HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	29991678, 11342531
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005159 - insulin-like growth factor receptor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 1382
+	Hs
		146667 SOCS7_HUMAN (22-209): 5.3e-49: 169: 22.75		INSR_HUMAN (1-1382): 0: 1530: 100.00
+	Mm
		193338 SOCS1_MOUSE (1-211): 7.14e-52: 167: 93.87		INSR_MOUSE (1-1382): 0: 1509: 94.36
+	Hs
		411523 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		INSR_HUMAN (1-1382): 0: 1530: 100.00
+	Hs
		147471 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		INSR_HUMAN (1-1382): 0: 1530: 100.00
+	Hs
		181772 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		IGF1R_HUMAN (31-1380): 0: 1353: 56.11
+	Hs
		435801 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		IGF1R_HUMAN (31-1380): 0: 1353: 56.11
+	Hs
		445884 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		ROS1_HUMAN (511-1377): 3.38e-158: 530: 22.63
+	Hs
		181758 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67
+	Hs
		256843 SOCS5_HUMAN (3-210): 3.81e-46: 161: 19.44		ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67
+	Hs
		384022 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67
+	Hs
		147470 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67
+	Hs
		181899 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		ALK_HUMAN (982-1339): 1.96e-70: 263: 40.53
+	Hs
		256861 SOCS5_HUMAN (3-210): 3.81e-46: 161: 19.44		ALK_HUMAN (982-1339): 1.96e-70: 263: 40.53
+	Hs
		1356638 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		ALK_HUMAN (982-1339): 1.96e-70: 263: 40.53
+	Dm
		526800 Q8INY1_DROME (26-210): 6.61e-43: 154: 23.00		7LESS_DROME (1017-1290): 6.19e-65: 246: 45.23
+	Hs
		181796 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		FGFR3_HUMAN (1015-1287): 2.21e-62: 231: 40.78
+	Hs
		181803 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		UFO_HUMAN (789-1294): 1.77e-61: 229: 31.09
+	Hs
		256849 SOCS5_HUMAN (3-210): 3.81e-46: 161: 19.44		ERBB3_HUMAN (33-369): 1.76e-27: 123: 20.11
+	Hs
		602023 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		ERBB3_HUMAN (33-369): 1.76e-27: 123: 20.11
+	Mm
		222646 SOCS5_MOUSE (3-210): 4.32e-45: 158: 18.98		EGFR_MOUSE (337-537): 1.12e-16: 88.2: 20.17