093274

FBX30
F-box only protein 30

1

3

High-throughput

0.536

High

1093317

MED4
Mediator of RNA polymerase II transcription subunit 4

1

1

High-throughput

0.536

High

1093319

MYO5C
Unconventional myosin-Vc

1

7

High-throughput

0.536

High

1093320

DISC1
Disrupted in schizophrenia 1 protein

1

3

High-throughput

0.536

High

1093329

FBX40
F-box only protein 40

1

3

High-throughput

0.536

High

1093338

SGT1
Protein SGT1 homolog

1

12

High-throughput

0.536

High

1093306

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

8

Small-scale

0.527

High

1093292

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.518

High

846270

MATR3
Matrin-3

1

1

High-throughput

0.515

High

456061

CRGD
Gamma-crystallin D

1

0

High-throughput

0.513

High

822141

PSB10
Proteasome subunit beta type-10

1

0

High-throughput

0.513

High

1093232

TEBP
Prostaglandin E synthase 3

1

0

High-throughput

0.513

High

1093239

CTU2
Cytoplasmic tRNA 2-thiolation protein 2

1

0

High-throughput

0.513

High

1093253

CC174
Coiled-coil domain-containing protein 174

1

0

High-throughput

0.513

High

1093258

CENPQ
Centromere protein Q

1

0

High-throughput

0.513

High

1093260

MYCPP
C-myc promoter-binding protein

1

0

High-throughput

0.513

High

1093261

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.513

High

1093264

JAZF1
Juxtaposed with another zinc finger protein 1

1

0

High-throughput

0.513

High

1093316

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.513

High

1093330

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.513

High

1093233

NCOA2
Nuclear receptor coactivator 2

1

1

Small-scale

0.501

High

1093339

GRIP1
Glutamate receptor-interacting protein 1

1

7

Small-scale

0.501

High

229006

AKAP8
A-kinase anchor protein 8

1

0

High-throughput

0.493

High

1093269

KLH34
Kelch-like protein 34

1

3

High-throughput

0.489

High

1093271

TTC9C
Tetratricopeptide repeat protein 9C

1

4

High-throughput

0.489

High

1093325

CFA97
Cilia- and flagella-associated protein 97

1

1

High-throughput

0.489

High

124324

HAX1
HCLS1-associated protein X-1

1

1

High-throughput

0.479

High

227531

SPOP
Speckle-type POZ protein

1

3

Small-scale

0.479

High

247870

NUPR1
Nuclear protein 1

1

3

High-throughput

0.479

High

248697

PEPL
Periplakin

1

14

High-throughput

0.479

High

315531

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

323353

TRI37
E3 ubiquitin-protein ligase TRIM37

1

11

High-throughput

0.479

High

330922

KI20A
Kinesin-like protein KIF20A

1

13

High-throughput

0.479

High

342850

HERC2
E3 ubiquitin-protein ligase HERC2

1

8

High-throughput

0.479

High

425481

ISG15
Ubiquitin-like protein ISG15

1

5

High-throughput

0.479

High

459569

PROF1
Profilin-1

1

2

High-throughput

0.479

High

519997

ANDR
Androgen receptor

1

16

High-throughput

0.479

High

534997

BIP
Endoplasmic reticulum chaperone BiP

1

6

High-throughput

0.479

High

588580

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

606704

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

629823

BTF3
Transcription factor BTF3

1

3

High-throughput

0.479

High

657550

GCSP
Glycine dehydrogenase

1

1

High-throughput

0.479

High

664724

CCND1
G1/S-specific cyclin-D1

1

4

High-throughput

0.479

High

695336

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

712856

CASP1
Caspase-1

1

3

Small-scale

0.479

High

718807

CCND2
G1/S-specific cyclin-D2

1

4

Small-scale

0.479

High

764712

CTNB1
Catenin beta-1

1

4

High-throughput

0.479

High

768073

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

866661

CAZA2
F-actin-capping protein subunit alpha-2

1

4

High-throughput

0.479

High

867087

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.479

High

872275

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

907404

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

3

High-throughput

0.479

High

964903

WDR5
WD repeat-containing protein 5

1

3

High-throughput

0.479

High

1032295

OTUD4
OTU domain-containing protein 4

1

2

Small-scale

0.479

High

1067250

EP300
Histone acetyltransferase p300

1

3

High-throughput

0.479

High

1093220

TIF1B
Transcription intermediary factor 1-beta

1

3

High-throughput

0.479

High

1093222

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

2

High-throughput

0.479

High

1093224

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

1093225

CUL3
Cullin-3

1

4

High-throughput

0.479

High

1093227

TRI14
Tripartite motif-containing protein 14

1

6

High-throughput

0.479

High

1093228

DCTN1
Dynactin subunit 1

1

6

High-throughput

0.479

High

1093229

TNIP1
TNFAIP3-interacting protein 1

1

12

High-throughput

0.479

High

1093231

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.479

High

1093236

HIF1A
Hypoxia-inducible factor 1-alpha

1

2

High-throughput

0.479

High

1093241

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

5

High-throughput

0.479

High

1093242

BRDT
Bromodomain testis-specific protein

1

6

High-throughput

0.479

High

1093247

OTUD3
OTU domain-containing protein 3

1

2

Small-scale

0.479

High

1093250

A16L1
Autophagy-related protein 16-1

1

8

High-throughput

0.479

High

1093255

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

14

High-throughput

0.479

High

1093256

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.479

High

1093259

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

1093270

SYNPO
Synaptopodin

1

3

High-throughput

0.479

High

1093275

FBX25
F-box only protein 25

1

1

High-throughput

0.479

High

1093276

OTU7A
OTU domain-containing protein 7A

1

6

Small-scale

0.479

High

1093277

DCA11
DDB1- and CUL4-associated factor 11

1

2

High-throughput

0.479

High

1093278

ASB11
Ankyrin repeat and SOCS box protein 11

1

12

High-throughput

0.479

High

1093279

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

1093280

MY18A
Unconventional myosin-XVIIIa

1

10

High-throughput

0.479

High

1093283

ESR2
Estrogen receptor beta

1

18

