Protein: MERTK
Tyrosine-protein kinase Mer (EC 2.7.10.1) (Proto-oncogene c-Mer) (Receptor tyrosine kinase MerTK)

Gene: MERTK
Organism: Homo sapiens
Interactions: 120
UniProt ID: Q12866

Gene Ontology (top 5):
GO:0001750 - photoreceptor outer segment
GO:0001779 - natural killer cell differentiation
GO:0001818 - negative regulation of cytokine production
GO:0004714 - transmembrane receptor protein tyrosine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1088179

MERTK
Tyrosine-protein kinase Mer

2

20

Small-scale

0.799

High

1088181

GAS6
Growth arrest-specific protein 6

2

20

Small-scale

0.768

High

720205

UFO
Tyrosine-protein kinase receptor UFO

2

19

Small-scale

0.767

High

410801

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.713

High

249127

DSCAM
Cell adhesion molecule DSCAM

1

14

High-throughput

0.698

High

1088185

CDC37
Hsp90 co-chaperone Cdc37

1

20

High-throughput

0.691

High

584528

VAV
Proto-oncogene vav

1

20

Small-scale

0.653

High

424186

S10A8
Protein S100-A8

1

5

High-throughput

0.646

High

461412

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

1060770

ACK1
Activated CDC42 kinase 1

1

19

Small-scale

0.618

High

468312

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

690954

1433T
14-3-3 protein theta

1

20

High-throughput

0.618

High

729787

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.618

High

895544

SERPH
Serpin H1

1

8

High-throughput

0.618

High

971456

1433E
14-3-3 protein epsilon

1

5

High-throughput

0.618

High

1088200

ARHG2
Rho guanine nucleotide exchange factor 2

1

20

High-throughput

0.618

High

1088221

RASF1
Ras association domain-containing protein 1

1

13

High-throughput

0.618

High

1088235

FBW1A
F-box/WD repeat-containing protein 1A

1

3

High-throughput

0.618

High

987593

GRB2
Growth factor receptor-bound protein 2

1

20

Small-scale

0.590

High

1088242

NEMO
NF-kappa-B essential modulator

1

15

High-throughput

0.561

High

964250

SUMO2
Small ubiquitin-related modifier 2

1

1

High-throughput

0.553

High

1088208

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

6

High-throughput

0.553

High

1088210

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

6

High-throughput

0.553

High

1088230

FBW1B
F-box/WD repeat-containing protein 11

1

3

High-throughput

0.553

High

390028

ALBU
Albumin

1

2

High-throughput

0.536

High

480775

LEG1
Galectin-1

1

5

High-throughput

0.536

High

697863

CALR
Calreticulin

1

20

High-throughput

0.536

High

717294

PEBP1
Phosphatidylethanolamine-binding protein 1

1

5

High-throughput

0.536

High

1088229

FBX2
F-box only protein 2

1

14

High-throughput

0.536

High

1088241

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

3

High-throughput

0.536

High

1088206

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

20

High-throughput

0.501

High

228477

LANC1
Glutathione S-transferase LANCL1

1

3

High-throughput

0.500

High

285647

BAF
Barrier-to-autointegration factor

1

9

High-throughput

0.500

High

999632

HBA
Hemoglobin subunit alpha

1

5

High-throughput

0.500

High

1088191

YTHD3
YTH domain-containing family protein 3

1

14

High-throughput

0.500

High

1088213

YTHD1
YTH domain-containing family protein 1

1

9

High-throughput

0.500

High

1088238

YTHD2
YTH domain-containing family protein 2

1

15

High-throughput

0.500

High

446412

G6PI
Glucose-6-phosphate isomerase

1

3

High-throughput

0.489

High

909548

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

5

High-throughput

0.489

High

1065159

SSRP1
FACT complex subunit SSRP1

1

4

High-throughput

0.489

High

1088239

SP16H
FACT complex subunit SPT16

1

1

High-throughput

0.489

High

221572

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

5

High-throughput

0.479

High

339485

ACSL3
Fatty acid CoA ligase Acsl3

1

6

High-throughput

0.479

High

488465

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

6

High-throughput

0.479

High

566653

PDIA4
Protein disulfide-isomerase A4

1

20

High-throughput

0.479

High

832024

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

2

High-throughput

0.479

High

849452

NAMPT
Nicotinamide phosphoribosyltransferase

1

3

High-throughput

0.479

High

894536

GDIB
Rab GDP dissociation inhibitor beta

1

1

High-throughput

0.479

High

894712

EMD
Emerin

1

13

High-throughput

0.479

High

945783

EPIPL
Epiplakin

1

14

High-throughput

0.479

High

957718

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

8

High-throughput

0.479

High

976998

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

5

High-throughput

0.479

High

1008114

PRKDC
DNA-dependent protein kinase catalytic subunit

1

18

High-throughput

0.479

High

1048305

LGUL
Lactoylglutathione lyase

1

1

High-throughput

0.479

High

1066113

NSUN2
RNA cytosine C(5)-methyltransferase NSUN2

1

10

High-throughput

0.479

High

1088182

SYK
Lysine--tRNA ligase

1

7

High-throughput

0.479

High

1088192

RASF3
Ras association domain-containing protein 3

1

4

High-throughput

0.479

High

1088196

IPO4
Importin-4

1

8