High-throughput

0.479

High

1093285

FBXW7
F-box/WD repeat-containing protein 7

1

5

High-throughput

0.479

High

1093291

MYO19
Unconventional myosin-XIX

1

11

High-throughput

0.479

High

1093295

CIC
Protein capicua homolog

1

2

High-throughput

0.479

High

1093296

CEP89
Centrosomal protein of 89 kDa

1

15

High-throughput

0.479

High

1093299

MYD88
Myeloid differentiation primary response protein MyD88

1

1

Small-scale

0.479

High

1093300

ANM1
Protein arginine N-methyltransferase 1

1

2

Small-scale

0.479

High

1093302

LZTS2
Leucine zipper putative tumor suppressor 2

1

13

High-throughput

0.479

High

1093303

OVOL2
Transcription factor Ovo-like 2

1

7

Small-scale

0.479

High

1093305

CP250
Centrosome-associated protein CEP250

1

11

High-throughput

0.479

High

1093307

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

4

Small-scale

0.479

High

1093308

RNF38
E3 ubiquitin-protein ligase RNF38

1

2

Small-scale

0.479

High

1093309

CCDC8
Coiled-coil domain-containing protein 8

1

3

High-throughput

0.479

High

1093310

CHM4B
Charged multivesicular body protein 4b

1

6

High-throughput

0.479

High

1093312

PKHA4
Pleckstrin homology domain-containing family A member 4

1

12

High-throughput

0.479

High

1093313

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

1093315

ECT2
Protein ECT2

1

10

High-throughput

0.479

High

1093321

RNF12
E3 ubiquitin-protein ligase RLIM

1

2

High-throughput

0.479

High

1093323

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

1093327

HDAC6
Protein deacetylase HDAC6

1

5

High-throughput

0.479

High

1093328

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1093331

ANC2
Anaphase-promoting complex subunit 2

1

5

High-throughput

0.479

High

1093332

FBW1B
F-box/WD repeat-containing protein 11

1

5

High-throughput

0.479

High

1093334

MYO5B
Unconventional myosin-Vb

1

7

High-throughput

0.479

High

1093340

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.479

High

1093341

LOXL2
Lysyl oxidase homolog 2

1

3

High-throughput

0.479

High

184288

NPHP1
Nephrocystin-1

1

0

High-throughput

0.458

High

191326

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

0

High-throughput

0.458

High

279352

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

337588

FMNL1
Formin-like protein 1

1

0

Small-scale

0.458

High

482461

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.458

High

621635

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

807396

IF4A3
Eukaryotic initiation factor 4A-III

1

0

High-throughput

0.458

High

941149

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.458

High

1026349

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

1054694

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.458

High

1093223

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

0

High-throughput

0.458

High

1093230

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1093248

PI3R6
Phosphoinositide 3-kinase regulatory subunit 6

1

0

High-throughput

0.458

High

1093263

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

1093266

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.458

High

1093267

ASXL1
Polycomb group protein ASXL1

1

0

High-throughput

0.458

High

1093273

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

1093281

RUBIC
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein

1

0

Small-scale

0.458

High

1093282

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.458

High

1093284

TF3B
Transcription factor IIIB 90 kDa subunit

1

0

Small-scale

0.458

High

1093288

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

1093293

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1093294

F193B
Protein FAM193B

1

0

High-throughput

0.458

High

1093301

PAIP2
Polyadenylate-binding protein-interacting protein 2

1

0

High-throughput

0.458

High

1093314

TDRD3
Tudor domain-containing protein 3

1

0

High-throughput

0.458

High

1093326

SYLC
Leucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

1093337

CRYL1
Lambda-crystallin homolog

1

0

High-throughput

0.458

High

58810

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

1

High-throughput

0.445

High

254998

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

3

High-throughput

0.445

High

429808

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

529722

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.445

High

934543

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.445

High

942589

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

3

High-throughput

0.445

High

1093221

CTBP1
C-terminal-binding protein 1

1

3

High-throughput

0.445

High

1093252

PKHA7
Pleckstrin homology domain-containing family A member 7

1

10

High-throughput

0.445

High

1093298

ZBT18
Zinc finger and BTB domain-containing protein 18

1

9

High-throughput

0.445

High

105846

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

378076

TNFA
Tumor necrosis factor

1

1

High-throughput

0.437

High

1093249

NXNL2
Nucleoredoxin-like protein 2

1

2

Small-scale

0.437

High

1093251

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.437

High

1093272

OTU6B
Deubiquitinase OTUD6B

1

2

Small-scale

0.437

High

1093289

NXNL1
Nucleoredoxin-like protein 1

1

2

Small-scale

0.437

High

1093333

HECD1
E3 ubiquitin-protein ligase HECTD1

1

2

High-throughput

0.437

High

344180

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.426

High

1093246

CE170
Centrosomal protein of 170 kDa

1

0

High-throughput

0.426

High

1093336

ITM2B
Integral membrane protein 2B

1

3

High-throughput

0.407

High

1093304

NAT9
Alpha/beta-tubulin-N-acetyltransferase 9

2

0

High-throughput

0.328

High

1093257

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

1

0

High-throughput

0.279

Low

418096

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

1093287

VP33A
Vacuolar protein sorting-associated protein 33A

1

0

High-throughput

0.249

Low

906268

GPC3
Glypican-3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025