High-throughput

0.479

High

1088198

DNJC9
DnaJ homolog subfamily C member 9

1

20

High-throughput

0.479

High

1088201

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

9

High-throughput

0.479

High

1088202

DDX27
Probable ATP-dependent RNA helicase DDX27

1

13

High-throughput

0.479

High

1088205

RBM14
RNA-binding protein 14

1

12

High-throughput

0.479

High

1088209

PARK7
Parkinson disease protein 7

1

2

High-throughput

0.479

High

1088211

NTPCR
Cancer-related nucleoside-triphosphatase

1

11

High-throughput

0.479

High

1088212

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

7

High-throughput

0.479

High

1088214

NAT10
RNA cytidine acetyltransferase

1

2

High-throughput

0.479

High

1088215

SAV1
Protein salvador homolog 1

1

20

High-throughput

0.479

High

1088223

MDN1
Midasin

1

19

High-throughput

0.479

High

1088224

DD19A
ATP-dependent RNA helicase DDX19A

1

5

High-throughput

0.479

High

1088227

BAZ1B
Tyrosine-protein kinase BAZ1B

1

10

High-throughput

0.479

High

1088228

STML2
Stomatin-like protein 2, mitochondrial

1

7

High-throughput

0.479

High

1088231

MRT4
mRNA turnover protein 4 homolog

1

7

High-throughput

0.479

High

1088234

SMC3
Structural maintenance of chromosomes protein 3

1

14

High-throughput

0.479

High

1088237

HYOU1
Hypoxia up-regulated protein 1

1

20

High-throughput

0.479

High

1088240

SRPRB
Signal recognition particle receptor subunit beta

1

20

High-throughput

0.479

High

459883

APT
Adenine phosphoribosyltransferase

1

0

High-throughput

0.458

High

542486

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.458

High

555384

SKI
Ski oncogene

1

0

Small-scale

0.458

High

834300

GARS
Glycine--tRNA ligase

1

0

High-throughput

0.458

High

380750

HBD
Hemoglobin subunit delta

1

5

High-throughput

0.457

High

1088180

TRA2A
Transformer-2 protein homolog alpha

1

5

High-throughput

0.457

High

1088184

SAFB1
Scaffold attachment factor B1

1

14

High-throughput

0.457

High

1088190

NIPA1
Magnesium transporter NIPA1

1

4

High-throughput

0.445

High

1088197

CTL1
Choline transporter-like protein 1

1

2

High-throughput

0.445

High

137709

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

8

High-throughput

0.437

High

255618

DPM1
Dolichol-phosphate mannosyltransferase subunit 1

1

5

High-throughput

0.437

High

277665

H2AY
Core histone macro-H2A.1

1

7

High-throughput

0.437

High

291311

NU155
Nuclear pore complex protein Nup155

1

7

High-throughput

0.437

High

336944

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

2

High-throughput

0.437

High

426260

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

7

High-throughput

0.437

High

469070

SRPRA
Signal recognition particle receptor subunit alpha

1

9

High-throughput

0.437

High

487244

PARP1
Poly [ADP-ribose] polymerase 1

1

12

High-throughput

0.437

High

615375

SON
Protein SON

1

14

High-throughput

0.437

High

853239

CBX5
Chromobox protein homolog 5

1

2

High-throughput

0.437

High

906396

DHB4
Peroxisomal multifunctional enzyme type 2

1

3

High-throughput

0.437

High

1011070

RT22
Small ribosomal subunit protein mS22

1

2

High-throughput

0.437

High

1088183

RRS1
Ribosome biogenesis regulatory protein homolog

1

2

High-throughput

0.437

High

1088186

MIC60
MICOS complex subunit MIC60

1

1

High-throughput

0.437

High

1088187

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

9

High-throughput

0.437

High

1088188

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

7

High-throughput

0.437

High

1088189

ZN326
DBIRD complex subunit ZNF326

1

6

High-throughput

0.437

High

1088193

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

15

High-throughput

0.437

High

1088194

NUP93
Nuclear pore complex protein Nup93

1

5

High-throughput

0.437

High

1088195

KRI1
Protein KRI1 homolog

1

12

High-throughput

0.437

High

1088199

NU205
Nuclear pore complex protein Nup205

1

7

High-throughput

0.437

High

1088207

RBM15
RNA-binding protein 15

1

7

High-throughput

0.437

High

1088216

CCD86
Coiled-coil domain-containing protein 86

1

2

High-throughput

0.437

High

1088217

RPF2
Ribosome production factor 2 homolog

1

1

High-throughput

0.437

High

1088218

SFXN1
Sideroflexin-1

1

1

High-throughput

0.437

High

1088219

ZFP14
Zinc finger protein 14 homolog

1

4

High-throughput

0.437

High

1088220

SSF1
Suppressor of SWI4 1 homolog

1

1

High-throughput

0.437

High

1088225

RBM28
RNA-binding protein 28

1

9

High-throughput

0.437

High

1088226

H2AW
Core histone macro-H2A.2

1

6

High-throughput

0.437

High

1088232

RALY
RNA-binding protein Raly

1

2

High-throughput

0.437

High

1088233

RL26L
Ribosomal protein uL24-like

1

2

High-throughput

0.437

High

1088236

CHTOP
Chromatin target of PRMT1 protein

1

5

High-throughput

0.437

High

1088204

MF14A
Hippocampus abundant transcript 1 protein

1

13

High-throughput

0.407

High

1088203

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.282

High

1088222

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025